World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
21263
World Ranking
6564
National Ranking
468

Overview

Norbert Gretz is affiliated with Heidelberg University in Germany and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work includes a strong focus on molecular biology and cancer research, with a particular emphasis on hepatocarcinogenesis and cell signaling pathways related to liver cancer.

The scientist's publication record demonstrates active engagement with leading journals and research venues. Frequent publication venues include:

  • Frontiers in Immunology
  • Biomedicines
  • Oncogene
  • Frontiers in Physiology
  • International Journal of Molecular Sciences

Norbert Gretz's main research fields comprise biochemistry, genetics and molecular biology, alongside medicine. Their subfields cover molecular biology, cancer research, surgery, biomedical engineering, and cell biology.

The scientist's work encompasses key topics related to cellular signaling and disease mechanisms, such as:

  • Hippo pathway signaling and YAP/TAZ
  • Mesenchymal stem cell research
  • Fibroblast growth factor research
  • Chronic kidney disease and diabetes
  • Laser applications in dentistry and medicine
  • Angiogenesis and VEGF in cancer
  • Photoacoustic and ultrasonic imaging

Several recent papers illustrate their research interests and contributions to the understanding of liver cancer and related cellular processes.

  • Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance, 2020, EBioMedicine
  • TAZ target gene ITGAV regulates invasion and feeds back positively on YAP and TAZ in liver cancer cells, 2020, Cancer Letters
  • YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF/c-MET Signaling in Liver Tumorigenesis, 2020, Cancer Research
  • NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis, 2020, Oncogene
  • Endothelial cells drive organ fibrosis in mice by inducing expression of the transcription factor SOX9, 2024, Science Translational Medicine

The scientist has collaborated frequently with colleagues including Carsten Sticht, Carolina De La Torre, Tiziana Picascia, Carolin Mogler, and Peter Schirmacher, reflecting interdisciplinary engagement in their research projects.

Best Publications

  • Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis

    Heike Olbrich;Manfred Fliegauf;Julia Hoefele;Andreas Kispert

  • Loss of Nephrocystin-3 Function Can Cause Embryonic Lethality, Meckel-Gruber-like Syndrome, Situs Inversus, and Renal-Hepatic-Pancreatic Dysplasia

    Carsten Bergmann;Manfred Fliegauf;Nadina Ortiz Brüchle;Valeska Frank

  • Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma.

    Darjus Felix Tschaharganeh;Xin Chen;Philipp Latzko;Mona Malz

  • Angiotensin II Type 1 Receptor Overexpression in Podocytes Induces Glomerulosclerosis in Transgenic Rats

    Sigrid Hoffmann;Dirk Podlich;Brunhilde Hähnel;Wilhelm Kriz

  • The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis

    Kristin Moreth;Rebekka Brodbeck;Andrea Babelova;Norbert Gretz

  • Reduced capillary density in the myocardium of uremic rats--a stereological study.

    Kerstin Amann;Kerstin Amann;Gabriele Wiest;Gabriele Wiest;Gisela Zimmer;Gisela Zimmer;Norbert Gretz;Norbert Gretz

  • The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton.

    Anna Rachel Gallagher;Anna Cedzich;Norbert Gretz;Stefan Somlo

  • Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth

    Richard Jennemann;Roger Sandhoff;Shijun Wang;Eva Kiss

  • From segmental glomerulosclerosis to total nephron degeneration and interstitial fibrosis: a histopathological study in rat models and human glomerulopathies.

    Wilhelm Kriz;Hiltraud Hosser;Brunhilde Hähnel;Norbert Gretz

  • L-carnosine, a substrate of carnosinase-1, influences glucose metabolism

    Sibylle Sauerhöfer;Gang Yuan;Gerald Stefan Braun;Martina Deinzer

  • Characterization of the Han:SPRD rat model for hereditary polycystic kidney disease

    Katrin Schäfer;Katrin Schäfer;Katrin Schäfer;Norbert Gretz;Norbert Gretz;Norbert Gretz;Michael Bader;Michael Bader;Michael Bader;Ilse Oberbäumer;Ilse Oberbäumer;Ilse Oberbäumer

  • Gene expression profiling of CD34+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis

    C Zheng;L Li;M Haak;B Brors

  • Group testing for pathway analysis improves comparability of different microarray datasets

    Theodora Manoli;Norbert Gretz;Hermann-Josef Gröne;Marc Kenzelmann

  • Telomere Shortening Reduces Regenerative Capacity after Acute Kidney Injury

    Jens H. Westhoff;Carolin Schildhorn;Christoph Jacobi;Meike Hömme

  • Impairment of Sodium Balance in Mice Deficient in Renal Principal Cell Mineralocorticoid Receptor

    Caroline Ronzaud;Johannes Loffing;Markus Bleich;Norbert Gretz

  • Is gender a determinant for evolution of renal failure? A study in autosomal dominant polycystic kidney disease.

    Norbert Gretz;Martin Zeier;Steffen Geberth;Manfred Strauch

  • Gene expression signature of primary imatinib-resistant chronic myeloid leukemia patients

    O Frank;B Brors;A Fabarius;L Li

  • Transcutaneous assessment of renal function in conscious rats with a device for measuring FITC-sinistrin disappearance curves.

    Daniel Schock-Kusch;Qing Xie;Yury Shulhevich;Juergen Hesser

  • Identification of metastasis-associated genes in prostate cancer by genetic profiling of human prostate cancer cell lines.

    Lutz Trojan;Axel Schaaf;Annette Steidler;Markus Haak

  • Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range

    Julie Bachmann;Andreas Raue;Marcel Schilling;Martin E Böhm

Frequent Co-Authors

Peter Schirmacher
Peter Schirmacher University Hospital Heidelberg
Hermann Josef Gröne
Hermann Josef Gröne German Cancer Research Center
Wilhelm Kriz
Wilhelm Kriz Heidelberg University
Stephan Herzig
Stephan Herzig Technical University of Munich
Benedikt Brors
Benedikt Brors German Cancer Research Center
Annemarie Pucci
Annemarie Pucci Heidelberg University
Ursula Klingmüller
Ursula Klingmüller German Cancer Research Center
Hanno Glimm
Hanno Glimm TU Dresden
Gudrun A. Rappold
Gudrun A. Rappold Heidelberg University
Peter P. Nawroth
Peter P. Nawroth Heidelberg University

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