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Patrick W.K. Lee

Patrick W.K. Lee

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
13401
World Ranking
10828
National Ranking
373

Overview

Patrick W.K. Lee is affiliated with the University of Calgary in Canada. Their research spans multiple scientific domains with a primary focus on immunology, microbiology, medicine, biochemistry, genetics, and molecular biology. The work particularly delves into immunology, infectious diseases, and molecular biology as core subfields.

The scientist's scholarly output includes research exploring interferon and immune responses, viral infections and vectors, and inflammasome and immune disorders. These topics highlight a concentration on immune system mechanisms and viral pathogenesis.

Among the recent contributions, one publication stands out:

  • Editor's Note: Oncogenic Ras Promotes Reovirus Spread by Suppressing IFNβ Production through Negative Regulation of RIG-I Signaling, 2022, published in Cancer Research

This work reflects the intersection between virology and immune signaling pathways. It was authored alongside frequent collaborators including Maya Shmulevitz, Lu-Zhe Pan, Katy Garant, and Da Pan.

Cancer Research features as the main publication venue for their documented work, indicating a presence within biomedical research circles concerned with cancer and related molecular biology.

Patrick W.K. Lee's profile suggests an active engagement with topics connecting molecular signaling and viral immunology, contributing to the understanding of immune evasion and pathogen spread.

Best Publications

  • Reovirus Therapy of Tumors with Activated Ras Pathway

    Matthew C. Coffey;James E. Strong;Peter A. Forsyth;Patrick W. K. Lee

  • The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus

    James E. Strong;Matthew C. Coffey;Damu Tang;Pauline Sabinin

  • Protein σ1 is the reovirus cell attachment protein

    Patrick W.K. Lee;Edward C. Hayes;Wolfgang K. Joklik

  • DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

    Richard A. Woo;Kevin G. McLure;Susan P. Lees-Miller;Derrick E. Rancourt

  • How p53 binds DNA as a tetramer.

    Kevin G. McLure;Patrick W.K. Lee

  • Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1

    Faris Farassati;An-Dao Yang;Patrick W. K. Lee

  • Reovirus oncolysis: The Ras/RalGEF/p38 pathway dictates host cell permissiveness to reovirus infection

    Kara L. Norman;Kensuke Hirasawa;An-Dao Yang;Michael A. Shields

  • Oncolytic Reovirus against Ovarian and Colon Cancer

    Kensuke Hirasawa;Sandra G Nishikawa;Kara L Norman;Tommy Alain

  • Reovirus Oncolysis of Human Breast Cancer

    Kara L. Norman;Matthew C. Coffey;Kensuke Hirasawa;Douglas J. Demetrick

  • Systemic Reovirus Therapy of Metastatic Cancer in Immune-competent Mice

    Kensuke Hirasawa;Sandra G. Nishikawa;Kara L. Norman;Matthew C. Coffey

  • Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response

    Melissa T. Jack;Richard A. Woo;Atsushi Hirao;Alison Cheung

  • Evidence That the Epidermal Growth Factor Receptor on Host Cells Confers Reovirus Infection Efficiency

    James E. Strong;Damu Tang;Patrick W.K. Lee

  • Oil sands operations as a large source of secondary organic aerosols

    John Liggio;Shao-Meng Li;Katherine Hayden;Youssef M. Taha

  • Reovirus as a novel oncolytic agent

    Kara L. Norman;Patrick W.K. Lee

  • The α-anomeric form of sialic acid is the minimal receptor determinant recognized by reovirus

    Ralph W. Paul;Anthony H.C. Choi;Patrick W.K. Lee

  • Antitumor Benefits of Antiviral Immunity: An Underappreciated Aspect of Oncolytic Virotherapies

    Shashi Gujar;Jonathan G. Pol;Youra Kim;Patrick W. Lee

  • Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells

    Jane L. Watson;Richard Hill;Paul B. Yaffe;Anna Greenshields

  • Biogenesis of p53 Involves Cotranslational Dimerization of Monomers and Posttranslational Dimerization of Dimers IMPLICATIONS ON THE DOMINANT NEGATIVE EFFECT

    Chris D. Nicholls;Kevin G. McLure;Michael A. Shields;Patrick W.K. Lee

  • Human mast cell activation with virus-associated stimuli leads to the selective chemotaxis of natural killer cells by a CXCL8-dependent mechanism.

    Sarah M Burke;Thomas B Issekutz;Karkada Mohan;Patrick W K Lee

  • DNA damage‐induced apoptosis requires the DNA‐dependent protein kinase, and is mediated by the latent population of p53

    Richard A. Woo;Melissa T. Jack;Yang Xu;Sandeep Burma

Frequent Co-Authors

Matthew C. Coffey
Matthew C. Coffey Oncolytics Biotech (Canada)
Gustavo Leone
Gustavo Leone Medical University of South Carolina
Michael D. Petraglia
Michael D. Petraglia Griffith University
Anna Janowska-Wieczorek
Anna Janowska-Wieczorek University of Alberta
Stephen M. Hubbard
Stephen M. Hubbard University of Calgary
Damu Tang
Damu Tang McMaster University
Alfredo Pérez-González
Alfredo Pérez-González Complutense University of Madrid
David M. Waisman
David M. Waisman Dalhousie University
Manuel Domínguez-Rodrigo
Manuel Domínguez-Rodrigo University of Alcalá
Wolfgang K. Joklik
Wolfgang K. Joklik Duke University

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