World's Best Scientists 2026 revealed!
Jacqueline A. Lees

Jacqueline A. Lees

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
22838
World Ranking
7660
National Ranking
3491

Overview

Jacqueline A. Lees is affiliated with MIT in the United States and has extensively contributed to the field of Biochemistry, Genetics, and Molecular Biology. Their research output mainly focuses on Molecular Biology, Genetics, Oncology, Cell Biology, and Hematology.

The scientist's work covers several main topics including:

  • Epigenetics and DNA Methylation
  • Genetic and Kidney Cyst Diseases
  • Pluripotent Stem Cells Research
  • Cancer Cells and Metastasis
  • Hedgehog Signaling Pathway Studies
  • Cancer-related gene regulation
  • Hematopoietic Stem Cell Transplantation

Jacqueline A. Lees has frequently published in a variety of scientific journals. The most frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Science Advances
  • Pigment Cell & Melanoma Research
  • SSRN Electronic Journal

Co-authorship is a significant aspect of their scientific work, collaborating often with researchers such as:

  • Robert A. Weinberg
  • Vincent J. Guen
  • Molly M. Wilson
  • Matthieu Le Gallo
  • Florence Godey

Recent papers demonstrate the breadth of Jacqueline A. Lees's research interests and collaborations. Key recent publications are:

  • "Emerging Mechanisms by which EMT Programs Control Stemness" (2020), published in Trends in Cancer
  • "Cell size is a determinant of stem cell potential during aging" (2021), published in Science Advances
  • "Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis" (2022), published in Nature Cell Biology
  • "An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis" (2021), published in Science Advances
  • "Targeting the cyclin-dependent kinase 5 in metastatic melanoma" (2020), published in Proceedings of the National Academy of Sciences

Best Publications

  • Sibling rivalry in the E2F family.

    Jeffrey M Trimarchi;Jacqueline A Lees

  • Altered PTEN Expression as a Diagnostic Marker for the Earliest Endometrial Precancers

    George L. Mutter;Ming Chieh Lin;Jeffrey T. Fitzgerald;Jennifer B. Kum

  • Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors

    P.S. Danielian;R. White;J.A. Lees;M.G. Parker

  • A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

    Kristian Helin;Jacqueline A. Lees;Marc Vidal;Nicholas Dyson

  • Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor

    Stephen E. Fawell;Jacqueline A. Lees;Roger White;Malcolm G. Parker

  • p53-Deficient Cells Rely on ATM- and ATR-Mediated Checkpoint Signaling through the p38MAPK/MK2 Pathway for Survival after DNA Damage

    H. Christian Reinhardt;Aaron S. Aslanian;Jacqueline A. Lees;Michael B. Yaffe

  • The retinoblastoma protein binds to a family of E2F transcription factors.

    J A Lees;M Saito;M Vidal;M Valentine

  • Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.

    K. Helin;Chin-Lee Wu;A. R. Fattaey;J. A. Lees

  • Differential regulation of E2F transactivation by cyclin/cdk2 complexes.

    B D Dynlacht;O Flores;J A Lees;E Harlow

  • Immunohistochemical Evidence of Loss of PTEN Expression in Primary Ductal Adenocarcinomas of the Breast

    Aurel Perren;Liang Ping Weng;Alexander H. Boag;Ulricke Ziebold

  • Many Ribosomal Protein Genes Are Cancer Genes in Zebrafish

    Adam Amsterdam;Kirsten C Sadler;Kevin Lai;Sarah Farrington

  • E2F-4 Switches from p130 to p107 and pRB in Response to Cell Cycle Reentry

    K Moberg;M A Starz;J A Lees

  • STRUCTURAL ORGANIZATION AND EXPRESSION OF THE MOUSE ESTROGEN-RECEPTOR

    R. White;J. A. Lees;M. Needham;J. Ham

  • E2f3 is critical for normal cellular proliferation.

    Patrick O. Humbert;Raluca Verona;Jeffrey M. Trimarchi;Catherine Rogers

  • Differential Nuclear and Cytoplasmic Expression of PTEN in Normal Thyroid Tissue, and Benign and Malignant Epithelial Thyroid Tumors

    Oliver Gimm;Aurel Perren;Aurel Perren;Liang-Ping Weng;Debbie J. Marsh;Debbie J. Marsh

  • The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.

    J.A. Lees;K.J. Buchkovich;D.R. Marshak;C.W. Anderson

  • Life and death decisions by the E2F transcription factors

    Phillip J Iaquinta;Jacqueline A Lees

  • Identification of two transactivation domains in the mouse oestrogen receptor.

    Jacqueline A. Lees;Stephen E. Fawell;Malcolm G. Parker

  • Single-molecule transcript counting of stem-cell markers in the mouse intestine

    Shalev Itzkovitz;Anna Lyubimova;Anna Lyubimova;Irene C. Blat;Mindy Maynard

  • PTEN Suppresses Breast Cancer Cell Growth by Phosphatase Activity-dependent G1 Arrest followed by Cell Death

    Liang Ping Weng;Wendy M. Smith;Patricia L M Dahia;Ulrike Ziebold

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Jacqueline A. Lees

Trending Scientists