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Biology and Biochemistry

D-Index
61
Citations
19607
World Ranking
11139
National Ranking
103

Overview

Rami I. Aqeilan is a researcher affiliated with the Hebrew University of Jerusalem in Israel, with a primary focus on Biochemistry, Genetics, and Molecular Biology. Their work spans across 72 publications in this broad field, with a strong emphasis on molecular biology and genetics as subfields, as well as contributions in cellular and molecular neuroscience, oncology, and cancer research.

Their research covers a diverse range of topics, notably genetics and neurodevelopmental disorders, DNA repair mechanisms, CRISPR and genetic engineering, nuclear receptors and signaling, ubiquitin and proteasome pathways, renal and related cancers, and RNA modifications related to cancer.

Rami I. Aqeilan has published frequently in prominent venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Death and Disease
  • Cells
  • Cell Death and Differentiation
  • EMBO Molecular Medicine

Their recent scientific contributions include notable papers such as:

  • "Apoptotic cell death in disease-Current understanding of the NCCD 2023" (2023, Cell Death and Differentiation)
  • "AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer" (2022, Cancer Discovery)
  • "Twist1-induced miR-199a-3p promotes liver fibrosis by suppressing caveolin-2 and activating TGF-β pathway" (2020, Signal Transduction and Targeted Therapy)
  • "Modeling genetic epileptic encephalopathies using brain organoids" (2021, EMBO Molecular Medicine)
  • "Pleiotropic tumor suppressor functions of WWOX antagonize metastasis" (2020, Signal Transduction and Targeted Therapy)

This body of work demonstrates involvement in understanding mechanisms of apoptosis, cancer resistance, fibrotic processes, genetic modeling of neurological diseases, and tumor suppression pathways.

Collaboration forms a significant aspect of their research activity. Frequent co-authors include:

  • Osama Hidmi
  • Sara Oster
  • Srinivasarao Repudi
  • Daniel Steinberg
  • Jonathan Monin

Through these collaborations and a multidisciplinary approach, the scientist's research contributes to understanding complex molecular processes related to genetics, cancer biology, and neurodevelopmental disorders. This integrated approach helps address areas linking genetics with disease pathologies and therapeutic strategies.

Best Publications

  • miR-15 and miR-16 induce apoptosis by targeting BCL2.

    Amelia Cimmino;George Adrian Calin;Muller Fabbri;Marilena V. Iorio

  • MiR-15a and miR-16-1 cluster functions in human leukemia.

    George A. Calin;Amelia Cimmino;Muller Fabbri;Manuela Ferracin

  • miR-15a and miR-16-1 in cancer: discovery, function and future perspectives

    R I Aqeilan;G A Calin;C M Croce

  • MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis

    Flavia Pichiorri;Sung Suk Suh;Marco Ladetto;Michael Kuehl

  • Biological Functions of miR-29b Contribute to Positive Regulation of Osteoblast Differentiation

    Zhaoyong Li;Mohammad Q. Hassan;Mohammed Jafferji;Rami I. Aqeilan

  • Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development

    Flavia Pichiorri;Flavia Pichiorri;Sung Suk Suh;Sung Suk Suh;Alberto Rocci;Luciana De Luca

  • MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia

    R. Garzon;F. Pichiorri;T. Palumbo;T. Palumbo;M. Visentini

  • Reprogramming of miRNA networks in cancer and leukemia

    Stefano Volinia;Marco Galasso;Stefan Costinean;Luca Tagliavini

  • miRNA Signatures Associate with Pathogenesis and Progression of Osteosarcoma

    Kevin B. Jones;Zaidoun Salah;Sara Del Mare;Marco Galasso

  • Functional association between Wwox tumor suppressor protein and p73, a p53 homolog

    Rami I. Aqeilan;Yuri Pekarsky;Juan J. Herrero;Alexey Palamarchuk

  • The E3 ubiquitin ligase Itch controls the protein stability of p63

    Mario Rossi;Rami I. Aqeilan;Michael Neale;Eleonora Candi

  • Targeted deletion of Wwox reveals a tumor suppressor function.

    Rami I. Aqeilan;Francesco Trapasso;Sadiq Hussain;Stefan Costinean

  • WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function.

    Rami I. Aqeilan;Valentina Donati;Alexey Palamarchuk;Francesco Trapasso

  • Physical and Functional Interactions between the Wwox Tumor Suppressor Protein and the AP-2γ Transcription Factor

    Rami I. Aqeilan;Alexey Palamarchuk;Ronald J. Weigel;Juan J. Herrero

  • Itch: a HECT-type E3 ligase regulating immunity, skin and cancer.

    G Melino;E Gallagher;Rami I Aqeilan;R Knight

  • Akt Phosphorylates and Regulates Pdcd4 Tumor Suppressor Protein

    Alexey Palamarchuk;Alexey Efanov;Vadim Maximov;Rami I. Aqeilan

  • WWOX gene restoration prevents lung cancer growth in vitro and in vivo

    Muller Fabbri;Dimitrios Iliopoulos;Francesco Trapasso;Rami I. Aqeilan

  • The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis

    Tamotsu Kuroki;Sai Yendamuri;Francesco Trapasso;Ayumi Matsuyama

  • WWOX in biological control and tumorigenesis.

    Rami I. Aqeilan;Carlo M. Croce

  • Loss of WWOX Expression in Gastric Carcinoma

    Rami I. Aqeilan;Tamotsu Kuroki;Yuri Pekarsky;Omar Albagha

Frequent Co-Authors

Carlo M. Croce
Carlo M. Croce The Ohio State University
Stefano Volinia
Stefano Volinia University of Ferrara
Kay Huebner
Kay Huebner The Ohio State University
Hansjuerg Alder
Hansjuerg Alder The Ohio State University
Gary S. Stein
Gary S. Stein University of Vermont
Jane B. Lian
Jane B. Lian University of Vermont
George A. Calin
George A. Calin The University of Texas MD Anderson Cancer Center
Gerry Melino
Gerry Melino University of Rome Tor Vergata
Massimo Negrini
Massimo Negrini University of Ferrara
Janet L. Stein
Janet L. Stein University of Vermont

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