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Zofia M.A. Chrzanowska-Lightowlers

Zofia M.A. Chrzanowska-Lightowlers

D-Index & Metrics

Biology and Biochemistry

D-Index
47
Citations
7225
World Ranking
18755
National Ranking
1460

Overview

Zofia M.A. Chrzanowska-Lightowlers is affiliated with Newcastle University in the United Kingdom. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to mitochondrial function, RNA and protein synthesis mechanisms, and RNA modifications in cancer. They have published extensively in these areas, exploring detailed mechanisms related to mitochondria and molecular synthesis processes.

Their work spans several specialized subfields including molecular biology, clinical biochemistry, genetics, surgery, and ecology. The main research topics covered by their publications include:

  • Mitochondrial Function and Pathology
  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • Metabolism and Genetic Disorders
  • ATP Synthase and ATPases Research
  • Bacterial Genetics and Biotechnology
  • Coenzyme Q10 studies and effects

Their recent published papers include:

  • "Mitochondrial transplantation-a possible therapeutic for mitochondrial dysfunction?" (2020) published in EMBO Reports
  • "High-resolution imaging reveals compartmentalization of mitochondrial protein synthesis in cultured human cells" (2021) published in Proceedings of the National Academy of Sciences
  • "Rescuing stalled mammalian mitoribosomes - what can we learn from bacteria?" (2020) published in Journal of Cell Science
  • "Messenger RNA delivery to mitoribosomes - hints from a bacterial toxin" (2020) published in FEBS Journal
  • "Visualizing Mitochondrial Ribosomal RNA and Mitochondrial Protein Synthesis in Human Cell Lines" (2020) published in Methods in molecular biology

Zofia collaborates frequently with several researchers, including Robert N. Lightowlers, Rolando Berlinguer-Palmini, Matthew Zorkau, Christin A. Albus, and Robert W. Taylor. These coauthors have appeared in multiple joint publications, indicating ongoing collaborative research efforts.

Their findings have been published repeatedly in venues such as bioRxiv (Cold Spring Harbor Laboratory), Methods in molecular biology, FEBS Journal, EMBO Reports, and Proceedings of the National Academy of Sciences. These platforms reflect their focus on molecular and cellular biology research.

Best Publications

  • Mitochondrial dysfunction in a cell culture model of familial amyotrophic lateral sclerosis.

    Fiona M Menzies;Mark R Cookson;Robert W Taylor;Douglass M Turnbull

  • Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

    Haoran Tai;Zhe Wang;Hui Gong;Xiaojuan Han

  • Human mitochondrial mRNAs--like members of all families, similar but different.

    Richard J. Temperley;Mateusz Wydro;Robert N. Lightowlers;Zofia M. Chrzanowska-Lightowlers

  • GRSF1 Regulates RNA Processing in Mitochondrial RNA Granules

    Alexis A. Jourdain;Mirko Koppen;Mateusz Wydro;Chris D. Rodley

  • Hungry codons promote frameshifting in human mitochondrial ribosomes.

    Richard Temperley;Ricarda Richter;Sven Dennerlein;Robert N. Lightowlers

  • Nuclear DNA-encoded tRNAs targeted into mitochondria can rescue a mitochondrial DNA mutation associated with the MERRF syndrome in cultured human cells

    Olga A. Kolesnikova;Nina S. Entelis;Clarisse Jacquin-Becker;Francine Goltzene

  • A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome

    Ricarda Richter;Joanna Rorbach;Aleksandra Pajak;Paul M Smith

  • Mutations in C12orf65 in Patients with Encephalomyopathy and a Mitochondrial Translation Defect

    Hana Antonicka;Elsebet Østergaard;Florin Sasarman;Woranontee Weraarpachai

  • Messenger RNA stability in mitochondria: different means to an end

    Dominique Gagliardi;Piotr P Stepien;Richard J Temperley;Robert N Lightowlers

  • Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit.

    Sven Dennerlein;Agata Rozanska;Mateusz Wydro;Zofia M. A. Chrzanowska-Lightowlers

  • mtRF1a Is a Human Mitochondrial Translation Release Factor Decoding the Major Termination Codons UAA and UAG

    Hamid Reza Soleimanpour-Lichaei;Inge Kühl;Mauricette Gaisne;Joao F. Passos

  • Store-Operated Ca2+ Entry Controls Induction of Lipolysis and the Transcriptional Reprogramming to Lipid Metabolism.

    Mate Maus;Mario Cuk;Bindi Patel;Jayson Lian

  • Molecular basis of infantile reversible cytochrome c oxidase deficiency myopathy

    Rita Horvath;John P. Kemp;Helen A. L. Tuppen;Gavin Hudson

  • The process of mammalian mitochondrial protein synthesis

    Nicole Mai;Zofia M. A. Chrzanowska-Lightowlers;Robert N. Lightowlers

  • The human mitochondrial ribosome recycling factor is essential for cell viability

    Joanna Rorbach;Ricarda Richter;Hans J. Wessels;Mateusz Wydro

  • Investigation of a pathogenic mtDNA microdeletion reveals a translation-dependent deadenylation decay pathway in human mitochondria

    Richard J. Temperley;Sara H. Seneca;Katarzyna Tonska;Ewa Bartnik

  • Inhibition of mitochondrial protein synthesis promotes increased stability of nuclear-encoded respiratory gene transcripts.

    Z. M. A. Chrzanowska-Lightowlers;T. Preiss;R. N. Lightowlers

  • Mutations in mitochondrial ribosomal protein MRPL12 leads to growth retardation, neurological deterioration and mitochondrial translation deficiency.

    Valérie Serre;Agata Rozanska;Marine Beinat;Dominique Chretien

  • An mtDNA Mutation in the Initiation Codon of the Cytochrome C Oxidase Subunit II Gene Results in Lower Levels of the Protein and a Mitochondrial Encephalomyopathy

    Kim M. Clark;Robert W. Taylor;Margaret A. Johnson;Patrick F. Chinnery

  • in Patients with Encephalomyopathy and a Mitochondrial Translation Defect

    Hana Antonicka;Elsebet Østergaard;Florin Sasarman;Woranontee Weraarpachai

Frequent Co-Authors

Robert N. Lightowlers
Robert N. Lightowlers Newcastle University
Robert W. Taylor
Robert W. Taylor Newcastle University
Robert McFarland
Robert McFarland Newcastle University
Douglass M. Turnbull
Douglass M. Turnbull Newcastle University
Laurence A. Bindoff
Laurence A. Bindoff Haukeland University Hospital
Charlotte L. Alston
Charlotte L. Alston Newcastle University
Patrick F. Chinnery
Patrick F. Chinnery University of Cambridge
Thomas Preiss
Thomas Preiss Australian National University
Holger Prokisch
Holger Prokisch Technical University of Munich
Rita Horvath
Rita Horvath University of Cambridge

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