World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
78
Citations
20717
World Ranking
18095
National Ranking
9023

Overview

Lary C. Walker is affiliated with Emory University in the United States and has contributed extensively to research in medicine, neuroscience, and biochemistry, genetics, and molecular biology. Their work spans multiple subfields, including physiology, molecular biology, neurology, cognitive neuroscience, and cellular and molecular neuroscience.

The primary research topics covered by Walker focus on Alzheimer's disease research and treatments, prion diseases and protein misfolding, neuroinflammation and neurodegeneration mechanisms, memory and neural mechanisms, neuroscience and neuropharmacology research, tryptophan and brain disorders, and phagocytosis and immune regulation.

Walker has published in several prominent venues, reflecting a diverse engagement with the scientific community. These venues include:

  • Brain Structure and Function
  • Cell
  • Nature
  • Nature Neuroscience
  • PubMed

Their recent papers provide insight into ongoing contributions in their field. Selected recent publications are:

  • "Alzheimer's disease: From immunotherapy to immunoprevention," 2023, Cell
  • "Medin co-aggregates with vascular amyloid-β in Alzheimer's disease," 2022, Nature
  • "Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life," 2020, Nature Neuroscience
  • "Aβ plaques," 2020, PubMed
  • "Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae," 2022, Nature Communications

Walker has collaborated frequently with a core group of researchers, including:

  • Mathias Jucker
  • Angelos Skodras
  • Ulrike Obermüller
  • Rebecca F. Rosen
  • Chet C. Sherwood

Best Publications

  • Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

    Mathias Jucker;Lary C. Walker;Lary C. Walker

  • Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.

    Melanie Meyer-Luehmann;Janaky Coomaraswamy;Tristan Bolmont;Tristan Bolmont;Stephan Kaeser

  • Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders.

    Mathias Jucker;Lary C. Walker

  • Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis

    Yvonne S. Eisele;Ulrike Obermüller;Ulrike Obermüller;Götz Heilbronner;Götz Heilbronner;Frank Baumann;Frank Baumann

  • Evidence for Seeding of β-Amyloid by Intracerebral Infusion of Alzheimer Brain Extracts in β-Amyloid Precursor Protein-Transgenic Mice

    Michael D. Kane;William J. Lipinski;Michael J. Callahan;Feng Bian

  • Deposition of Alzheimer's β-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans

    Silke Vogelgesang;Ingolf Cascorbi;Eike Schroeder;Jens Pahnke

  • Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases.

    Mathias Jucker;Lary C. Walker

  • Neurodegenerative Diseases: Expanding the Prion Concept

    Lary C. Walker;Mathias Jucker

  • Age-Dependent Impairment of Mitochondrial Function in Primate Brain

    A C Bowling;E M Mutisya;L C Walker;D L Price

  • Aged monkeys exhibit behavioral deficits indicative of widespread cerebral dysfunction.

    Jocelyne Bachevalier;Linda S. Landis;Lary C. Walker;Mimi Brickson

  • Augmented Senile Plaque Load in Aged Female β-Amyloid Precursor Protein-Transgenic Mice

    Michael J. Callahan;William J. Lipinski;Feng Bian;Robert A. Durham

  • Induction of cerebral β-amyloidosis: Intracerebral versus systemic Aβ inoculation

    Yvonne S. Eisele;Tristan Bolmont;Mathias Heikenwalder;Franziska Langer

  • Accelerated Glial Reactivity to Stroke in Aged Rats Correlates With Reduced Functional Recovery

    I Badan;B Buchhold;A Hamm;M Gratz

  • Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys

    Gary L. Wenk;Lary C. Walker;Donald L. Price;Linda C. Cork

  • MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer’s Amyloid-β Peptides—Implications for the Mechanisms of Aβ Clearance at the Blood–Brain Barrier

    Diana Kuhnke;Gabriele Jedlitschky;Markus Grube;Markus Krohn

  • Amyloid-Associated Neuron Loss and Gliogenesis in the Neocortex of Amyloid Precursor Protein Transgenic Mice

    Luca Bondolfi;Michael Calhoun;Florian Ermini;H. Georg Kuhn

  • Mechanisms of protein seeding in neurodegenerative diseases.

    Lary C. Walker;Marc I. Diamond;Karen E. Duff;Bradley T. Hyman

  • Soluble Aβ Seeds Are Potent Inducers of Cerebral β-Amyloid Deposition

    Franziska Langer;Yvonne S. Eisele;Sarah K. Fritschi;Matthias Staufenbiel

  • Abnormalities of the nucleus basalis in Down's syndrome.

    Manuel F. Casanova;Lary C. Walker;Peter J. Whitehouse;Donald L. Price

  • Loss of pedunculopontine neurons in progressive supranuclear palsy.

    Richard M. Zweig;Peter J. Whitehouse;Manuel F. Casanova;Lary C. Walker

Frequent Co-Authors

Donald L. Price
Donald L. Price Johns Hopkins University
Linda C. Cork
Linda C. Cork Stanford University
Harry LeVine
Harry LeVine University of Kentucky
Cheryl A. Kitt
Cheryl A. Kitt Johns Hopkins University School of Medicine
Matthias Staufenbiel
Matthias Staufenbiel University of Tübingen
Lee J. Martin
Lee J. Martin Johns Hopkins University School of Medicine
Sangram S. Sisodia
Sangram S. Sisodia University of Chicago
Mathias Jucker
Mathias Jucker University of Tübingen
Sam Gandy
Sam Gandy Icahn School of Medicine at Mount Sinai
Vassilis E. Koliatsos
Vassilis E. Koliatsos Johns Hopkins University School of Medicine

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