World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
76
Citations
16704
World Ranking
5144
National Ranking
2450

Research.com Recognitions

  • 1985 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Irwin M. Arias is affiliated with the National Institutes of Health in the United States. Their research primarily spans the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Business, Management and Accounting. The scientist has a focus on subfields such as Nephrology, Physiology, and Management Information Systems.

Their work includes a concentration on topics related to renal health and systemic conditions affecting kidney function. Specifically, Irwin M. Arias has contributed to the understanding of:

  • Renal Diseases and Glomerulopathies
  • Chronic Kidney Disease and Diabetes
  • Adenosine and Purinergic Signaling
  • Logistics and Transportation Systems

Among their recent publications is the article titled Adenosine A2B Receptor Antagonism Interferes with TGF-β Cellular Signaling Through SMAD2/-3 and p65-Nf-κB in Podocytes and Protects from Phenotypical Transformation in Experimental Diabetic Glomerulopathy, published in 2025 in the journal Cells. This paper explores cellular signaling mechanisms relevant to diabetic glomerulopathy.

Irwin M. Arias's frequent collaborators include:

  • Claudia Jara
  • Pablo Mendoza
  • Yéssica Nahuelpán
  • Claudio Cappelli
  • Carlos Oyarzún

Their work has been published mainly in the journal Cells, highlighting a targeted dissemination of research findings within this venue.

In recognition of their professional standing, Irwin M. Arias is a Fellow of the American Association for the Advancement of Science (AAAS), an honor received in 1985. They are also a member of the Association of American Physicians, underscoring their engagement with prominent professional scientific societies.

Best Publications

  • The identity of glutathione S-transferase B with ligandin, a major binding protein of liver.

    William H. Habig;Michael J. Pabst;Gerald Fleischner;Zenaida Gatmaitan

  • The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles.

    Y Kamimoto;Z Gatmaitan;J Hsu;I M Arias

  • Chronic nonhemolytic unconjugated hyperbilirubinemia with glucuronyl transferase deficiency: Clinical, biochemical, pharmacologic and genetic evidence for heterogeneity

    Irwin M. Arias;Lawrence M. Gartner;Michael I. Cohen;Judith Ben Ezzer

  • Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia.

    Tsuneo Kitamura;Peter Jansen;Cheryl Hardenbrook;Yukio Kamimoto

  • Structural and functional hepatocyte polarity and liver disease.

    Paul Gissen;Paul Gissen;Paul Gissen;Irwin M. Arias

  • CHRONIC UNCONJUGATED HYPERBILIRUBINEMIA WITHOUT OVERT SIGNS OF HEMOLYSIS IN ADOLESCENTS AND ADULTS

    Irwin M. Arias

  • Rat liver canalicular membrane vesicles contain an ATP-dependent bile acid transport system.

    Toshirou Nishida;Zenaida Gatmaitan;Mingxin Che;Irwin M. Arias

  • Prolonged Neonatal Unconjugated Hyperbilirubinemia Associated with Breast Feeding and a Steroid, Pregnane-3 (Alpha), 20 (Beta)-Diol, in Maternal Milk That Inhibits Glucuronide Formation In Vitro*

    Irwin M. Arias;Lawrence M. Gartner;Sam Seifter;Mathilda Furman

  • Inherited Disorders of Bilirubin Transport and Conjugation: New Insights Into Molecular Mechanisms and Consequences

    Serge Erlinger;Irwin M. Arias;Daniel Dhumeaux

  • Taurocholate Transport by Rat Liver Sinusoidal Membrane Vesicles: Evidence of Sodium Cotransport

    Masayasu Inoue;Rolf Kinne;Thao Tran;Irwin M. Arias

  • Transporters on demand: intrahepatic pools of canalicular ATP binding cassette transporters in rat liver

    Helmut Kipp;Nipaporn Pichetshote;Irwin M. Arias

  • Rat liver canalicular membrane vesicles. Isolation and topological characterization.

    M Inoue;R Kinne;T Tran;L Biempica

  • Primary Structure and Functional Expression of a cDNA Encoding the Bile Canalicular, Purine-specific Na-Nucleoside Cotransporter

    Mingxin Che;Daniel F. Ortiz;Irwin M. Arias

  • The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa

    Shu Hsing;Zenaida Gatmaitan;Irwin M. Arias

  • Rab11a and myosin Vb are required for bile canalicular formation in WIF-B9 cells

    Yoshiyuki Wakabayashi;Parmesh Dutt;Jennifer Lippincott-Schwartz;Irwin M. Arias

  • Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization

    Andrew R Cullinane;Anna Straatman-Iwanowska;Andreas Zaucker;Yoshiyuki Wakabayashi

  • Newly synthesized canalicular ABC transporters are directly targeted from the Golgi to the hepatocyte apical domain in rat liver.

    Helmut Kipp;Irwin M. Arias

  • Electrophysiological properties of gap junctions between dissociated pairs of rat hepatocytes.

    D C Spray;R D Ginzberg;E A Morales;Z Gatmaitan

  • The biology of the P-glycoproteins

    C R Leveille-Webster;I M Arias

  • Trafficking of canalicular ABC transporters in hepatocytes.

    Helmut Kipp;Irwin M. Arias

Frequent Co-Authors

Jennifer Lippincott-Schwartz
Jennifer Lippincott-Schwartz Howard Hughes Medical Institute
Lyuba Varticovski
Lyuba Varticovski National Institutes of Health
Paul Gissen
Paul Gissen University College London
David G. Le Couteur
David G. Le Couteur University of Sydney
John B. Robbins
John B. Robbins National Institutes of Health
Eamonn R. Maher
Eamonn R. Maher University of Cambridge
Allan W. Wolkoff
Allan W. Wolkoff Albert Einstein College of Medicine
Hartwig Wolburg
Hartwig Wolburg University of Tübingen
J. Silvio Gutkind
J. Silvio Gutkind University of California, San Diego
Deirdre A. Kelly
Deirdre A. Kelly University of Birmingham

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