Linda J. Van Eldik mainly investigates Cell biology, Astrocyte, Immunology, Neuroglia and Microglia. The Cell biology study combines topics in areas such as Secretion, Nitric oxide synthase, Neurodegeneration and P3 peptide. She focuses mostly in the field of Neurodegeneration, narrowing it down to matters related to Presenilin and, in some cases, Senile plaques.
Her work deals with themes such as Inflammation, Occipital lobe, Biochemistry and Cerebellum, which intersect with Astrocyte. Linda J. Van Eldik has researched Neuroglia in several fields, including Neurotrophin and MAPK/ERK pathway, p38 mitogen-activated protein kinases. Her studies in Microglia integrate themes in fields like Proinflammatory cytokine and Receptor.
Cell biology, Biochemistry, Neuroinflammation, Microglia and Neuroscience are her primary areas of study. Her Cell biology research is multidisciplinary, incorporating elements of Nitric oxide synthase and Astrocyte. Her research in Neuroinflammation focuses on subjects like Proinflammatory cytokine, which are connected to Downregulation and upregulation, Neurodegeneration, Central nervous system and Cancer research.
Her Microglia study combines topics from a wide range of disciplines, such as Interleukin, Cytokine, Neuroglia, Prostaglandin and Amyloid. Her research in Amyloid intersects with topics in P3 peptide and Amyloid precursor protein. Her Neuroscience study integrates concerns from other disciplines, such as Alzheimer's disease and Drug discovery.
Linda J. Van Eldik focuses on Proinflammatory cytokine, Immunology, Cell biology, Cytokine and Chemokine. Her Proinflammatory cytokine research includes elements of Neuroinflammation, MAPK/ERK pathway and Drug discovery. Her Immunology study deals with Central nervous system intersecting with Drug target and Multiple sclerosis.
Her study in p38 mitogen-activated protein kinases and Protein kinase A is carried out as part of her studies in Cell biology. Linda J. Van Eldik regularly ties together related areas like Microglia in her Cytokine studies. Her Inflammation research incorporates elements of Peripheral and Endocrinology.
Her primary areas of study are Immunology, Proinflammatory cytokine, Chemokine, Cell biology and Microglia. The various areas that she examines in her Immunology study include Drug target, Neuroscience, Central nervous system and Pharmacoinformatics. Her research integrates issues of Cytokine, Downregulation and upregulation, CCL7 and MAPK/ERK pathway, p38 mitogen-activated protein kinases in her study of Proinflammatory cytokine.
Her Chemokine study combines topics in areas such as Cell culture, Phagocyte, Phagocytosis, Neuroglia and Apoptosis. Her study ties her expertise on Macrophage together with the subject of Cell biology. Her study in Microglia is interdisciplinary in nature, drawing from both Neuroinflammation and Neuroprotection.
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Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.
Holly Oakley;Sarah L. Cole;Sreemathi Logan;Erika Maus.
The Journal of Neuroscience (2006)
The Janus face of glial-derived S100B: beneficial and detrimental functions in the brain.
Linda J. Van Eldik;Mark S. Wainwright.
Restorative Neurology and Neuroscience (2003)
β-Amyloid Stimulation of Inducible Nitric-oxide Synthase in Astrocytes Is Interleukin-1β- and Tumor Necrosis Factor-α (TNFα)-dependent, and Involves a TNFα Receptor-associated Factor- and NFκB-inducing Kinase-dependent Signaling Mechanism *
Keith T. Akama;Linda J. Van Eldik.
Journal of Biological Chemistry (2000)
S100β Induces Neuronal Cell Death Through Nitric Oxide Release from Astrocytes
Jingru Hu;Adriana Ferreira;Linda J. Van Eldik.
Journal of Neurochemistry (2002)
Epithelial myosin light chain kinase–dependent barrier dysfunction mediates T cell activation–induced diarrhea in vivo
Daniel R. Clayburgh;Terrence A. Barrett;Yueming Tang;Jon B. Meddings.
Journal of Clinical Investigation (2005)
Cyclopentenone prostaglandins suppress activation of microglia: Down-regulation of inducible nitric-oxide synthase by 15-deoxy-Δ12,14-prostaglandin J2
Tatiana V. Petrova;Keith T. Akama;Linda J. Van Eldik.
Proceedings of the National Academy of Sciences of the United States of America (1999)
Amyloid-β peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release
Jingru Hu;Keith T Akama;Grant A Krafft;Grant A Krafft;Brett A Chromy.
Brain Research (1998)
S100β Stimulates Inducible Nitric Oxide Synthase Activity and mRNA Levels in Rat Cortical Astrocytes
Jingru Hu;Francis Castets;José L. Guevara;Linda J. Van Eldik.
Journal of Biological Chemistry (1996)
Differential effects of oligomeric and fibrillar amyloid-β1–42 on astrocyte-mediated inflammation
Jill A. White;Arlene M. Manelli;Kristina H. Holmberg;Kristina H. Holmberg;Linda J. Van Eldik.
Neurobiology of Disease (2005)
Targeting protein kinases in central nervous system disorders
Laura K. Chico;Linda J. Van Eldik;D. Martin Watterson.
Nature Reviews Drug Discovery (2009)
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