World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
19583
World Ranking
7700
National Ranking
3509

Overview

Linda J. Van Eldik is affiliated with the University of Kentucky in the United States. Their research contributions are primarily situated within the field of Medicine, with a focus on several specialized subfields including Neurology, Physiology, Psychiatry and Mental Health, Molecular Biology, and Immunology.

The scientist's work centers on key topics such as Alzheimer's disease research and treatments, dementia and cognitive impairment research, neuroinflammation and neurodegeneration mechanisms, cholinesterase and neurodegenerative diseases, neurological disease mechanisms and treatments, S100 proteins and annexins, and traumatic brain injury and neurovascular disturbances.

Frequent publication venues for Van Eldik include:

  • Alzheimer's & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Acta Neuropathologica Communications
  • Journal of Neuroinflammation
  • Journal of Neuropathology & Experimental Neurology

Recent papers highlight the scientist's focus on neurodegenerative conditions and brain injury, with notable publications such as:

  • "Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults" (2020) in JAMA Neurology
  • "Brain arteriolosclerosis" (2020) in Acta Neuropathologica
  • "Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice" (2020) in Journal of Neuroinflammation
  • "Neurodegenerative pathologies associated with behavioral and psychological symptoms of dementia in a community-based autopsy cohort" (2023) in Acta Neuropathologica Communications
  • "The effects of mild closed head injuries on tauopathy and cognitive deficits in rodents: Primary results in wild type and rTg4510 mice, and a systematic review" (2020) in Experimental Neurology

Van Eldik has collaborated extensively with several coauthors, including:

  • Gregory A. Jicha
  • Erin L. Abner
  • Peter T. Nelson
  • Frederick A. Schmitt
  • Donna M. Wilcock

Best Publications

  • Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

    Holly Oakley;Sarah L. Cole;Sreemathi Logan;Erika Maus

  • The Janus face of glial-derived S100B: beneficial and detrimental functions in the brain.

    Linda J. Van Eldik;Mark S. Wainwright

  • β-Amyloid Stimulation of Inducible Nitric-oxide Synthase in Astrocytes Is Interleukin-1β- and Tumor Necrosis Factor-α (TNFα)-dependent, and Involves a TNFα Receptor-associated Factor- and NFκB-inducing Kinase-dependent Signaling Mechanism *

    Keith T. Akama;Linda J. Van Eldik

  • S100β Induces Neuronal Cell Death Through Nitric Oxide Release from Astrocytes

    Jingru Hu;Adriana Ferreira;Linda J. Van Eldik

  • Epithelial myosin light chain kinase–dependent barrier dysfunction mediates T cell activation–induced diarrhea in vivo

    Daniel R. Clayburgh;Terrence A. Barrett;Yueming Tang;Jon B. Meddings

  • Alzheimer’s disease is not “brain aging”: neuropathological, genetic, and epidemiological human studies

    Peter T. Nelson;Elizabeth Head;Frederick A. Schmitt;Paulina R. Davis

  • Cyclopentenone prostaglandins suppress activation of microglia: Down-regulation of inducible nitric-oxide synthase by 15-deoxy-Δ12,14-prostaglandin J2

    Tatiana V. Petrova;Keith T. Akama;Linda J. Van Eldik

  • Amyloid-β peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release

    Jingru Hu;Keith T Akama;Grant A Krafft;Grant A Krafft;Brett A Chromy

  • Targeting protein kinases in central nervous system disorders

    Laura K. Chico;Linda J. Van Eldik;D. Martin Watterson

  • Nascent Astrocyte Particles Differ from Lipoproteins in CSF

    M. J. LaDu;S. M. Gilligan;J. R. Lukens;V. G. Cabana

  • Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1β production

    Seon H. Kim;Carolyn J. Smith;Linda J. Van Eldik

  • Differential effects of oligomeric and fibrillar amyloid-β1–42 on astrocyte-mediated inflammation

    Jill A. White;Arlene M. Manelli;Kristina H. Holmberg;Kristina H. Holmberg;Linda J. Van Eldik

  • S100 beta stimulates inducible nitric oxide synthase activity and mRNA levels in rat cortical astrocytes.

    Jingru Hu;Francis Castets;José L. Guevara;Linda J. Van Eldik

  • A novel p38α MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model

    Lenka Munoz;Lenka Munoz;Hantamalala Ralay Ranaivo;Saktimayee M Roy;Wenhui Hu;Wenhui Hu

  • S100β expression in Alzheimer's disease: Relation to neuropathology in brain regions

    Linda J. Van Eldik;W.Sue T. Griffin

  • Lipoproteins in the Central Nervous System

    Mary Jo Ladu;Catherine Reardon;Linda Van Eldik;Anne M. Fagan

  • Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease.

    Elaine R Peskind;W.Sue T Griffin;Keith T Akama;Murray A Raskind

  • Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-7 through NFκB and MAPK dependent pathways in rat astrocytes

    Wendy L. Thompson;Linda J. Van Eldik

  • Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury

    Eric Lloyd;Kathleen Somera-Molina;Kathleen Somera-Molina;Linda J Van Eldik;D Martin Watterson

  • A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity.

    Ling Guo;Mary Jo LaDu;Mary Jo LaDu;Linda J. Van Eldik

Frequent Co-Authors

D. Martin Watterson
D. Martin Watterson Northwestern University
Mary Jo LaDu
Mary Jo LaDu University of Illinois at Chicago
Jacques Haiech
Jacques Haiech University of Strasbourg
Tatiana V. Petrova
Tatiana V. Petrova University of Lausanne
Alexander Marks
Alexander Marks University of Toronto
Steven W. Barger
Steven W. Barger University of Arkansas for Medical Sciences
Guojun Bu
Guojun Bu Hong Kong University of Science and Technology
Godfrey S. Getz
Godfrey S. Getz University of Chicago
Konstantin G. Birukov
Konstantin G. Birukov University of Chicago
Gordon C. K. Roberts
Gordon C. K. Roberts University of Leicester

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