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D-Index & Metrics

Biology and Biochemistry

D-Index
76
Citations
23323
World Ranking
5001
National Ranking
2402

Overview

Douglas L. Feinstein is affiliated with the University of Illinois at Chicago in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology. Feinstein's work often intersects several key subfields including molecular biology, ecology, emergency medicine, neurology, and physiology.

The scientist's research interests cover a variety of topics, notably:

  • Animal Ecology and Behavior Studies
  • Poisoning and overdose treatments
  • Multiple Sclerosis Research Studies
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Extracellular vesicles in disease
  • MicroRNA in disease regulation
  • Tryptophan and brain disorders

Feinstein has contributed to several scientific publications, including the following recent papers:

  • Neuroinflammation in Alzheimer disease, 2024, published in Nature Reviews. Immunology
  • Uptake and Distribution of Administered Bone Marrow Mesenchymal Stem Cell Extracellular Vesicles in Retina, 2021, published in Cells
  • MicroRNA-based engineering of mesenchymal stem cell extracellular vesicles for treatment of retinal ischemic disorders, 2023, published in Acta Biomaterialia
  • Investigating the metabolite signature of an altered oral microbiota as a discriminant factor for multiple sclerosis: a pilot study, 2024, published in Scientific Reports
  • Emerging concepts in the treatment of optic neuritis: mesenchymal stem cell-derived extracellular vesicles, 2021, published in Stem Cell Research & Therapy

Their frequent collaborators include:

  • Anne I. Boullerne
  • Richard B. van Breemen
  • Israel Rubinstein
  • Sergey Kalinin
  • Elizabeth A. Boots

The majority of Feinstein's publications appear in the following journals and venues:

  • Toxicology Communications
  • ASN NEURO
  • Journal of Neuroimmunology
  • Research Square
  • bioRxiv

Douglas L. Feinstein's research portfolio reflects a multidisciplinary approach, contributing to fields that overlap between fundamental molecular studies and applied clinical research. This includes investigations into neurodegenerative disease mechanisms, the role of microRNAs and extracellular vesicles in treatment strategies, and metabolic markers in neurological disorders. The diversity of publication venues and frequent collaboration with other researchers indicate an active engagement in advancing both basic and translational biomedical sciences.

Best Publications

  • Neuroinflammation in Alzheimer's disease

    Michael T Heneka;Monica J Carson;Joseph El Khoury;Gary E Landreth

  • Synthesis of nitric oxide in CNS glial cells.

    Sean Murphy;Martha L. Simmons;Luis Agullo;Agustina Garcia

  • Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity

    Guy L. Weinberg;Richard Ripper;Douglas L. Feinstein;William Hoffman

  • Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine

    Elena Galea;S. Regunathan;Vassily Eliopoulos;Douglas L. Feinstein

  • Heat Shock Protein 70 Suppresses Astroglial-inducible Nitric-oxide Synthase Expression by Decreasing NFκB Activation *

    Douglas L. Feinstein;Elena Galea;Dennis A. Aquino;Gloria C. Li

  • Peroxisome proliferator‐activated receptor‐γ agonists prevent experimental autoimmune encephalomyelitis

    Douglas L. Feinstein;Elena Galea;Vitality Gavrilyuk;Celia F. Brosnan

  • Receptor-independent actions of PPAR thiazolidinedione agonists: Is mitochondrial function the key?

    D.L. Feinstein;A. Spagnolo;C. Akar;G. Weinberg

  • Peroxisome Proliferator-Activated Receptor-γ Ligands Reduce Neuronal Inducible Nitric Oxide Synthase Expression and Cell DeathIn Vivo

    Michael T. Heneka;Michael T. Heneka;Thomas Klockgether;Douglas L. Feinstein

  • Expression and function of inducible nitric oxide synthase in neurons.

    Michael T. Heneka;Douglas L. Feinstein

  • Noradrenergic Depletion Potentiates β-Amyloid-Induced Cortical Inflammation: Implications for Alzheimer's Disease

    Michael T. Heneka;Elena Galea;Vitality Gavriluyk;Lucia Dumitrescu-Ozimek

  • Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents.

    Kudret Tureyen;Ramya Kapadia;Kellie K. Bowen;Irawan Satriotomo

  • Noradrenergic regulation of inflammatory gene expression in brain

    Douglas L Feinstein;Michael T Heneka;Vitaliy Gavrilyuk;Cinzia Dello Russo

  • p38 MAPK-mediated Transcriptional Activation of Inducible Nitric-oxide Synthase in Glial Cells ROLES OF NUCLEAR FACTORS, NUCLEAR FACTOR κB, cAMP RESPONSE ELEMENT-BINDING PROTEIN, CCAAT/ENHANCER-BINDING PROTEIN-β, AND ACTIVATING TRANSCRIPTION FACTOR-2

    Narayan R. Bhat;Douglas L. Feinstein;Qin Shen;Aruna N. Bhat

  • Cloning and expression of inducible nitric oxide synthase from rat astrocytes.

    E. Galea;D. J. Reis;D. L. Feinstein

  • Noradrenaline deficiency in brain increases β-amyloid plaque burden in an animal model of Alzheimer's disease

    Sergey A. Kalinin;Vitaliy Gavrilyuk;Paul E. Polak;Robert Vasser

  • P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis

    Anthony J Sharp;Paul E Polak;Vittoria Simonini;Shao X Lin

  • The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes

    Lucia Lisi;Pierluigi Navarra;Douglas L Feinstein;Cinzia Dello Russo

  • Neuronal and glial coexpression of argininosuccinate synthetase and inducible nitric oxide synthase in Alzheimer disease.

    Michael T. Heneka;Heinrich Wiesinger;Lucia Dumitrescu-Ozimek;Peter Riederer

  • Peroxisome Proliferator-activated Receptor γ Thiazolidinedione Agonists Increase Glucose Metabolism in Astrocytes

    Cinzia Dello Russo;Cinzia Dello Russo;Vitaliy Gavrilyuk;Guy Weinberg;Guy Weinberg;Angeles Almeida

  • Neuroinfl ammation in Alzheimer's disease

    Michael T Heneka;Monica J Carson;Joseph El Khoury;Gary E Landreth

Frequent Co-Authors

Elena Galea
Elena Galea Autonomous University of Barcelona
Michael T. Heneka
Michael T. Heneka University Hospital Bonn
Donald J. Reis
Donald J. Reis Cornell University
Richard B. van Breemen
Richard B. van Breemen Oregon State University
Gary E. Landreth
Gary E. Landreth Indiana University
Rajesh Khanna
Rajesh Khanna University of Florida
Alexei Verkhratsky
Alexei Verkhratsky University of Manchester
Narayan R. Bhat
Narayan R. Bhat Medical University of South Carolina
Jill C. Richardson
Jill C. Richardson MSD (United Kingdom)
Stephen D. Schmidt
Stephen D. Schmidt National Institutes of Health

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