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Murray L. Whitelaw

Murray L. Whitelaw

D-Index & Metrics

Biology and Biochemistry

D-Index
47
Citations
13526
World Ranking
18567
National Ranking
544

Overview

Murray L. Whitelaw is affiliated with the University of Adelaide in Australia, where they conduct research primarily in the field of Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Molecular Biology, Genetics, Cancer Research, Biomedical Engineering, and Physiology.

Their research addresses multiple topics, with a focus on:

  • Epigenetics and DNA Methylation
  • Cancer, Hypoxia, and Metabolism
  • Genetics and Neurodevelopmental Disorders
  • Genomics and Rare Diseases
  • Single-cell and spatial transcriptomics
  • Mitochondrial Function and Pathology
  • Congenital heart defects research

Whitelaw's recent publications illustrate a concentration on genetic and molecular mechanisms associated with neurological and developmental disorders, as well as protein functionality. Notable papers include:

  • Structural Models for the Dynamic Effects of Loss-of-Function Variants in the Human SIM1 Protein Transcriptional Activation Domain (2020), published in Biomolecules
  • Molecular characterisation of rare loss-of-function NPAS3 and NPAS4 variants identified in individuals with neurodevelopmental disorders (2021), published in Scientific Reports
  • Core and Flanking bHLH-PAS:DNA interactions mediate specificity and drive obesity (2022), published in bioRxiv (Cold Spring Harbor Laboratory)
  • Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes (2022), published in Biochemical Journal
  • Proteoliposomes reconstituted with human aquaporin-1 reveal novel single-ion-channel properties (2023), published in Biophysical Reports

Their publication record shows engagement with multiple scientific venues, particularly with repeated contributions to:

  • Biomolecules
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports
  • Biochemical Journal
  • Biophysical Reports

Collaboration is a significant aspect of their work, with frequent co-authors including Daniel J. Peet, David C. Bersten, John B. Bruning, Alison E. Roennfeldt, and Timothy P. Allen. These collaborations suggest cross-disciplinary interactions within related areas of molecular biology and genetics.

Best Publications

  • Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch.

    David Lando;Daniel J. Peet;Dean A. Whelan;Jeffrey J. Gorman

  • FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

    David Lando;Daniel J. Peet;Jeffrey J. Gorman;Dean A. Whelan

  • The mammalian basic helix-loop-helix/PAS family of transcriptional regulators.

    Robyn J Kewley;Murray L Whitelaw;Anne Chapman-Smith

  • Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor.

    K Gradin;J McGuire;R H Wenger;I Kvietikova

  • A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors

    Patrik Andersson;Jacqueline McGuire;Carlos Rubio;Katarina Gradin

  • The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses.

    Bracken Cp;Whitelaw Ml;Peet Dj

  • Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

    Xiaofeng Zheng;Sarah Linke;José M. Dias;Xiaowei Zheng

  • Cell-specific regulation of hypoxia-inducible factor (HIF)-1α and HIF-2α stabilization and transactivation in a graded oxygen environment

    Cameron P. Bracken;Anthony O. Fedele;Sarah Linke;Wiltiana Balrak

  • bHLH–PAS proteins in cancer

    David C. Bersten;Adrienne E. Sullivan;Daniel J. Peet;Murray L. Whitelaw

  • Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor.

    Murray Whitelaw;Ingemar Pongratz;Anna Wilhelmsson;Jan-Ake Gustafsson

  • Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex.

    M.C. Lindebro;L. Poellinger;M.L. Whitelaw

  • Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation.

    David Lando;Jeffrey J. Gorman;Murray L. Whitelaw;Daniel J. Peet

  • Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: Inducible versus constitutive modes of regulation

    Murray L. Whitelaw;Jan Åke Gustafsson;Lorenz Poellinger

  • A Redox Mechanism Controls Differential DNA Binding Activities of Hypoxia-inducible Factor (HIF) 1α and the HIF-like Factor *

    David Lando;Ingemar Pongratz;Lorenz Poellinger;Murray L. Whitelaw

  • The emerging roles of AhR in physiology and immunity.

    Nan Hao;Murray L Whitelaw

  • Definition of a novel ligand binding domain of a nuclear bHLH receptor: co-localization of ligand and hsp90 binding activities within the regulable inactivation domain of the dioxin receptor

    Murray L. Whitelaw;Martin Göttlicher;Jan-Ake Gustafsson;Lorenz Poellinger

  • Cross-coupling of signal transduction pathways: the dioxin receptor mediates induction of cytochrome P-450IA1 expression via a protein kinase C-dependent mechanism.

    A Berghard;K Gradin;I Pongratz;M Whitelaw

  • Definition of a minimal domain of the dioxin receptor that is associated with Hsp90 and maintains wild type ligand binding affinity and specificity

    Pascal Coumailleau;Lorenz Poellinger;Jan-Åke Gustafsson;Murray L. Whitelaw;Murray L. Whitelaw

  • Evidence that the 90-kDa heat shock protein (HSP90) exists in cytosol in heteromeric complexes containing HSP70 and three other proteins with Mr of 63,000, 56,000, and 50,000.

    Gary H. Perdew;Murray L. Whitelaw

  • Degradation of the basic helix-loop-helix/Per-ARNT-Sim homology domain dioxin receptor via the ubiquitin/proteasome pathway.

    Ben J. Roberts;Murray L. Whitelaw

Frequent Co-Authors

Lorenz Poellinger
Lorenz Poellinger Karolinska Institute
Jan-Åke Gustafsson
Jan-Åke Gustafsson University of Houston
Lorenz Poellinger
Lorenz Poellinger Karolinska Institute
Philippe Froguel
Philippe Froguel Imperial College London
Inês Barroso
Inês Barroso University of Exeter
Stephen O'Rahilly
Stephen O'Rahilly University of Cambridge
Peter E. Clayton
Peter E. Clayton University of Manchester
Soren Brage
Soren Brage University of Cambridge
Mehul T. Dattani
Mehul T. Dattani University College London
I. Sadaf Farooqi
I. Sadaf Farooqi University of Cambridge

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