His main research concerns Transcription factor, Biochemistry, Aryl hydrocarbon receptor nuclear translocator, Transactivation and Hypoxia-inducible factors. His biological study spans a wide range of topics, including Signal transduction and Cell biology. His research on Biochemistry focuses in particular on Regulation of gene expression.
His work carried out in the field of Aryl hydrocarbon receptor nuclear translocator brings together such families of science as Transcription factor complex and Receptor. Murray L. Whitelaw focuses mostly in the field of Receptor, narrowing it down to matters related to Hsp90 and, in some cases, Immunoprecipitation. His Transactivation research integrates issues from Hypoxia-Inducible Factor-Proline Dioxygenases and Oxygen homeostasis.
Transcription factor, Aryl hydrocarbon receptor nuclear translocator, Biochemistry, Cell biology and Receptor are his primary areas of study. His studies in Transcription factor integrate themes in fields like Molecular biology and Response element. He interconnects Hsp90, PAS domain, Signal transduction and DNA in the investigation of issues within Aryl hydrocarbon receptor nuclear translocator.
His is involved in several facets of Biochemistry study, as is seen by his studies on 5-HT5A receptor, Asparagine, Nuclear receptor, Glucocorticoid receptor and Mutant. His research integrates issues of Regulation of gene expression, Dioxin Receptor, Transcription and Gene knockdown in his study of Cell biology. His Basic helix-loop-helix study combines topics in areas such as Sequence motif and Repressor.
Murray L. Whitelaw mostly deals with Transcription factor, Aryl hydrocarbon receptor nuclear translocator, Genetics, SIM1 and Loss function. His biological study focuses on Basic helix-loop-helix. The Basic helix-loop-helix study combines topics in areas such as H3K4me3, Neuron differentiation, Repressor and DNA methylation.
His Aryl hydrocarbon receptor nuclear translocator study combines topics from a wide range of disciplines, such as Hypoxia-inducible factors, Cytokine and FOXP3. His research in SIM1 intersects with topics in Endocrinology, Obesity, Internal medicine, Haploinsufficiency and SIM2. Murray L. Whitelaw has researched Bioinformatics in several fields, including Oxygen homeostasis, Physiology and HIF1A.
The scientist’s investigation covers issues in Aryl hydrocarbon receptor nuclear translocator, SIM1, Aryl hydrocarbon receptor, Transcription factor and Loss function. Murray L. Whitelaw has included themes like Immunology, Immune system, Cytokine and Cytotoxic T cell, Antigen-presenting cell in his Aryl hydrocarbon receptor nuclear translocator study. His SIM1 research also works with subjects such as
His study in Aryl hydrocarbon receptor is interdisciplinary in nature, drawing from both Regulator, FOXP3, Computational biology and Function. His Transcription factor study integrates concerns from other disciplines, such as Cell signaling, Circadian clock and Cell biology. His Loss function research is multidisciplinary, incorporating perspectives in Young adult, Chromosome, Obesity and Case-control study.
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Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch.
David Lando;Daniel J. Peet;Dean A. Whelan;Jeffrey J. Gorman.
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
David Lando;Daniel J. Peet;Jeffrey J. Gorman;Dean A. Whelan.
Genes & Development (2002)
The mammalian basic helix-loop-helix/PAS family of transcriptional regulators.
Robyn J Kewley;Murray L Whitelaw;Anne Chapman-Smith.
The International Journal of Biochemistry & Cell Biology (2004)
A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors
Patrik Andersson;Jacqueline McGuire;Carlos Rubio;Katarina Gradin.
Proceedings of the National Academy of Sciences of the United States of America (2002)
The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses.
C. P. Bracken;M. L. Whitelaw;D. J. Peet.
Cellular and Molecular Life Sciences (2003)
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways
Xiaofeng Zheng;Sarah Linke;José M. Dias;Xiaowei Zheng.
Proceedings of the National Academy of Sciences of the United States of America (2008)
Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex.
M.C. Lindebro;L. Poellinger;M.L. Whitelaw.
The EMBO Journal (1995)
Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor.
Murray Whitelaw;Ingemar Pongratz;Anna Wilhelmsson;Jan-Ake Gustafsson.
Molecular and Cellular Biology (1993)
Cell-specific regulation of hypoxia-inducible factor (HIF)-1α and HIF-2α stabilization and transactivation in a graded oxygen environment
Cameron P. Bracken;Anthony O. Fedele;Sarah Linke;Wiltiana Balrak.
Journal of Biological Chemistry (2006)
Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation.
David Lando;Jeffrey J. Gorman;Murray L. Whitelaw;Daniel J. Peet.
FEBS Journal (2003)
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