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Medicine

D-Index
89
Citations
25309
World Ranking
12812
National Ranking
145

Overview

Markku Seppälä is affiliated with Helsinki University Hospital in Finland and works primarily within the field of Medicine. Their research encompasses several subfields including Physiology, Immunology, Obstetrics and Gynecology, Epidemiology, and Pediatrics, Perinatology and Child Health.

Seppälä's work is notably focused on topics related to the reproductive system and pregnancy. Key areas of study include pregnancy and preeclampsia, preterm birth and chorioamnionitis, as well as adipose tissue and metabolism. Research on diet and metabolism and studies concerning birth, development, and health are also prominent in their output.

The scientist has contributed to multiple academic publications. Some of the recent papers include:

  • Decidual glycodelin-A polarizes human monocytes into a decidual macrophage-like phenotype through Siglec-7, 2020, Journal of Cell Science
  • Biologically Informed Polygenic Scores for Brain Insulin Receptor Network Are Associated with Cardiometabolic Risk Markers and Diabetes in Women, 2024, Diabetes & Metabolism Journal

Frequent collaborators in Seppälä's work include Hannu Koistinen, Madhavi Vijayan, Cheuk-Lun Lee, Vera H.H. Wong, and Xia Wang. The scientist has published in venues such as the Journal of Cell Science and the Diabetes & Metabolism Journal.

Best Publications

  • Insulin Regulates the Serum Levels of Low Molecular Weight Insulin-Like Growth Factor-Binding Protein*

    Anne-Maria Suikkari;Veikko A. Koivisto;Eeva-Marja Rutanen;Hannele Yki-Järvinen

  • Pregnancy-specific beta-glycoprotein in complications of early pregnancy.

    Jouppila P;Seppälä M;Chard T

  • Studies of carcino-fetal proteins. 3. Development of a radioimmunoassay for -fetoprotein. Demonstration of -fetoprotein in serum of healthy human adults.

    Erkki Ruoslahti;Markku Seppälä

  • alpha-Fetoprotein in cancer and fetal development.

    Erkki Ruoslahti;Markku Seppälä

  • Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3.

    M Harrela;H Koistinen;J Kaprio;M Lehtovirta

  • Endometrial stromal cells regulate epithelial cell growth in vitro: a new co-culture model

    Julia T. Arnold;David G. Kaufman;Markku Seppälä;Bruce A. Lessey

  • Alpha-fetoprotein in antenatal diagnosis.

    Markku Seppälä;Erkki Ruoslahti

  • Structural analysis of the oligosaccharides derived from glycodelin, a human glycoprotein with potent immunosuppressive and contraceptive activities.

    Anne Dell;Howard R. Morris;Richard L. Easton;Maria Panico

  • Glycodelin: A Major Lipocalin Protein of the Reproductive Axis with Diverse Actions in Cell Recognition and Differentiation

    Markku Seppälä;Robert N. Taylor;Hannu Koistinen;Riitta Koistinen

  • Suppression by human placental protein 14 of natural killer cell activity.

    Norihiko Okamoto;Atsushi Uchida;Kenji Takakura;Yoshitaka Kariya

  • Secretory endometrium synthesizes placental protein 14.

    Mervi Julkunen;Riitta Koistinen;Jari Sjöberg;Eeva-Marja Rutanen

  • Ovarian cancer antigen CA 125 levels in pelvic inflammatory disease and pregnancy.

    Hannu Halila;Ulf‐Hǎkan Stenman;Markku Seppälä

  • Placental protein 12 is a decidual protein that binds somatomedin and has an identical N-terminal amino acid sequence with somatomedin-binding protein from human amniotic fluid.

    Riitta Koistinen;Nisse Kalkkinen;Marja-Liisa Huhtala;Markku Seppala

  • Diet-induced changes in sex hormone binding globulin and free testosterone in women with normal or polycystic ovaries: correlation with serum insulin and insulin-like growth factor-I.

    D. S. Kiddy;D. Hamilton-Fairley;M. Seppälä;R. Koistinen

  • Insulin Reduction with Metformin Increases Luteal Phase Serum Glycodelin and Insulin-Like Growth Factor-Binding Protein 1 Concentrations and Enhances Uterine Vascularity and Blood Flow in the Polycystic Ovary Syndrome

    Daniela J. Jakubowicz;Markku Seppälä;Salomon Jakubowicz;Otto Rodriguez-Armas

  • Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA

    M. Julkunen;R. Koistinen;K. Aalto-Setala;M. Seppala

  • Immunosuppression during pregnancy: Transmission of azathioprine and its metabolites from the mother to the fetus

    Seppo Saarikoski;Markku Seppälä

  • Factors affecting fertilization: endometrial placental protein 14 reduces the capacity of human spermatozoa to bind to the human zona pellucida*†

    Sergio Oehninger;Charles C. Coddington;Gary D. Hodgen;Markku Seppala

  • Gender-specific Glycosylation of Human Glycodelin Affects Its Contraceptive Activity

    Howard R. Morris;Anne Dell;Richard L. Easton;Maria Panico

  • A twin study of polycystic ovary syndrome.

    Shayesteh Jahanfar;John A. Eden;Peter Warren;Markku Seppälä

Frequent Co-Authors

Ulf-Håkan Stenman
Ulf-Håkan Stenman University of Helsinki
Erkki Ruoslahti
Erkki Ruoslahti Sanford Burnham Prebys Medical Discovery Institute
Sergio Oehninger
Sergio Oehninger Stellenbosch University
Howard R. Morris
Howard R. Morris Imperial College London
Anne Dell
Anne Dell Imperial College London
Hannele Yki-Järvinen
Hannele Yki-Järvinen University of Helsinki
Leif C. Andersson
Leif C. Andersson University of Helsinki
Olli A. Jänne
Olli A. Jänne University of Helsinki
Bruce A. Lessey
Bruce A. Lessey Wake Forest Baptist Medical Center
Sakari Knuutila
Sakari Knuutila University of Helsinki

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