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Molecular Biology

D-Index
62
Citations
12255
World Ranking
1858
National Ranking
928

Research.com Recognitions

  • 2016 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Paul Babitzke is affiliated with Pennsylvania State University in the United States. Their research focuses broadly within Biochemistry, Genetics, and Molecular Biology, with notable contributions in molecular biology and genetics.

The scientist's main areas of research include RNA and protein synthesis mechanisms, bacterial genetics and biotechnology, RNA research and splicing, RNA modifications and cancer, bacteriophages and microbial interactions, genomics and phylogenetic studies, and enzyme structure and function.

Paul Babitzke's frequent coauthors include Helen Yakhnin, Zachary F. Mandell, Mikhail Kashlev, Alexander V. Yakhnin, and Philip C. Bevilacqua.

Their work has appeared regularly in several scientific publication venues, including bioRxiv (Cold Spring Harbor Laboratory), Nucleic Acids Research, Journal of Bacteriology, Proceedings of the National Academy of Sciences, and mBio.

Among the published papers authored or coauthored by Paul Babitzke are:

  • Diverse Mechanisms and Circuitry for Global Regulation by the RNA-Binding Protein CsrA, 2020, Frontiers in Microbiology
  • NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA, 2021, eLife
  • NusG controls transcription pausing and RNA polymerase translocation throughout the Bacillus subtilis genome, 2020, Proceedings of the National Academy of Sciences
  • Expression of Bacillus subtilis ABCF antibiotic resistance factor VmlR is regulated by RNA polymerase pausing, transcription attenuation, translation attenuation and (p)ppGpp, 2022, Nucleic Acids Research
  • Comprehensive transcription terminator atlas for Bacillus subtilis, 2022, Nature Microbiology

Paul Babitzke has contributed substantially to research on bacterial transcription regulation, RNA polymerase function, and antibiotic resistance mechanisms in Bacillus subtilis. Their studies often focus on transcription termination factors such as NusG and global regulatory RNA-binding proteins like CsrA.

In recognition of their scientific contributions, Paul Babitzke was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2016.

Best Publications

  • New method for generating deletions and gene replacements in Escherichia coli.

    Carol Hamilton;M Aldea;BK Washburn;P Babitzke

  • CsrB sRNA family: sequestration of RNA-binding regulatory proteins.

    Paul Babitzke;Tony Romeo

  • Positive regulation of motility and flhDC expression by the RNA-binding protein CsrA of Escherichia coli

    Bangdong L. Wei;Anne Marie Brun-Zinkernagel;Jerry W. Simecka;Birgit M. Prüß

  • A novel sRNA component of the carbon storage regulatory system of Escherichia coli.

    Thomas Weilbacher;Kazushi Suzuki;Ashok K. Dubey;Xin Wang

  • CsrA post‐transcriptionally represses pgaABCD, responsible for synthesis of a biofilm polysaccharide adhesin of Escherichia coli

    Xin Wang;Ashok K. Dubey;Kazushi Suzuki;Carol S. Baker

  • Regulatory Circuitry of the CsrA/CsrB and BarA/UvrY Systems of Escherichia coli

    Kazushi Suzuki;Xin Wang;Thomas Weilbacher;Anna Karin Pernestig

  • Post-transcriptional regulation on a global scale: form and function of Csr/Rsm systems

    Tony Romeo;Christopher A. Vakulskas;Paul Babitzke

  • CsrA regulates glycogen biosynthesis by preventing translation of glgC in Escherichia coli.

    Carol S. Baker;Igor Morozov;Kazushi Suzuki;Tony Romeo

  • Regulation of Bacterial Virulence by Csr (Rsm) Systems

    Christopher A. Vakulskas;Anastasia H. Potts;Paul Babitzke;Brian M. M. Ahmer

  • Identification of a novel regulatory protein (CsrD) that targets the global regulatory RNAs CsrB and CsrC for degradation by RNase E

    Kazushi Suzuki;Paul Babitzke;Sidney R. Kushner;Tony Romeo

  • RNA sequence and secondary structure participate in high-affinity CsrA–RNA interaction

    Ashok K. Dubey;Carol S. Baker;Tony Romeo;Paul Babitzke

  • The Ams (altered mRNA stability) protein and ribonuclease E are encoded by the same structural gene of Escherichia coli

    Paul Babitzke;Sidney R. Kushner

  • CsrA Regulates Translation of the Escherichia coli Carbon Starvation Gene, cstA, by Blocking Ribosome Access to the cstA Transcript

    Ashok K. Dubey;Carol S. Baker;Kazushi Suzuki;A. Daniel Jones

  • Circuitry linking the Csr and stringent response global regulatory systems

    Adrianne N. Edwards;Laura M. Patterson-Fortin;Christopher A. Vakulskas;Jeffrey W. Mercante

  • Reconstitution of Bacillus subtilis trp attenuation in vitro with TRAP, the trp RNA-binding attenuation protein.

    Paul Babitzke;Charles Yanofsky

  • CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage.

    Alexander V. Yakhnin;Carol S. Baker;Christopher A. Vakulskas;Helen Yakhnin

  • Integration of a complex regulatory cascade involving the SirA/BarA and Csr global regulatory systems that controls expression of the Salmonella SPI-1 and SPI-2 virulence regulons through HilD.

    Luary C. Martínez;Helen Yakhnin;Martha I. Camacho;Dimitris Georgellis

  • Complexity in Regulation of Tryptophan Biosynthesis in Bacillus subtilis

    Paul Gollnick;Paul Babitzke;Alfred Antson;Charles Yanofsky

  • Regulation of Translation Initiation by RNA Binding Proteins

    Paul Babitzke;Carol S. Baker;Tony Romeo

  • Regulatory Interactions of Csr Components: the RNA Binding Protein CsrA Activates csrB Transcription in Escherichia coli

    Seshagirirao Gudapaty;Kazushi Suzuki;Xin Wang;Paul Babitzke

Frequent Co-Authors

Tony Romeo
Tony Romeo University of Florida
Philip C. Bevilacqua
Philip C. Bevilacqua Pennsylvania State University
Charles Yanofsky
Charles Yanofsky Stanford University
Mikhail Kashlev
Mikhail Kashlev National Institutes of Health
Daniel B. Kearns
Daniel B. Kearns Indiana University
Sidney R. Kushner
Sidney R. Kushner University of Georgia
Sarah M. Assmann
Sarah M. Assmann Pennsylvania State University
Katsuhiko S. Murakami
Katsuhiko S. Murakami Pennsylvania State University
Thomas K. Wood
Thomas K. Wood Pennsylvania State University
Dieter Haas
Dieter Haas University of Lausanne

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