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Chemistry

D-Index
88
Citations
23955
World Ranking
2330
National Ranking
832

Research.com Recognitions

  • 1980 - Fellow of Alfred P. Sloan Foundation

Overview

Stanley J. Opella is a researcher affiliated with the University of California, San Diego in the United States. Their work spans multiple domains of medicine and biochemistry, genetics, and molecular biology, with notable emphasis on infectious diseases, molecular biology, spectroscopy, epidemiology, and genetics.

The scientist's research has contributed to several main topics, including:

  • Advanced NMR Techniques and Applications
  • Protein Structure and Dynamics
  • SARS-CoV-2 and COVID-19 Research
  • Infectious Encephalopathies and Encephalitis
  • Lipid Membrane Structure and Behavior
  • Yersinia bacterium, plague, ectoparasites research
  • Clostridium difficile and Clostridium perfringens research

Stanley J. Opella's frequent collaborators include Sang Ho Park, Anna A. De Angelis, Yong Yao, Chandan Singh, and Francesca M. Marassi. Their publications commonly appear in venues such as bioRxiv (Cold Spring Harbor Laboratory), Journal of Magnetic Resonance, Biophysical Journal, Biochemistry, and PLoS Pathogens.

Recent papers authored by or involving the researcher highlight work across structural biology and virology:

  • Interactions of SARS-CoV-2 envelope protein with amilorides correlate with antiviral activity (2021), published in PLoS Pathogens
  • Membrane proteins in magnetically aligned phospholipid polymer discs for solid-state NMR spectroscopy (2020), published in Biochimica et Biophysica Acta (BBA) - Biomembranes
  • 3D printed sample tubes for solid-state NMR experiments (2021), published in Journal of Magnetic Resonance
  • Correlating the Structure and Activity of Y. pestis Ail in a Bacterial Cell Envelope (2020), published in Biophysical Journal
  • Differences in Oligomerization of the SARS-CoV-2 Envelope Protein, Poliovirus VP4, and HIV Vpu (2024), published in Biochemistry

Their research contributions predominantly focus on the application of nuclear magnetic resonance (NMR) spectroscopy to study membrane proteins, viral envelope proteins, and bacterial components, providing insights relevant to infectious disease mechanisms and antiviral strategies.

Stanley J. Opella was recognized as a Fellow of the Alfred P. Sloan Foundation in 1980, which marks a significant milestone in their scientific career.

Best Publications

  • Selection of nonprotonated carbon resonances in solid-state nuclear magnetic resonance

    S. J. Opella;M. H. Frey

  • Structure of the chemokine receptor CXCR1 in phospholipid bilayers

    Sang Ho Park;Bibhuti B. Das;Fabio Casagrande;Ye Tian;Ye Tian

  • High-Resolution Heteronuclear Dipolar Solid-State NMR Spectroscopy

    C.H. Wu;A. Ramamoorthy;S.J. Opella

  • Structure determination of membrane proteins by NMR spectroscopy.

    Stanley J. Opella;Francesca M. Marassi

  • Structure and orientation of the antibiotic peptide magainin in membranes by solid-state nuclear magnetic resonance spectroscopy.

    Burkhard Bechinger;Michael Zasloff;Stanley J. Opella

  • A solid-state NMR index of helical membrane protein structure and topology.

    Francesca M Marassi;Stanley J Opella

  • Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy.

    S.J. Opella;F.M. Marassi;F.M. Marassi;J.J. Gesell;J.J. Gesell;A.P. Valente;A.P. Valente

  • Two-dimensional 1H NMR experiments show that the 23-residue magainin antibiotic peptide is an alpha-helix in dodecylphosphocholine micelles, sodium dodecylsulfate micelles, and trifluoroethanol/water solution.

    Jennifer Gesell;Michael Zasloff;Stanley J. Opella

  • Three-dimensional Structure of the Channel-forming Trans-membrane Domain of Virus Protein “u” (Vpu) from HIV-1

    Sang Ho Park;Anthony A. Mrse;Alexander A. Nevzorov;Michael F. Mesleh

  • Molecular and structural information from 14N–13C dipolar couplings manifested in high resolution 13C NMR spectra of solids

    J. G. Hexem;M. H. Frey;S. J. Opella

  • NMR and membrane proteins.

    Opella Sj

  • Solid-state NMR structural studies of peptides and proteins in membranes

    T.A. Cross;S.J. Opella

  • Trapping the dynamic acyl carrier protein in fatty acid biosynthesis

    Chi Nguyen;Robert W. Haushalter;D. John Lee;Phineus R. L. Markwick;Phineus R. L. Markwick;Phineus R. L. Markwick

  • Complete resolution of the solid-state NMR spectrum of a uniformly 15N-labeled membrane protein in phospholipid bilayers

    Francesca M. Marassi;A. Ramamoorthy;Stanley J. Opella

  • Detection of individual carbon resonances in solid proteins

    S. J. Opella;M. H. Frey;T. A. Cross

  • Protein structure by solid-state NMR spectroscopy.

    S. J. Opella;Phoebe L. Stewart;K. G. Valentine

  • Simultaneous assignment and structure determination of a membrane protein from NMR orientational restraints

    Francesca M. Marassi;Stanley J. Opella

  • Structures of the Reduced and Mercury-Bound Forms of MerP, the Periplasmic Protein from the Bacterial Mercury Detoxification System†,‡

    Ruth A. Steele;Stanley J. Opella

  • Tilt angle of a trans-membrane helix is determined by hydrophobic mismatch.

    Sang Ho Park;Stanley J. Opella

  • High Resolution Solid State 13C NMR Spectroscopy of Sporopollenins from Different Plant Taxa

    William J. Guilford;Diane M. Schneider;Jeffrey Labovitz;Stanley J. Opella

Frequent Co-Authors

Timothy A. Cross
Timothy A. Cross Florida State University
Lila M. Gierasch
Lila M. Gierasch University of Massachusetts Amherst
Ayyalusamy Ramamoorthy
Ayyalusamy Ramamoorthy Florida State University
Roger E. Koeppe
Roger E. Koeppe University of Arkansas at Fayetteville
Gianluigi Veglia
Gianluigi Veglia University of Minnesota
Oleg Jardetzky
Oleg Jardetzky Stanford University
Phoebe L. Stewart
Phoebe L. Stewart Case Western Reserve University
John C. Guatelli
John C. Guatelli University of California, San Diego
Raz Jelinek
Raz Jelinek Ben-Gurion University of the Negev
Mauricio Montal
Mauricio Montal University of California, San Diego

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