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Immunology

D-Index
51
Citations
10467
World Ranking
4139
National Ranking
1889

Overview

Hernan Valdez is affiliated with Pfizer in the United States and has contributed extensively to the field of medicine, with a particular focus on dermatology and related subfields. Their research portfolio includes 136 publications in medicine, involving specialized areas such as dermatology, immunology and allergy, physiology, and rheumatology. Valdez's work encompasses a range of topics primarily centered on dermatology and skin diseases, allergic rhinitis and sensitization, asthma and respiratory diseases, pharmaceutical studies and practices, urticaria and related conditions, transgenic plants and applications, and food allergy and anaphylaxis research.

The scientist's research output includes numerous articles published in prominent journals. Their frequent publication venues include the Journal of the American Academy of Dermatology, American Journal of Clinical Dermatology, Journal of the European Academy of Dermatology and Venereology, Annals of Allergy Asthma & Immunology, and the Journal of Allergy and Clinical Immunology.

Among Hernan Valdez's notable recent papers are:

  • Efficacy and safety of abrocitinib in adults and adolescents with moderate-to-severe atopic dermatitis (JADE MONO-1): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial (2020, The Lancet)
  • Abrocitinib versus Placebo or Dupilumab for Atopic Dermatitis (2021, New England Journal of Medicine)
  • Efficacy and Safety of Abrocitinib in Patients With Moderate-to-Severe Atopic Dermatitis (2020, JAMA Dermatology)
  • Incidence of venous and arterial thromboembolic events reported in the tofacitinib rheumatoid arthritis, psoriasis and psoriatic arthritis development programmes and from real-world data (2020, Annals of the Rheumatic Diseases)
  • Efficacy and safety of abrocitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis: a randomised, double-blind, multicentre phase 3 trial (2022, The Lancet)

Throughout their career, Valdez has frequently collaborated with other researchers, including Ricardo Rojo, Marco DiBonaventura, Jonathan I. Silverberg, Claire Feeney, and Eric L. Simpson. These partnerships have contributed to a body of work with a strong interdisciplinary approach, particularly focused on dermatology and immunological conditions.

Best Publications

  • Efficacy and safety of abrocitinib in adults and adolescents with moderate-to-severe atopic dermatitis (JADE MONO-1): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial.

    Eric L Simpson;Rodney Sinclair;Seth Forman;Andreas Wollenberg

  • Durable efficacy of tipranavir-ritonavir in combination with an optimised background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at 48 weeks in the Randomized Evaluation of Strategic Intervention in multi-drug reSistant patients with Tipranavir (RESIST) studies: an analysis of combined data from two randomised open-label trials

    Charles B Hicks;Pedro Cahn;David A Cooper;Sharon L Walmsley

  • Abrocitinib versus Placebo or Dupilumab for Atopic Dermatitis.

    Thomas Bieber;Eric L. Simpson;Jonathan I. Silverberg;Diamant Thaçi

  • Tofacitinib versus etanercept or placebo in moderate-to-severe chronic plaque psoriasis: a phase 3 randomised non-inferiority trial

    Unknown

  • Efficacy and Safety of Abrocitinib in Patients With Moderate-to-Severe Atopic Dermatitis: A Randomized Clinical Trial.

    Jonathan I. Silverberg;Eric L. Simpson;Jacob P. Thyssen;Melinda J. Gooderham

  • Continued CD4 cell count increases in HIV-infected adults experiencing 4 years of viral suppression on antiretroviral therapy.

    Peter W. Hunt;Steven G. Deeks;Benigno Rodriguez;Hernan Valdez

  • Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function

    Luciléia Teixeira;Hernan Valdez;Joseph M. McCune;Richard A. Koup

  • Limited immune restoration after 3 years' suppression of HIV-1 replication in patients with moderately advanced disease.

    Hernan Valdez;Elizabeth Connick;Elizabeth Connick;Kimberly Y. Smith;Kimberly Y. Smith;Michael M. Lederman

  • Tuberculosis and other opportunistic infections in tofacitinib-treated patients with rheumatoid arthritis

    Kevin L. Winthrop;S. H. Park;A. Gul;M. H. Cardiel

  • Efficacy and safety of abrocitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis: a randomised, double-blind, multicentre phase 3 trial

    Unknown

  • Thymic Size and Lymphocyte Restoration in Patients with Human Immunodeficiency Virus Infection after 48 Weeks of Zidovudine, Lamivudine, and Ritonavir Therapy

    Kimberly Y. Smith;H. Valdez;A. Landay;J. Spritzler

  • Nadir CD4+ T-cell count and numbers of CD28+ CD4+ T-cells predict functional responses to immunizations in chronic HIV-1 infection

    Christoph G Lange;Michael M Lederman;Kathy Medvik;Robert Asaad

  • Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic.

    Dong Zhang;Premlata Shankar;Premlata Shankar;Zhan Xu;Zhan Xu;Brooke Harnisch;Brooke Harnisch

  • Selective impairments in dendritic cell-associated function distinguish hepatitis C virus and HIV infection.

    Donald D Anthony;Nicole L. Yonkers;Anthony B Post;Robert Asaad

  • CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection.

    Gang Chen;Premlata Shankar;Christoph Lange;Hernan Valdez

  • Response to immunization with recall and neoantigens after prolonged administration of an HIV-1 protease inhibitor-containing regimen

    Hernan Valdez;Kimberly Y. Smith;Alan Landay;Elizabeth Connick

  • Immune recovery is associated with persistent rise in hepatitis C virus RNA, infrequent liver test flares, and is not impaired by hepatitis C virus in co-infected subjects.

    Raymond T. Chung;Scott R. Evans;Yijun Yang;Dickens Theodore

  • Immune restoration with antiretroviral therapies: implications for clinical management.

    Michael Marcel Lederman;Hernan Valdez

  • Incidence of venous and arterial thromboembolic events reported in the tofacitinib rheumatoid arthritis, psoriasis and psoriatic arthritis development programmes and from real-world data.

    Philip Mease;Christina Charles-Schoeman;Stanley Cohen;Lara Fallon

  • Changing Spectrum of Mortality Due to Human Immunodeficiency Virus: Analysis of 260 Deaths during 1995–1999

    Hernan Valdez;Tanvir K. Chowdhry;Robert Asaad;Ian J. Woolley

  • Deep sequencing to infer HIV-1 co-receptor usage: application to three clinical trials of maraviroc in treatment-experienced patients

    Luke C. Swenson;Theresa Mo;Winnie W.Y. Dong;Xiaoyin Zhong

  • Population-based V3 Genotypic Tropism Assay: A Retrospective Analysis Using Screening Samples From the A4001029 and MOTIVATE Studies

    Rachel A McGovern;Alexander Thielen;Theresa Mo;Winnie Dong

  • Nelfinavir, efavirenz, or both after the failure of nucleoside treatment of HIV infection.

    Mary A. Albrecht;Ronald J. Bosch;Scott M. Hammer;Song-Heng Liou

  • Tofacitinib withdrawal and retreatment in moderate-to-severe chronic plaque psoriasis: a randomized controlled trial.

    R Bissonnette;Lars Iversen;H Sofen;C E M Griffiths

  • Tofacitinib attenuates pathologic immune pathways in patients with psoriasis: A randomized phase 2 study

    James Krueger;James D. Clark;Mayte Suárez-Fariñas;Judilyn Fuentes-Duculan

  • Efficacy and Safety of Abrocitinib in Combination With Topical Therapy in Adolescents With Moderate-to-Severe Atopic Dermatitis: The JADE TEEN Randomized Clinical Trial.

    Lawrence F Eichenfield;Carsten Flohr;Robert Sidbury;Elaine Siegfried

  • Abrocitinib induction, randomized withdrawal, and retreatment in patients with moderate-to-severe atopic dermatitis: Results from the JAK1 Atopic Dermatitis Efficacy and Safety (JADE) REGIMEN phase 3 trial.

    Andrew Blauvelt;Jonathan I. Silverberg;Charles W. Lynde;Thomas Bieber

Frequent Co-Authors

Michael M. Lederman
Michael M. Lederman Case Western Reserve University
Alan L. Landay
Alan L. Landay The University of Texas Medical Branch at Galveston
Daniel R. Kuritzkes
Daniel R. Kuritzkes Brigham and Women's Hospital
Christoph Lange
Christoph Lange University of Lübeck
Benigno Rodriguez
Benigno Rodriguez Case Western Reserve University
Harold A. Kessler
Harold A. Kessler Rush University Medical Center
Robert A. Salata
Robert A. Salata Case Western Reserve University
Grace A. McComsey
Grace A. McComsey Case Western Reserve University
Richard B. Pollard
Richard B. Pollard University of California, Davis
David Katzenstein
David Katzenstein Stanford University

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