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Biology and Biochemistry

D-Index
116
Citations
44222
World Ranking
759
National Ranking
478

Overview

Tomas Kirchhausen is affiliated with Boston Children's Hospital in the United States. Their research spans multiple fields, primarily focusing on biochemistry, genetics, molecular biology, and medicine. The scientist has contributed significantly to subfields such as molecular biology, infectious diseases, cell biology, biophysics, and neurology.

The main topics covered in their work include:

  • SARS-CoV-2 and COVID-19 Research
  • Cellular transport and secretion
  • Advanced Fluorescence Microscopy Techniques
  • Advanced Electron Microscopy Techniques and Applications
  • Cell Image Analysis Techniques
  • Viral Infections and Outbreaks Research
  • Lipid Membrane Structure and Behavior

Recent notable publications by Tomas Kirchhausen include:

  • HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation, 2020, Science
  • Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells, 2020, Science
  • Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion, 2020, Proceedings of the National Academy of Sciences
  • Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2, 2020, Proceedings of the National Academy of Sciences
  • A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility, 2022, Cell

The scientist frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, The Journal of Cell Biology, Biophysical Journal, and Science.

Collaborations have been an integral part of their work, with frequent co-authors including:

  • Alex J.B. Kreutzberger
  • Gustavo Scanavachi
  • Anwesha Sanyal
  • Srigokul Upadhyayula
  • Elliott Somerville

Best Publications

  • Dynasore, a Cell-Permeable Inhibitor of Dynamin

    Eric Macia;Marcelo Ehrlich;Ramiro Massol;Emmanuel Boucrot

  • The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly.

    Rajat Rohatgi;Le Ma;Hiroaki Miki;Marco Lopez

  • Interaction of tyrosine-based sorting signals with clathrin-associated proteins

    Hiroshi Ohno;Jay Stewart;Marie-Christine Fournier;Herbert Bosshart

  • Endocytosis by Random Initiation and Stabilization of Clathrin-Coated Pits

    Marcelo Ehrlich;Werner Boll;Antoine van Oijen;Ramesh Hariharan

  • Three ways to make a vesicle

    Tomas Kirchhausen

  • Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics

    Dong Li;Lin Shao;Bi-Chang Chen;Xi Zhang;Xi Zhang

  • Adaptors for Clathrin-Mediated Traffic

    Tomas Kirchhausen

  • A Rab Protein Is Required for the Assembly of SNARE Complexes in the Docking of Transport Vesicles

    Morten Søgaard;Katsuko Tani;R.Ruby Ye;Scott Geromanos

  • Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

    Anders Wittrup;Angela Ai;Xing Liu;Peter Hamar

  • Molecular model for a complete clathrin lattice from electron cryomicroscopy

    Alexander Fotin;Yifan Cheng;Piotr Sliz;Nikolaus Grigorieff

  • Phosphatidylinositol 4 Phosphate Regulates Targeting of Clathrin Adaptor AP-1 Complexes to the Golgi

    Ying Jie Wang;Jing Wang;Hui Qiao Sun;Manuel Martinez

  • Actin dynamics counteract membrane tension during clathrin-mediated endocytosis

    Steeve Boulant;Comert Kural;Comert Kural;Jean-Christophe Zeeh;Jean-Christophe Zeeh;Florent Ubelmann

  • Molecular Structure, Function, and Dynamics of Clathrin-Mediated Membrane Traffic

    Tom Kirchhausen;David Owen;Stephen C. Harrison

  • Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis.

    Tom Kirchhausen;Eric Macia;Eric Macia;Henry E. Pelish

  • Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms

    Tsung-Li Liu;Srigokul Upadhyayula;Daniel E. Milkie;Ved Vati Singh

  • Linking cargo to vesicle formation: receptor tail interactions with coat proteins

    Tomas Kirchhausen;Juan S Bonifacino;Howard Riezman

  • T-cell engagement of dendritic cells rapidly rearranges MHC class II transport

    Marianne Boes;Jan Cerny;Jan Cerny;Ramiro Massol;Marjolein Op den Brouw

  • An emergency response team for membrane repair.

    Paul L. McNeil;Tom Kirchhausen

  • Membrane fission by dynamin: what we know and what we need to know

    Bruno Antonny;Christopher G. Burd;Pietro de Camilli;Elizabeth H. Chen

  • Dileucine‐based sorting signals bind to the β chain of AP‐1 at a site distinct and regulated differently from the tyrosine‐based motif‐binding site

    Iris Rapoport;Yu Chen Chen;Philippe Cupers;Steven E. Shoelson

Frequent Co-Authors

Stephen C. Harrison
Stephen C. Harrison Harvard University
Steeve Boulant
Steeve Boulant University of Florida
Judy Lieberman
Judy Lieberman Boston Children's Hospital
Sean P. J. Whelan
Sean P. J. Whelan Washington University in St. Louis
Yifan Cheng
Yifan Cheng University of California, San Francisco
Thomas Walz
Thomas Walz Rockefeller University
Wayne I. Lencer
Wayne I. Lencer Harvard University
Nikolaus Grigorieff
Nikolaus Grigorieff Howard Hughes Medical Institute
Juan S. Bonifacino
Juan S. Bonifacino National Institutes of Health
Frederick W. Alt
Frederick W. Alt Boston Children's Hospital

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