Manuela Baccarini

What is she best known for?

The fields of study she is best known for:

• Gene
• Enzyme
• Apoptosis

Her scientific interests lie mostly in Kinase, Signal transduction, MAPK/ERK pathway, Proto-Oncogene Proteins c-raf and Cell biology. Her study looks at the intersection of Kinase and topics like Phosphorylation with Growth factor and JUNB. As a part of the same scientific family, Manuela Baccarini mostly works in the field of Signal transduction, focusing on Cancer research and, on occasion, Oncogene, Carcinogenesis, c-Raf, Effector and Gene silencing.

Her MAPK/ERK pathway study incorporates themes from Tumor necrosis factor alpha, Internal medicine and Endocrinology. The Proto-Oncogene Proteins c-raf study combines topics in areas such as Cell migration, Mitogen-activated protein kinase, Cell adhesion, Cytoskeleton and ASK1. Her Cell biology study integrates concerns from other disciplines, such as Tumor suppressor gene and Apoptosis, Cell cycle.

Her most cited work include:

• RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. (321 citations)
• Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock. (320 citations)
• Embryonic lethality and fetal liver apoptosis in mice lacking the c‐raf‐1 gene (262 citations)

What are the main themes of her work throughout her whole career to date?

Cell biology, MAPK/ERK pathway, Kinase, Signal transduction and Cancer research are her primary areas of study. Her Cell biology research focuses on subjects like Mutant, which are linked to In vitro. Her MAPK/ERK pathway research includes themes of Carcinogenesis, PI3K/AKT/mTOR pathway, Activator and In vivo.

Her Kinase research integrates issues from Apoptosis, Molecular biology and Gene isoform. Her research integrates issues of Embryonic stem cell, Regulation of gene expression, Cell cycle and Cell type in her study of Signal transduction. Her work in Cancer research tackles topics such as Immunology which are related to areas like Cellular differentiation.

She most often published in these fields:

• Cell biology (64.58%)
• MAPK/ERK pathway (50.00%)
• Kinase (41.67%)

What were the highlights of her more recent work (between 2012-2021)?

• MAPK/ERK pathway (50.00%)
• Cell biology (64.58%)
• Cancer research (20.83%)

In recent papers she was focusing on the following fields of study:

Manuela Baccarini mostly deals with MAPK/ERK pathway, Cell biology, Cancer research, Kinase and Carcinogenesis. Her MAPK/ERK pathway study is concerned with Signal transduction in general. Her research in Signal transduction intersects with topics in Tumor microenvironment and Protein kinase A.

Her work carried out in the field of Cell biology brings together such families of science as In vitro and Mutant. Her work deals with themes such as Apoptosis, Cancer, Immunology and Neuroblastoma RAS viral oncogene homolog, which intersect with Cancer research. She is interested in Proto-Oncogene Proteins c-raf, which is a branch of Kinase.

Between 2012 and 2021, her most popular works were:

• Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer (216 citations)
• MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral tolerance. (74 citations)
• "RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway. (66 citations)

In her most recent research, the most cited papers focused on:

• Gene
• Enzyme
• Apoptosis

Her primary areas of investigation include MAPK/ERK pathway, Cell biology, Signal transduction, Carcinogenesis and Cancer research. Her MAPK/ERK pathway research is multidisciplinary, incorporating elements of Protein phosphatase 2 and Protein kinase B. Manuela Baccarini is studying Stem cell, which is a component of Cell biology.

Her Signal transduction study combines topics from a wide range of disciplines, such as Tumor microenvironment, Kinase and Effector. Manuela Baccarini has included themes like Wound healing, Adult stem cell, Homeostasis and Keratinocyte in her Carcinogenesis study. Manuela Baccarini has researched Cancer research in several fields, including Apoptosis, PI3K/AKT/mTOR pathway and Protein kinase A.