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Overview

Arthur E. Jacobson is affiliated with the National Institutes of Health in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and neuroscience, with a strong focus on molecular biology and cellular and molecular neuroscience as subfields.

The primary topics explored in their work encompass neuropeptides and animal physiology, receptor mechanisms and signaling, pharmacological receptor mechanisms and effects, forensic toxicology and drug analysis, chemical synthesis and analysis, opioid use disorder treatment, and neurotransmitter receptor influence on behavior.

Frequent publication venues where their research appears include:

  • Molecules
  • Journal of Pharmacology and Experimental Therapeutics
  • Bioconjugate Chemistry
  • Vaccines
  • The Cambridge Structural Database

Frequent co-authors collaborating with Arthur E. Jacobson include:

  • Kenner C. Rice
  • Agnieszka Sulima
  • Gary R. Matyas
  • Thomas E. Prisinzano
  • Eric W. Bow

Selected recent research publications authored by Arthur E. Jacobson include:

  • Novel Vaccine That Blunts Fentanyl Effects and Sequesters Ultrapotent Fentanyl Analogues (2020, Molecular Pharmaceutics)
  • Bivalent Conjugate Vaccine Induces Dual Immunogenic Response That Attenuates Heroin and Fentanyl Effects in Mice (2021, Bioconjugate Chemistry)
  • Novel chimeric monoclonal antibodies that block fentanyl effects and alter fentanyl biodistribution in mice (2021, mAbs)
  • Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans (2023, Molecules)
  • G-Protein biased opioid agonists: 3-hydroxy-N-phenethyl-5-phenylmorphans with three-carbon chain substituents at C9 (2020, RSC Medicinal Chemistry)

Best Publications

  • STUDIES IN THE (+)-MORPHINAN SERIES. 5. SYNTHESIS AND BIOLOGICAL PROPERTIES OF (+)-NALOXONE

    I. Iijima;J. Minamikawa;A. E. Jacobson;A. Brossi

  • Interaction of endogenous opioid peptides and other drugs with four kappa opioid binding sites in guinea pig brain.

    Richard B Rothman;Victor Bykov;Brian R de Costa;Arthur E Jacobson

  • μ-, δ- and κ-opioid receptor-mediated inhibition of neurotransmitter release and adenylate cyclase activity in rat brain slices: studies with fentanyl isothiocyanate

    Anton N.M. Schoffelmeer;Kenner C. Rice;Arthur E. Jacobson;Johannus G. Van Gelderen

  • Opiate receptors in rat pituitary are confined to the neural lobe and are exclusively kappa.

    Miles Herkenham;Kenner C. Rice;Arthur E. Jacobson;Richard B. Rothman

  • Irreversible ligands with high selectivity toward delta and mu opiate receptors

    Kenner C. Rice;Arthur E. Jacobson;Terrence R. Burke;Balbir S. Bajwa

  • Synthesis and evaluation of optically pure [3H]-(+)-pentazocine, a highly potent and selective radioligand for σ receptors

    Brian R. de Costa;Wayne D. Bowen;Susan B. Hellewell;J.Michael Walker

  • Probes for Narcotic Receptor Mediated Phenomena

    Joannes T. M. Linders;Seid Mirsadeghi;Judith L. Flippen‐Anderson;Clifford George

  • Biological effects of modified colchicines. Improved preparation of 2-demethylcolchicine, 3-demethylcolchicine, and (+)-colchicine and reassignment of the position of the double bond in dehydro-7-deacetamidocolchicines.

    M Rösner;H G Capraro;A E Jacobson;L Atwell

  • Chronic administration of morphine and naltrexone up-regulate μ-opioid binding sites labeled by [3H][D-Ala2, MePhe4, Gly-ol5]enkephalin: further evidence for two μ-binding sites

    Richard B. Rothman;Victor Bykov;Joseph B. Long;Linda S. Brady

  • Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells.

    William F. Simonds;Terrence R. Burke;Kenner C. Rice;Arthur E. Jacobson

  • A quantitative study of [3H]D-Ala2-D-Leu5-enkephalin binding to rat brain membranes. Evidence that oxymorphone is a noncompetitive inhibitor of the lower affinity delta-binding site.

    R B Rothman;W D Bowen;M Herkenham;A E Jacobson

  • Ibogaine and its congeners are σ2 receptor-selective ligands with moderate affinity

    Wayne D. Bowen;Bertold J. Vilner;Wanda Williams;Craig M. Bertha

  • A specific acylating agent for the (3H)phencyclidine receptors in rat brain

    Michael F. Rafferty;Mariena Mattson;Arthur E. Jacobson;Kenner C. Rice

  • Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands.

    B R de Costa;W D Bowen;S B Hellewell;C George

  • Morphine tolerance increases μ-noncompetative δ binding sites

    Richard B. Rothman;Janine A. Danks;Arthur E. Jacobson;Terrence R. Burke

  • Identification of a Mr 58 000 glycoprotein subunit of the opiate receptor

    Werner A. Klee;William F. Simonds;Floyd W. Sweat;Terrence R. Burke

  • Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and dopamine to the dopamine transporter.

    Maarten E.A. Reith;Brian de Costa;Kenner C. Rice;Arthur E. Jacobson

  • Probes for narcotic receptor mediated phenomena. 7. Synthesis and pharmacological properties of irreversible ligands specific for mu or delta opiate receptors.

    Terrence R. Burke;Balbir S. Bajwa;Arthur E. Jacobson;Kenner C. Rice

  • Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists

    Brandon R. Selfridge;Xiaohui Wang;Yingning Zhang;Hang Yin

  • Upregulation of the opioid receptor complex by the chronic administration of morphine: a biochemical marker related to the development of tolerance and dependence

    Richard B. Rothman;Joseph B. Long;Victor Bykov;Heng Xu

Frequent Co-Authors

Kenner C. Rice
Kenner C. Rice National Institutes of Health
Terrence R. Burke
Terrence R. Burke National Institutes of Health
Jeffrey R. Deschamps
Jeffrey R. Deschamps United States Naval Research Laboratory
Carl R. Alving
Carl R. Alving Walter Reed Army Institute of Research
Judith L. Flippen-Anderson
Judith L. Flippen-Anderson United States Naval Research Laboratory
Clifford George
Clifford George United States Naval Research Laboratory
John E. Folk
John E. Folk National Institutes of Health
Daniel J. J. Carr
Daniel J. J. Carr University of Oklahoma Health Sciences Center
Candace B. Pert
Candace B. Pert National Institutes of Health
Jonathan L. Katz
Jonathan L. Katz National Institute on Drug Abuse

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