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Karel W. A. Wirtz

Karel W. A. Wirtz

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Biology and Biochemistry
Netherlands
2023

D-Index & Metrics

Chemistry

D-Index
71
Citations
17099
World Ranking
5590
National Ranking
132

Biology and Biochemistry

D-Index
71
Citations
17226
World Ranking
6681
National Ranking
172

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Biochemistry

The scientist’s investigation covers issues in Biochemistry, Phosphatidylcholine, Phospholipid, Phosphatidylinositol and Cell biology. Biochemistry is a component of his Sterol carrier protein, Membrane, Peroxisome, Vesicle and Microsome studies. Karel W. A. Wirtz interconnects Liposome and Sphingomyelin in the investigation of issues within Phosphatidylcholine.

His work deals with themes such as Chromatography and Cell membrane, which intersect with Phospholipid. His Phosphatidylinositol study combines topics in areas such as Phosphatidylinositol transfer protein, Protein phosphorylation and Metabolism. His research integrates issues of Oxidative stress, Lipid bilayer and Membrane protein in his study of Cell biology.

His most cited work include:

  • Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress (1244 citations)
  • Phospholipid transfer proteins. (395 citations)
  • Exchange of phospholipids between liver mitochondria and microsomes in vitro. (327 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include Biochemistry, Phosphatidylcholine, Phosphatidylinositol, Phospholipid and Phosphatidylinositol transfer protein. His Biochemistry study typically links adjacent topics like Molecular biology. His Phosphatidylcholine research includes themes of Vesicle, Chromatography and Liposome.

His biological study spans a wide range of topics, including Second messenger system, Isoelectric point, Metabolism and Inositol. His Phospholipid study integrates concerns from other disciplines, such as Microsome, Binding site and Biological membrane. The Phosphatidylinositol transfer protein study which covers Cell biology that intersects with Apoptosis and Membrane protein.

He most often published in these fields:

  • Biochemistry (62.90%)
  • Phosphatidylcholine (34.39%)
  • Phosphatidylinositol (27.60%)

What were the highlights of his more recent work (between 1999-2008)?

  • Biochemistry (62.90%)
  • Cell biology (17.19%)
  • Phosphatidylinositol transfer protein (20.81%)

In recent papers he was focusing on the following fields of study:

Karel W. A. Wirtz mainly focuses on Biochemistry, Cell biology, Phosphatidylinositol transfer protein, Molecular biology and Oxidative stress. His study in Biochemistry focuses on Peroxisome, Blot, Phosphatidylcholine, Plant lipid transfer proteins and Protein primary structure. His Cell biology research integrates issues from Phospholipid Binding, Apoptosis, Programmed cell death and Receptor.

His Phosphatidylinositol transfer protein research is multidisciplinary, incorporating elements of Phosphoinositide-dependent kinase-1, Chloroform, Phosphatidylinositol and Sphingomyelin. His Phosphatidylinositol study combines topics from a wide range of disciplines, such as Ethanol, Phospholipid, Phosphorylcholine and A-site, Binding site. His work in Oxidative stress tackles topics such as Reactive oxygen species which are related to areas like Photosensitizer, Biophysics, Mitochondrion, Necrosis and FOXO3.

Between 1999 and 2008, his most popular works were:

  • Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress (1244 citations)
  • “Wages of Fear”: transient threefold decrease in intracellular ATP level imposes apoptosis (130 citations)
  • Peroxisomes in human fibroblasts have a basic pH. (110 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Amino acid

His primary areas of study are Biochemistry, Cell biology, Oxidative stress, Reactive oxygen species and Peroxisome. Karel W. A. Wirtz performs integrative study on Biochemistry and Calnexin. His Cell biology study incorporates themes from Receptor, Phosphatidylinositol transfer protein, Phospholipid transfer protein and Lipoprotein.

Karel W. A. Wirtz interconnects Protein maturation, Antioxidant and Cytosol in the investigation of issues within Oxidative stress. His work deals with themes such as Superoxide dismutase, FOXO Family, FOXO4, Forkhead Box Protein O3 and Biophysics, which intersect with Reactive oxygen species. His biological study spans a wide range of topics, including Phospholipid, Membrane, Vesicle-associated membrane protein 8, Membrane protein and Protein Data Bank.

Best Publications

  • Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

    Geert J. P. L. Kops;Tobias B. Dansen;Paulien E. Polderman;Ingrid Saarloos

  • Phospholipid transfer proteins.

    K. W. A. Wirtz

  • Exchange of phospholipids between liver mitochondria and microsomes in vitro.

    K W A Wirtz;D B Zilversmit

  • Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.

    A. Moritz;P. N. E. De Graan;W. H. Gispen;K. W. A. Wirtz

  • Transfer of phospholipids between membrane

    K.W.A. Wirtz

  • Ratio-fluorescence microscopy of lipid oxidation in living cells using C11-BODIPY581/591

    E.H.W. Pap;G.P.C. Drummen;V.J. Winter;T.W.A. Kooij

  • Interaction of C-reactive protein with artificial phosphatidylcholine bilayers

    John E. Volanakis;Karel W. A. Wirtz

  • The human MDR3 P-glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice

    Alexander J. Smith;Johanna L.P.M. Timmermans-Hereijgers;Ben Roelofsen;Karel W.A. Wirtz

  • Corticotropin-(1--24)-tetracosapeptide affects protein phosphorylation and polyphosphoinositide metabolism in rat brain.

    Jellemer Jolles;Henk Zwiers;Ad Dekker;Karel W.A. Wirtz

  • Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function.

    Udo Seedorf;Martin Raabe;Peter Ellinghaus;Frank Kannenberg

  • Phospholipid Exchange between Membranes PURIFICATION OF BOVINE BRAIN PROTEINS THAT PREFERENTIALLY CATALYZE THE TRANSFER OF PHOSPHATIDYLINOSITOL

    George M. Helmkamp;Mark S. Harvey;Karel W.A. Wirtz;Laurens L.M. van Deenen

  • Some properties of phosphatidylcholine exchange protein purified from beef liver

    H.H. Kamp;K.W.A. Wirtz;L.L.M. Van Deenen

  • FRET microscopy demonstrates molecular association of non-specific lipid transfer protein (nsL-TP) with fatty acid oxidation enzymes in peroxisomes.

    Fred S. Wouters;Fred S. Wouters;Fred S. Wouters;Philippe I.H. Bastiaens;Karel W.A. Wirtz;Thomas M. Jovin

  • Phospholipid transfer proteins revisited.

    Karel. W. A Wirtz

  • A role for phosphatidylinositol transfer protein in secretory vesicle formation

    Masato Ohashi;Klaas Jan de Vries;Rainer Frank;Gerry Snoek

  • “Wages of Fear”: transient threefold decrease in intracellular ATP level imposes apoptosis

    Denis S Izyumov;Armine V Avetisyan;Olga Yu Pletjushkina;Dmitrii V Sakharov

  • Phosphatidylcholine Exchange Protein from Beef Liver

    H.H. Kamp;K.W.A. Wirtz

  • Modulation of brain polyphosphoinositide metabolism by ACTH-sensitive protein phosphorylation.

    J. Jolles;H. Zwiers;C. J. van Dongen;P. Schotman

  • Participation of soluble liver proteins in the exchange of membrane phospholipids

    K.W.A. Wirtz;D.B. Zilversmit

  • Production of reactive oxygen species in mitochondria of HeLa cells under oxidative stress.

    Boris V. Chernyak;Denis S. Izyumov;Konstantin G. Lyamzaev;Alina A. Pashkovskaya

  • Specificity of the phosphatidylcholine exchange protein from bovine liver.

    H. H. Kamp;K. W. A. Wirtz;P. R. Baer;A. J. Slotboom

Frequent Co-Authors

L.L.M. Van Deenen
L.L.M. Van Deenen Utrecht University
Pentti Somerharju
Pentti Somerharju University of Helsinki
Ben Roelofsen
Ben Roelofsen Utrecht University
Rudy A. Demel
Rudy A. Demel Utrecht University
Ronald J.A. Wanders
Ronald J.A. Wanders University of Amsterdam
Antonie J. W. G. Visser
Antonie J. W. G. Visser Wageningen University & Research
Philippe I. H. Bastiaens
Philippe I. H. Bastiaens Max Planck Society
Udo Seedorf
Udo Seedorf Universität Hamburg
Arie J. Verkleij
Arie J. Verkleij Utrecht University
Piet Gros
Piet Gros Utrecht University

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