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Karel W. A. Wirtz

Karel W. A. Wirtz

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Biology and Biochemistry
Netherlands
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
17226
World Ranking
6681
National Ranking
172

Chemistry

D-Index
71
Citations
17099
World Ranking
5590
National Ranking
132

Karel W. A. Wirtz publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Karel W. A. Wirtz sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 237 publications — 45th percentile

45% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

Karel W. A. Wirtz D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Karel W. A. Wirtz sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 71 D-Index — 70th percentile

70% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Biochemistry

The scientist’s investigation covers issues in Biochemistry, Phosphatidylcholine, Phospholipid, Phosphatidylinositol and Cell biology. Biochemistry is a component of his Sterol carrier protein, Membrane, Peroxisome, Vesicle and Microsome studies. Karel W. A. Wirtz interconnects Liposome and Sphingomyelin in the investigation of issues within Phosphatidylcholine.

His work deals with themes such as Chromatography and Cell membrane, which intersect with Phospholipid. His Phosphatidylinositol study combines topics in areas such as Phosphatidylinositol transfer protein, Protein phosphorylation and Metabolism. His research integrates issues of Oxidative stress, Lipid bilayer and Membrane protein in his study of Cell biology.

His most cited work include:

  • Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress (1244 citations)
  • Phospholipid transfer proteins. (395 citations)
  • Exchange of phospholipids between liver mitochondria and microsomes in vitro. (327 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include Biochemistry, Phosphatidylcholine, Phosphatidylinositol, Phospholipid and Phosphatidylinositol transfer protein. His Biochemistry study typically links adjacent topics like Molecular biology. His Phosphatidylcholine research includes themes of Vesicle, Chromatography and Liposome.

His biological study spans a wide range of topics, including Second messenger system, Isoelectric point, Metabolism and Inositol. His Phospholipid study integrates concerns from other disciplines, such as Microsome, Binding site and Biological membrane. The Phosphatidylinositol transfer protein study which covers Cell biology that intersects with Apoptosis and Membrane protein.

He most often published in these fields:

  • Biochemistry (62.90%)
  • Phosphatidylcholine (34.39%)
  • Phosphatidylinositol (27.60%)

What were the highlights of his more recent work (between 1999-2008)?

  • Biochemistry (62.90%)
  • Cell biology (17.19%)
  • Phosphatidylinositol transfer protein (20.81%)

In recent papers he was focusing on the following fields of study:

Karel W. A. Wirtz mainly focuses on Biochemistry, Cell biology, Phosphatidylinositol transfer protein, Molecular biology and Oxidative stress. His study in Biochemistry focuses on Peroxisome, Blot, Phosphatidylcholine, Plant lipid transfer proteins and Protein primary structure. His Cell biology research integrates issues from Phospholipid Binding, Apoptosis, Programmed cell death and Receptor.

His Phosphatidylinositol transfer protein research is multidisciplinary, incorporating elements of Phosphoinositide-dependent kinase-1, Chloroform, Phosphatidylinositol and Sphingomyelin. His Phosphatidylinositol study combines topics from a wide range of disciplines, such as Ethanol, Phospholipid, Phosphorylcholine and A-site, Binding site. His work in Oxidative stress tackles topics such as Reactive oxygen species which are related to areas like Photosensitizer, Biophysics, Mitochondrion, Necrosis and FOXO3.

Between 1999 and 2008, his most popular works were:

  • Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress (1244 citations)
  • “Wages of Fear”: transient threefold decrease in intracellular ATP level imposes apoptosis (130 citations)
  • Peroxisomes in human fibroblasts have a basic pH. (110 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Amino acid

His primary areas of study are Biochemistry, Cell biology, Oxidative stress, Reactive oxygen species and Peroxisome. Karel W. A. Wirtz performs integrative study on Biochemistry and Calnexin. His Cell biology study incorporates themes from Receptor, Phosphatidylinositol transfer protein, Phospholipid transfer protein and Lipoprotein.

Karel W. A. Wirtz interconnects Protein maturation, Antioxidant and Cytosol in the investigation of issues within Oxidative stress. His work deals with themes such as Superoxide dismutase, FOXO Family, FOXO4, Forkhead Box Protein O3 and Biophysics, which intersect with Reactive oxygen species. His biological study spans a wide range of topics, including Phospholipid, Membrane, Vesicle-associated membrane protein 8, Membrane protein and Protein Data Bank.

Best Publications

  • Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

    Geert J. P. L. Kops;Tobias B. Dansen;Paulien E. Polderman;Ingrid Saarloos

  • Phospholipid transfer proteins.

    K. W. A. Wirtz

  • Exchange of phospholipids between liver mitochondria and microsomes in vitro.

    K W A Wirtz;D B Zilversmit

  • Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.

    A. Moritz;P. N. E. De Graan;W. H. Gispen;K. W. A. Wirtz

  • Transfer of phospholipids between membrane

    K.W.A. Wirtz

  • Ratio-fluorescence microscopy of lipid oxidation in living cells using C11-BODIPY581/591

    E.H.W. Pap;G.P.C. Drummen;V.J. Winter;T.W.A. Kooij

  • Interaction of C-reactive protein with artificial phosphatidylcholine bilayers

    John E. Volanakis;Karel W. A. Wirtz

  • The human MDR3 P-glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice

    Alexander J. Smith;Johanna L.P.M. Timmermans-Hereijgers;Ben Roelofsen;Karel W.A. Wirtz

  • Corticotropin-(1--24)-tetracosapeptide affects protein phosphorylation and polyphosphoinositide metabolism in rat brain.

    Jellemer Jolles;Henk Zwiers;Ad Dekker;Karel W.A. Wirtz

  • Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function.

    Udo Seedorf;Martin Raabe;Peter Ellinghaus;Frank Kannenberg

  • Phospholipid Exchange between Membranes PURIFICATION OF BOVINE BRAIN PROTEINS THAT PREFERENTIALLY CATALYZE THE TRANSFER OF PHOSPHATIDYLINOSITOL

    George M. Helmkamp;Mark S. Harvey;Karel W.A. Wirtz;Laurens L.M. van Deenen

  • Some properties of phosphatidylcholine exchange protein purified from beef liver

    H.H. Kamp;K.W.A. Wirtz;L.L.M. Van Deenen

  • FRET microscopy demonstrates molecular association of non-specific lipid transfer protein (nsL-TP) with fatty acid oxidation enzymes in peroxisomes.

    Fred S. Wouters;Fred S. Wouters;Fred S. Wouters;Philippe I.H. Bastiaens;Karel W.A. Wirtz;Thomas M. Jovin

  • Phospholipid transfer proteins revisited.

    Karel. W. A Wirtz

  • A role for phosphatidylinositol transfer protein in secretory vesicle formation

    Masato Ohashi;Klaas Jan de Vries;Rainer Frank;Gerry Snoek

  • “Wages of Fear”: transient threefold decrease in intracellular ATP level imposes apoptosis

    Denis S Izyumov;Armine V Avetisyan;Olga Yu Pletjushkina;Dmitrii V Sakharov

  • Phosphatidylcholine Exchange Protein from Beef Liver

    H.H. Kamp;K.W.A. Wirtz

  • Modulation of brain polyphosphoinositide metabolism by ACTH-sensitive protein phosphorylation.

    J. Jolles;H. Zwiers;C. J. van Dongen;P. Schotman

  • Participation of soluble liver proteins in the exchange of membrane phospholipids

    K.W.A. Wirtz;D.B. Zilversmit

  • Production of reactive oxygen species in mitochondria of HeLa cells under oxidative stress.

    Boris V. Chernyak;Denis S. Izyumov;Konstantin G. Lyamzaev;Alina A. Pashkovskaya

  • Specificity of the phosphatidylcholine exchange protein from bovine liver.

    H. H. Kamp;K. W. A. Wirtz;P. R. Baer;A. J. Slotboom

Frequent Co-Authors

L.L.M. Van Deenen
L.L.M. Van Deenen Utrecht University
Pentti Somerharju
Pentti Somerharju University of Helsinki
Ben Roelofsen
Ben Roelofsen Utrecht University
Rudy A. Demel
Rudy A. Demel Utrecht University
Ronald J.A. Wanders
Ronald J.A. Wanders University of Amsterdam
Antonie J. W. G. Visser
Antonie J. W. G. Visser Wageningen University & Research
Philippe I. H. Bastiaens
Philippe I. H. Bastiaens Max Planck Society
Udo Seedorf
Udo Seedorf Universität Hamburg
Arie J. Verkleij
Arie J. Verkleij Utrecht University
Piet Gros
Piet Gros Utrecht University

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