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Biology and Biochemistry

D-Index
65
Citations
36132
World Ranking
8921
National Ranking
236

Overview

Piet Gros is affiliated with Utrecht University in Netherlands and conducts research primarily within the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Immunology, Molecular Biology, Radiology, Nuclear Medicine and Imaging, Materials Chemistry, and Immunology and Allergy.

The scientist's research topics cover a range of areas with notable focus on:

  • Monoclonal and Polyclonal Antibodies Research
  • Complement system in diseases
  • Protein Structure and Dynamics
  • Cell Adhesion Molecules Research
  • Enzyme Structure and Function
  • Blood groups and transfusion
  • Glycosylation and Glycoproteins Research

Recent publications by Piet Gros highlight structural and functional aspects of immune and protein systems. Selected papers include:

  • "Complement component C3: A structural perspective and potential therapeutic implications" (2022), published in Seminars in Immunology
  • "C1q binding to surface-bound IgG is stabilized by C1r 2 s 2 proteases" (2021), published in Proceedings of the National Academy of Sciences
  • "Cryo-electron microscopy structure and potential enzymatic function of human six-transmembrane epithelial antigen of the prostate 1 (STEAP1)" (2020), published in Journal of Biological Chemistry
  • "A method for intuitively extracting macromolecular dynamics from structural disorder" (2021), published in Nature Communications
  • "Improving sampling of crystallographic disorder in ensemble refinement" (2021), published in Acta Crystallographica Section D Structural Biology

Piet Gros frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Zenodo (CERN European Organization for Nuclear Research), Nature Communications, Proceedings of the National Academy of Sciences, and Journal of Biological Chemistry.

They have collaborated regularly with several researchers, including:

  • Nicholas M. Pearce
  • Wout Oosterheert
  • Viviana Neviani
  • Maartje Ruyken
  • Suzan H. M. Rooijakkers

Best Publications

  • Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

    A.T. Brünger;A.T. Brünger;P.D. Adams;G.M. Clore;W.L. DeLano

  • Complement is activated by IgG hexamers assembled at the cell surface.

    Christoph A. Diebolder;Christoph A. Diebolder;Frank J. Beurskens;Rob N. de Jong;Roman I. Koning

  • Structures of Glycoprotein Ibα and Its Complex with von Willebrand Factor A1 Domain

    Eric G. Huizinga;Shizuko Tsuji;Roland A. P. Romijn;Marion E. Schiphorst

  • Structures of complement component C3 provide insights into the function and evolution of immunity

    Bert J. C. Janssen;Eric G. Huizinga;Hans C. A. Raaijmakers;Anja Roos

  • The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

    Wim de Lau;Weng Chuan Peng;Piet Gros;Hans Clevers

  • Specific chemical and structural damage to proteins produced by synchrotron radiation.

    Martin Weik;Raimond B. G. Ravelli;Gitay Kryger;Sean McSweeney

  • Complement component C3 – The “Swiss Army Knife” of innate immunity and host defense

    Daniel Ricklin;Edimara S. Reis;Dimitrios C. Mastellos;Piet Gros

  • Adhesion mechanism of human beta(2)-glycoprotein I to phospholipids based on its crystal structure.

    Barend Bouma;Philip G. de Groot;Jean M.H. van den Elsen;Raimond B.G. Ravelli

  • Structure of the translocator domain of a bacterial autotransporter.

    Clasien J Oomen;Peter van Ulsen;Patrick Van Gelder;Maya Feijen

  • Structure of C3b reveals conformational changes that underlie complement activity.

    Bert J. C. Janssen;Agni Christodoulidou;Andrew McCarthy;John D. Lambris

  • Structure of complement fragment C3b-factor H and implications for host protection by complement regulators.

    Jin Wu;You-Qiang Wu;Daniel Ricklin;Bert J C Janssen

  • Complement driven by conformational changes.

    Piet Gros;Fin J. Milder;Bert J. C. Janssen

  • Crystal structure of the outer membrane protease OmpT from Escherichia coli suggests a novel catalytic site.

    Lucy Vandeputte‐Rutten;R.Arjen Kramer;Jan Kroon;Jan Kroon;Niek Dekker;Niek Dekker

  • Modelling dynamics in protein crystal structures by ensemble refinement

    B Tom Burnley;Pavel V Afonine;Paul D Adams;Paul D Adams;Piet Gros

  • Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.

    Federico Forneris;Daniel Ricklin;Jin Wu;Apostolia Tzekou

  • Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor

    Suzan H M Rooijakkers;Jin Wu;Maartje Ruyken;Robert van Domselaar

  • Structure of C8α-MACPF Reveals Mechanism of Membrane Attack in Complement Immune Defense

    Michael A. Hadders;Dennis X. Beringer;Piet Gros

  • Structural insights into the Slit-Robo complex

    Cecile Morlot;Nicole M. Thielens;Raimond B. G. Ravelli;Wieger Hemrika

  • Platelet adhesion to collagen: an update.

    J. J. Sixma;G. H. Van Zanten;E. G. Huizinga;R. M. Van Der Plas

  • Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5b6 and sC5b9

    Michael A. Hadders;Doryen Bubeck;Pietro Roversi;Svetlana Hakobyan

Frequent Co-Authors

John D. Lambris
John D. Lambris University of Pennsylvania
Abraham J. Koster
Abraham J. Koster Leiden University Medical Center
Daniel Ricklin
Daniel Ricklin University of Basel
Raimond B. G. Ravelli
Raimond B. G. Ravelli Maastricht University
Jan Tommassen
Jan Tommassen Utrecht University
Wim G. J. Hol
Wim G. J. Hol University of Washington
Paul D. Adams
Paul D. Adams Lawrence Berkeley National Laboratory
Maarten R. Egmond
Maarten R. Egmond Utrecht University
Paul W. H. I. Parren
Paul W. H. I. Parren Leiden University Medical Center
Martin Lutz
Martin Lutz Utrecht University

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