World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
46
Citations
10735
World Ranking
18854
National Ranking
7704

Overview

Thomas A. Owen is affiliated with Pfizer in the United States. Their research primarily spans the field of Medicine, with subfields including Oncology, Pharmacology, and Molecular Biology. The scientist's work engages several key topics, such as inflammatory mediators and NSAID effects, bone health and treatments, peptidase inhibition and analysis, and RNA interference and gene delivery.

The scientist has contributed to multiple peer-reviewed publications. Notable papers authored or co-authored by them include:

  • KMN-159, a novel EP4 receptor selective agonist, stimulates osteoblastic differentiation in cultured whole rat bone marrow, 2020, published in Gene
  • Abstract 2872 Enhancing transfection efficiency of primary cells through lipid nanoparticle-mediated delivery, 2025, published in Journal of Biological Chemistry

Thomas A. Owen frequently collaborates with several other researchers in their field. The most common co-authors include:

  • Aileen Ariosa
  • Chandni Patel
  • Shanqiao Wei
  • Chi S. Ho
  • Kaylah Birmingham

Their research has appeared in scientific venues such as Gene and Journal of Biological Chemistry, reflecting a focus on molecular and biochemical studies within their domains of expertise.

Best Publications

  • Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix

    Thomas A. Owen;Michael A. Aronow;Victoria Shalhoub;Leesa M. Barone

  • Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation.

    Gary S. Stein;Jane B. Lian;Thomas A. Owen

  • Factors that promote progressive development of the osteoblast phenotype in cultured fetal rat calvaria cells.

    Michael A. Aronow;Louis C. Gerstenfeld;Thomas A. Owen;Melissa S. Tassinari

  • Pleiotropic Effects of Vitamin D on Osteoblast Gene Expression Are Related to the Proliferative and Differentiated State of the Bone Cell Phenotype: Dependency upon Basal Levels of Gene Expression, Duration of Exposure, and Bone Matrix Competency in Normal Rat Osteoblast Cultures

    Thomas A. Owen;Michael S. Aronow;Leesa M. Barone;Brian Bettencourt

  • CLONING AND CHARACTERIZATION OF A NOVEL MEMBER OF THE TRANSFORMING GROWTH FACTOR-BETA /BONE MORPHOGENETIC PROTEIN FAMILY

    Vishwas M. Paralkar;Amy L. Vail;William A. Grasser;Thomas A. Brown

  • Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription

    T A Owen;R Bortell;S A Yocum;S L Smock

  • Expression of connective tissue growth factor in bone: its role in osteoblast proliferation and differentiation in vitro and bone formation in vivo

    Fayez F. Safadi;Jie Xu;Steven L. Smock;Reem A. Kanaan

  • An EP2 receptor-selective prostaglandin E2 agonist induces bone healing

    V.M. Paralkar;Fran Borovečki;H.Z. Ke;K.O. Cameron

  • Effects of CP-336,156, a new, nonsteroidal estrogen agonist/antagonist, on bone, serum cholesterol, uterus and body composition in rat models.

    Hua Zhu Ke;Vishwas M. Paralkar;William A. Grasser;D. Todd Crawford

  • Cloning and characterization of osteoactivin, a novel cDNA expressed in osteoblasts.

    Fayez. F. Safadi;Jie Xu;Steven L. Smock;Mario C. Rico

  • Expression of heat shock genes during differentiation of mammalian osteoblasts and promyelocytic leukemia cells.

    Abdul Rauf Shakoori;Annette M. Oberdorf;Thomas A. Owen;Lee A. Weber

  • Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis

    Leonard Buckbinder;David T. Crawford;Hong Qi;Hua Zhu Ke

  • Estrogen Receptor-α Is Developmentally Regulated during Osteoblast Differentiation and Contributes to Selective Responsiveness of Gene Expression

    Peter V. N. Bodine;Ruth A. Henderson;Jack Green;Michael A. Aronow

  • Osteoactivin, an anabolic factor that regulates osteoblast differentiation and function.

    Samir M. Abdelmagid;Mary F. Barbe;Mario C. Rico;Sibel Salihoglu

  • A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing.

    Mei Li;Hua Zhu Ke;Hong Qi;David R Healy

  • Connective tissue growth factor (CTGF) acts as a downstream mediator of TGF‐β1 to induce mesenchymal cell condensation

    Jason J. Song;Rulla Aswad;Reem A. Kanaan;Mario C. Rico

  • Tumor cells exhibit deregulation of the cell cycle histone gene promoter factor HiNF-D

    Joost Holthuis;Thomas A. Owen;Andre J. van Wijnen;Kenneth L. Wright

  • The Onset and Progression of Osteoblast Differentiation is Functionally Related to Cellular Proliferation

    Gary S. Stein;Jane B. Lian;Louis C. Gerstenfeld;Victoria Shalhoub

  • The role of connective tissue growth factor (CTGF/CCN2) in skeletogenesis.

    John A Arnott;Alex G Lambi;Christina M Mundy;Honey Hendesi

  • Phenotype suppression: a postulated molecular mechanism for mediating the relationship of proliferation and differentiation by Fos/Jun interactions at AP-1 sites in steroid responsive promoter elements of tissue-specific genes.

    Jane B. Lian;Gary S. Stein;Rita Bortell;Thomas A. Owen

Frequent Co-Authors

Gary S. Stein
Gary S. Stein University of Vermont
Jane B. Lian
Jane B. Lian University of Vermont
Janet L. Stein
Janet L. Stein University of Vermont
Joost C. M. Holthuis
Joost C. M. Holthuis Osnabrück University
Andre J. Van Wijnen
Andre J. Van Wijnen University of Connecticut Health Center
Webster S. S. Jee
Webster S. S. Jee University of Utah
Louis C. Gerstenfeld
Louis C. Gerstenfeld Boston University
Thomas A. Brown
Thomas A. Brown Lawrence Livermore National Laboratory
Bruno Calabretta
Bruno Calabretta Thomas Jefferson University
Scot A. Wolfe
Scot A. Wolfe University of Massachusetts Chan Medical School

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