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Giorgio Berton

Giorgio Berton

D-Index & Metrics

Biology and Biochemistry

D-Index
48
Citations
9163
World Ranking
18345
National Ranking
587

Overview

Giorgio Berton is affiliated with the University of Verona in Italy and conducts research primarily in the field of Medicine. Their work spans several specialized subfields including Pulmonary and Respiratory Medicine, Immunology and Allergy, Molecular Biology, and Hematology.

The focus of Berton's research includes key topics such as Cystic Fibrosis Research Advances, Neonatal Respiratory Health Research, Cell Adhesion Molecules Research, Biochemical and Structural Characterization, and Platelet Disorders and Treatments.

Berton has contributed to publications in venues such as UNC Libraries, with documented works including:

  • Phospholipase C-δ3 Is a Key Modulator of IL-8 Expression in Cystic Fibrosis Bronchial Epithelial Cells, 2020, UNC Libraries
  • Src-family kinases mediate an outside-in signal necessary for β2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin, 2020, UNC Libraries

Frequent collaborators in Berton's research include:

  • Valentino Bezzerri
  • Pio D'Adamo
  • Alessandro Rimessi
  • Carmen Lanzara
  • Sérgio Crovella

The research contributions cover molecular and cellular mechanisms relevant to respiratory diseases, particularly focusing on interactions at the biochemical level that influence inflammation and immune response in pulmonary contexts.

This profile reflects a research career oriented towards detailed exploration of cellular signaling pathways and adhesion processes critical in respiratory health and disease, with implications for understanding and potentially treating cystic fibrosis and related conditions.

Best Publications

  • Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin

    Elena Zenaro;Enrica Caterina Pietronigro;Vittorina Della Bianca;Gennj Piacentino

  • Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions.

    Clifford Lowell;L Fumagalli;G Berton

  • Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases.

    Attila Mócsai;Zoltán Jakus;Tibor Vántus;Giorgio Berton

  • Integrin signalling in neutrophils and macrophages.

    Giorgio Berton;Clifford A Lowell

  • CXCL1/Macrophage Inflammatory Protein-2-Induced Angiogenesis In Vivo Is Mediated by Neutrophil-Derived Vascular Endothelial Growth Factor-A

    Patrizia Scapini;Monica Morini;Cristina Tecchio;Simona Minghelli

  • Sulfatides trigger increase of cytosolic free calcium and enhanced expression of tumor necrosis factor-alpha and interleukin-8 mRNA in human neutrophils. Evidence for a role of L-selectin as a signaling molecule.

    Carlo Laudanna;Gabriela Constantin;P Baron;E Scarpini

  • Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck

    Attila Mócsai;Attila Mócsai;Erzsébet Ligeti;Clifford A. Lowell;Giorgio Berton

  • Src and Syk kinases: key regulators of phagocytic cell activation

    Giorgio Berton;Attila Mócsai;Clifford A. Lowell

  • Generation of signals activating neutrophil functions by leukocyte integrins: LFA-1 and gp150/95, but not CR3, are able to stimulate the respiratory burst of human neutrophils.

    G. Berton;Carlo Laudanna;Claudio Sorio;F. Rossi

  • Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr

    Clifford A. Lowell;Giorgio Berton

  • IL-8 production by human polymorphonuclear leukocytes. The chemoattractant formyl-methionyl-leucyl-phenylalanine induces the gene expression and release of IL-8 through a pertussis toxin-sensitive pathway.

    M A Cassatella;F Bazzoni;M Ceska;I Ferro

  • Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils.

    Giorgio Berton;Laura Fumagalli;Carlo Laudanna;Claudio Sorio

  • Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages.

    Patrick W. Suen;Dusko Ilic;Elena Caveggion;Giorgio Berton

  • Signaling by adhesion in human neutrophils: activation of the p72syk tyrosine kinase and formation of protein complexes containing p72syk and Src family kinases in neutrophils spreading over fibrinogen.

    S. R. Yan;M. Huang;Giorgio Berton

  • Integrin signal transduction in myeloid leukocytes.

    Clifford A. Lowell;Giorgio Berton

  • Gamma interferon is able to enhance the oxidative metabolism of human neutrophils.

    Giorgio Berton;Lucia Zeni;Marco A. Cassatella;Filippo Rossi

  • Soluble interleukin-2 receptors in the sera of patients with hairy cell leukemia: relationship with the effect of recombinant alpha-interferon therapy on clinical parameters and natural killer in vitro activity.

    M Chilosi;G Semenzato;G Cetto;A Ambrosetti

  • The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating β2 integrin affinity and valency in neutrophils, but are required for β2 integrin-mediated outside-in signaling involved in sustained adhesion

    Cinzia Giagulli;Linda Ottoboni;Elena Caveggion;Barbara Rossi

  • Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport.

    L De Franceschi;L Fumagalli;O Olivieri;R Corrocher

  • Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance

    Ilaria Iacobucci;Annalisa Lonetti;Francesca Messa;Daniela Cilloni

Frequent Co-Authors

Clifford A. Lowell
Clifford A. Lowell University of California, San Francisco
Marco A. Cassatella
Marco A. Cassatella University of Verona
Filippo Rossi
Filippo Rossi University of Verona
Attila Mócsai
Attila Mócsai Semmelweis University
Giovanni Martinelli
Giovanni Martinelli University of Bologna
Michele Baccarani
Michele Baccarani University of Bologna
Gabriela Constantin
Gabriela Constantin University of Verona
Luigi Chieco-Bianchi
Luigi Chieco-Bianchi University of Padua
Giuseppe Saglio
Giuseppe Saglio University of Turin
Paolo Gasparini
Paolo Gasparini University of Trieste

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