World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
8823
World Ranking
15252
National Ranking
279

Overview

Thorsten Hornemann is a researcher affiliated with the University Hospital of Zurich in Switzerland. Their scientific work spans biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology, cell biology, physiology, neurology, and epidemiology as key subfields.

The scientific topics that dominate their research include sphingolipid metabolism and signaling, endoplasmic reticulum stress and disease, lipid membrane structure and behavior, amyotrophic lateral sclerosis (ALS) research, liver disease diagnosis and treatment, hereditary neurological disorders, as well as diet and metabolism studies.

Recent papers authored or coauthored by Hornemann include:

  • Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis, 2021, Nature Medicine
  • A global lipid map defines a network essential for Zika virus replication, 2020, Nature Communications
  • Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain bases, 2020, Proceedings of the National Academy of Sciences
  • Intrahepatic Fat and Postprandial Glycemia Increase After Consumption of a Diet Enriched in Saturated Fat Compared With Free Sugars, 2020, Diabetes Care
  • SPTLC1 variants associated with ALS produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins, 2022, Journal of Clinical Investigation

Frequent coauthors in Hornemann's body of work include:

  • Museer A. Lone
  • Andreas J. Hülsmeier
  • Gergely Karsai
  • Maike F. Dohrn
  • Adam Majcher

Hornemann has published extensively in several scientific venues, with notable frequent contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Journal of Clinical Investigation
  • Brain
  • Zenodo (CERN European Organization for Nuclear Research)

Best Publications

  • Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol.

    Reijo Laaksonen;Kim Ekroos;Marko Sysi-Aho;Mika Hilvo

  • Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids.

    Anke Penno;Anke Penno;Mary M. Reilly;Henry Houlden;Matilde Laura

  • Some new aspects of creatine kinase (CK): compartmentation, structure, function and regulation for cellular and mitochondrial bioenergetics and physiology.

    Theo Wallimann;Max Dolder;Uwe Schlattner;Michael Eder

  • Oral l -serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1

    Kevin Garofalo;Anke Penno;Brian P. Schmidt;Ho-Joon Lee

  • The SPTLC3 Subunit of Serine Palmitoyltransferase Generates Short Chain Sphingoid Bases

    Thorsten Hornemann;Anke Penno;Markus F. Rütti;Daniela Ernst

  • Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I.

    Annelies Rotthier;Michaela Auer-Grumbach;Katrien Janssens;Jonathan Baets

  • Deoxysphingoid bases as plasma markers in Diabetes mellitus

    Mariana Bertea;Markus F Rütti;Alaa Othman;Jaqueline Marti-Jaun

  • Plasma deoxysphingolipids: a novel class of biomarkers for the metabolic syndrome?

    A. Othman;M. F. Rütti;D. Ernst;C. H. Saely

  • Deoxysphingolipids, Novel Biomarkers for Type 2 Diabetes, Are Cytotoxic for Insulin-Producing Cells

    Richard A. Zuellig;Thorsten Hornemann;Alaa Othman;Adrian B. Hehl

  • Muscle-type Creatine Kinase Interacts with Central Domains of the M-band Proteins Myomesin and M-protein

    Thorsten Hornemann;Stefan Kempa;Mirko Himmel;Katrin Hayeß

  • Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

    Thorsten Hornemann;Yu Wei;Arnold von Eckardstein

  • Overexpression of the Wild-Type SPT1 Subunit Lowers Desoxysphingolipid Levels and Rescues the Phenotype of HSAN1

    Florian S. Eichler;Thorsten Hornemann;Alex McCampbell;Dika Kuljis

  • Isoenzyme-Specific Interaction of Muscle-Type Creatine Kinase with the Sarcomeric M-Line Is Mediated by Nh2-Terminal Lysine Charge-Clamps

    Thorsten Hornemann;Martin Stolz;Theo Wallimann

  • Plasma levels of sphingosine-1-phosphate and apolipoprotein M in patients with monogenic disorders of HDL metabolism

    Ratna Karuna;Rebekka Park;Rebekka Park;Alaa Othman;Adriaan G. Holleboom

  • Creatine kinase: An enzyme with a central role in cellular energy metabolism

    Theo Wallimann;Max Dolder;Uwe Schlattner;Michael Eder

  • The Phosphocreatine Circuit: Molecular and Cellular Physiology of Creatine Kinases, Sensitivity to Free Radicals, and Enhancement by Creatine Supplementation

    Theo Wallimann;Malgorzata Tokarska‐Schlattner;Dietbert Neumann;Richard M. Epand

  • Genotype, phenotype and disease severity reflected by serum LysoGb3 levels in patients with Fabry disease.

    Albina Nowak;Thomas P. Mechtler;Thorsten Hornemann;Joanna Gawinecka

  • Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration

    Federica Storti;Katrin Klee;Vyara Todorova;Regula Steiner

  • DEGS1-associated aberrant sphingolipid metabolism impairs nervous system function in humans

    Gergely Karsai;Florian Kraft;Natja Haag;G. Christoph Korenke

  • Frequent genes in rare diseases: panel-based next generation sequencing to disclose causal mutations in hereditary neuropathies

    Maike F. Dohrn;Maike F. Dohrn;Nicola Glöckle;Lejla Mulahasanovic;Corina Heller

Frequent Co-Authors

Arnold von Eckardstein
Arnold von Eckardstein University of Zurich
Mary M. Reilly
Mary M. Reilly University College London
Giuseppe Lauria
Giuseppe Lauria University of Milan
Henry Houlden
Henry Houlden University College London
Thomas F. Lüscher
Thomas F. Lüscher University of Zurich
Robert H. Brown
Robert H. Brown University of Massachusetts Chan Medical School
Vincent Timmerman
Vincent Timmerman University of Antwerp
Bart N. Lambrecht
Bart N. Lambrecht Ghent University
Markus Stoffel
Markus Stoffel University of Geneva
Ulf Landmesser
Ulf Landmesser Charité - University Medicine Berlin

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring studies in Biology or Biochemistry opens doors to a broad range of flexible, in-demand career pathways in healthcare and related fields. Many students pursue additional qualifications online, which can lead to rewarding roles in nutrition, nursing, administration, or mental health care.

For those interested in the intersection of biology and human health, pursuing the best online registered dietitian programs can prepare graduates to become certified nutrition professionals. Alternatively, biology majors looking to enter nursing may choose an rn to bsn online degree to accelerate their career progression and expand clinical skills.

Specializing in healthcare management is also a compelling option. You can quickly advance your credentials through the fastest online master's in healthcare administration—an ideal path for those interested in leadership or policy roles. Similarly, the fastest pmhnp program provides a route for biology graduates to become advanced practice nurses specializing in mental health.

These online degree options give Biology and Biochemistry students practical ways to translate their scientific knowledge into impactful, thriving careers in the rapidly evolving health sector.

Best Scientists Citing Thorsten Hornemann

Trending Scientists