World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
12580
World Ranking
10891
National Ranking
4720

Overview

Melvyn P. Heyes was affiliated with the National Institutes of Health in the United States during their career. Their professional activities were primarily connected to this institution.

No recent papers, frequent co-authors, publication venues, or book publications were recorded for Melvyn P. Heyes in the available data.

The data did not specify main fields of study, subfields, or main topics related to their research work, and there is no information on awards received.

As Melvyn P. Heyes is noted as deceased, all references to their career and affiliations are presented in the past tense. Limited information restricts a detailed account of their scientific contributions or research focus.

Best Publications

  • Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.

    M. P. Heyes;K. Saito;J. S. Crowley;L. E. Davis

  • Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status.

    Melvyn P. Heyes;Bruce J. Brew;Alex Martin;Richard W. Price

  • Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid.

    M P Heyes;K Saito;S P Markey

  • Cerebrospinal fluid and serum markers of inflammation in autism.

    Andrew W. Zimmerman;Andrew W. Zimmerman;Harumi Jyonouchi;Anne M. Comi;Susan L. Connors

  • Scleroderma, fasciitis, and eosinophilia associated with the ingestion of tryptophan.

    Richard M. Silver;Melvyn P. Heyes;John C. Maize;Bonnie Quearry

  • Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types

    Melvyn P. Heyes;Cai Y. Chen;Eugene O. Major;Kuniaki Saito

  • Quantitation of human immunodeficiency virus, immune activation factors, and quinolinic acid in AIDS brains.

    C L Achim;M P Heyes;C A Wiley

  • A mechanism for increased quinolinic acid formation following acute systemic immune stimulation.

    Kuniaki Saito;Jeffrey S. Crowley;Sanford P. Markey;Melvyn P. Heyes

  • A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.

    Melvyn P. Heyes;Kuniaki Saito;Eugene O. Major;Sheldon Milstien

  • Mechanism of Delayed Increases in Kynurenine Pathway Metabolism in Damaged Brain Regions Following Transient Cerebral Ischemia

    Kuniaki Saito;Thaddeus S. Nowak;Sanford P. Markey;Melvyn P. Heyes

  • Mechanism of increases in l-kynurenine and quinolinic acid in renal insufficiency

    Kuniaki Saito;Suwako Fujigaki;Melvyn P. Heyes;Katsumi Shibata

  • Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques

    Melvyn P. Heyes;Kuniaki Saito;Andrew Lackner;Clayton A. Wiley

  • Neuroinvasion by simian immunodeficiency virus coincides with increased numbers of perivascular macrophages/microglia and intrathecal immune activation

    Joan H Lane;Vito G Sasseville;Mary O Smith;Peter Vogel

  • Inter-relationships between quinolinic acid, neuroactive kynurenines, neopterin and β2-microglobulin in cerebrospinal fluid and serum of HIV-1-infected patients

    Melvyn P. Heyes;Bruce J. Brew;Kuniaki Saito;Bonnie J. Quearry

  • Time course of cerebrospinal fluid responses to antiretroviral therapy: evidence for variable compartmentalization of infection.

    Silvija Staprans;Natalia Marlowe;David Glidden;Tatjana Novakovic-agopian

  • Quantification of quinolinic acid in rat brain, whole blood, and plasma by gas chromatography and negative chemical ionization mass spectrometry: effects of systemic L-tryptophan administration on brain and blood quinolinic acid concentrations.

    Melvyn P. Heyes;Sanford P. Markey

  • Glutamate is a mediator of neurotoxicity in secretions of activated HIV-1-infected macrophages.

    Z. G. Jiang;C. Piggee;M. P. Heyes;C. Murphy

  • Neuroactive kynurenines in Lyme borreliasis

    John J. Halperin;Melvyn P. Heyes

  • Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation.

    Kuniaki Saito;Thaddeus S. Nowak;Kazuhiko Suyama;Bonnie J. Quearry

  • Elevated cerebrospinal fluid quinolinic acid levels are associated with region-specific cerebral volume loss in HIV infection.

    M P Heyes;R J Ellis;L Ryan;M E Childers

Frequent Co-Authors

Kuniaki Saito
Kuniaki Saito Fujita Health University
Sheldon Milstien
Sheldon Milstien Virginia Commonwealth University
Richard W. Price
Richard W. Price University of California, San Francisco
Alex Martin
Alex Martin National Institutes of Health
Bruce J. Brew
Bruce J. Brew University of New South Wales
Patrick M. Kochanek
Patrick M. Kochanek University of Pittsburgh
Igor Grant
Igor Grant University of California, San Diego
Lee E. Eiden
Lee E. Eiden National Institutes of Health
Andrew W. Zimmerman
Andrew W. Zimmerman University of Massachusetts Chan Medical School
Philip A. Pizzo
Philip A. Pizzo Stanford University

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