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Medicine

D-Index
78
Citations
19522
World Ranking
18145
National Ranking
583

Overview

Kuniaki Saito is affiliated with Fujita Health University in Japan and has contributed extensively to research in medicine and biochemistry, genetics, and molecular biology. Their work focuses primarily on molecular biology and genetics, with additional interests in plant science, neurology, and cellular and molecular neuroscience.

The scientist's research covers critical topics including:

  • Glioma Diagnosis and Treatment
  • CRISPR and Genetic Engineering
  • Chromosomal and Genetic Variations
  • CNS Lymphoma Diagnosis and Treatment
  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • Animal Genetics and Reproduction

Some of the recent notable papers authored by Saito and collaborators include:

  • Large-Scale Transgenic Drosophila Resource Collections for Loss- and Gain-of-Function Studies, 2020, Genetics
  • Crystal structure of Drosophila Piwi, 2020, Nature Communications
  • TERT promoter mutation confers favorable prognosis regardless of 1p/19q status in adult diffuse gliomas with IDH1/2 mutations, 2020, Acta Neuropathologica Communications
  • Hamster PIWI proteins bind to piRNAs with stage-specific size variations during oocyte maturation, 2021, Nucleic Acids Research
  • Liquid biopsy of cerebrospinal fluid for MYD88 L265P mutation is useful for diagnosis of central nervous system lymphoma, 2021, Cancer Science

Saito frequently publishes in the following venues:

  • Neuro-Oncology Advances
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuro-Oncology
  • Genetics
  • Nature Communications

Close collaboration is evident with several researchers, including:

  • Motoo Nagane
  • Keiichi Kobayashi
  • Nobuyoshi Sasaki
  • Yoshiaki Shiokawa
  • Keita Miyoshi

Best Publications

  • Lack of Interleukin-1β Decreases the Severity of Atherosclerosis in ApoE-Deficient Mice

    Hirokazu Kirii;Tamikazu Niwa;Yasuhiro Yamada;Hisayasu Wada

  • Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.

    M. P. Heyes;K. Saito;J. S. Crowley;L. E. Davis

  • CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression

    Charles L. Raison;Robert Dantzer;Keith W. Kelley;Marcus A. Lawson

  • Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid.

    M P Heyes;K Saito;S P Markey

  • Disruption of tumor necrosis factor-α gene diminishes the development of atherosclerosis in ApoE-deficient mice

    Hirotoshi Ohta;Hisayasu Wada;Tamikazu Niwa;Hirokazu Kirii

  • Early increases in TNF-α, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain

    Kuniaki Saito;Kazuhiko Suyama;Keiji Nishida;Yoshitatsu Sei

  • Structure and function of Zucchini endoribonuclease in piRNA biogenesis

    Hiroshi Nishimasu;Hirotsugu Ishizu;Hirotsugu Ishizu;Kuniaki Saito;Satoshi Fukuhara

  • A microRNA regulatory mechanism of osteoblast differentiation.

    Hiroyuki Inose;Hiroki Ochi;Ayako Kimura;Koji Fujita

  • Lipopolysaccharide induction of indoleamine 2,3‐dioxygenase is mediated dominantly by an IFN‐γ‐independent mechanism

    Suwako Fujigaki;Kuniaki Saito;Kenji Sekikawa;Shigenobu Tone

  • CREB phosphorylation as a molecular marker of memory processing in the hippocampus for spatial learning.

    Makoto Mizuno;Kiyofumi Yamada;Naoya Maekawa;Kuniaki Saito

  • Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types

    Melvyn P. Heyes;Cai Y. Chen;Eugene O. Major;Kuniaki Saito

  • Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse

    K. Saito;S.P. Markey;M.P. Heyes

  • Improved myocardial ischemia/reperfusion injury in mice lacking tumor necrosis factor-α

    Naoya Maekawa;Hisayasu Wada;Tsugiyasu Kanda;Tamikazu Niwa

  • A mechanism for increased quinolinic acid formation following acute systemic immune stimulation.

    Kuniaki Saito;Jeffrey S. Crowley;Sanford P. Markey;Melvyn P. Heyes

  • A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.

    Melvyn P. Heyes;Kuniaki Saito;Eugene O. Major;Sheldon Milstien

  • Mechanism of Delayed Increases in Kynurenine Pathway Metabolism in Damaged Brain Regions Following Transient Cerebral Ischemia

    Kuniaki Saito;Thaddeus S. Nowak;Sanford P. Markey;Melvyn P. Heyes

  • Mechanism of increases in l-kynurenine and quinolinic acid in renal insufficiency

    Kuniaki Saito;Suwako Fujigaki;Melvyn P. Heyes;Katsumi Shibata

  • Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques

    Melvyn P. Heyes;Kuniaki Saito;Andrew Lackner;Clayton A. Wiley

  • l-Tryptophan-l-Kynurenine Pathway Metabolism Accelerated by Toxoplasma gondii Infection Is Abolished in Gamma Interferon-Gene-Deficient Mice: Cross-Regulation between Inducible Nitric Oxide Synthase and Indoleamine-2,3-Dioxygenase

    Suwako Fujigaki;Kuniaki Saito;Masao Takemura;Naoya Maekawa

  • Structural characterization of the human estrogen synthetase (aromatase) gene

    Nobuhiro Harada;Kazuyo Yamada;Kuniaki Saito;Naomi Kibe

Frequent Co-Authors

Toshitaka Nabeshima
Toshitaka Nabeshima Meijo University
Melvyn P. Heyes
Melvyn P. Heyes National Institutes of Health
Hisataka Moriwaki
Hisataka Moriwaki Gifu University
Hiroshi Fujita
Hiroshi Fujita Gifu University
Kate Saenko
Kate Saenko Boston University
Tatsuya Harada
Tatsuya Harada University of Tokyo
Stan Sclaroff
Stan Sclaroff Boston University
Kiyofumi Yamada
Kiyofumi Yamada Nagoya University
Yasuhiro Yamada
Yasuhiro Yamada University of Tokyo
Eun-Joo Shin
Eun-Joo Shin Kangwon National University

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