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Biology and Biochemistry

D-Index
57
Citations
11504
World Ranking
13851
National Ranking
5859

Overview

Gaya K. Amarasinghe is affiliated with Washington University in St. Louis in the United States. Their research primarily focuses on infectious diseases within the broader field of medicine, with specific emphasis on viral infections, immunology, and epidemiology.

The main fields of study and topics in their work include:

  • Medicine
  • Infectious Diseases
  • Epidemiology
  • Molecular Biology
  • Immunology
  • Radiology, Nuclear Medicine and Imaging

  • Viral Infections and Outbreaks Research
  • Viral Infections and Vectors
  • SARS-CoV-2 and COVID-19 Research
  • Monoclonal and Polyclonal Antibodies Research
  • Interferon and Immune Responses
  • Respiratory Viral Infections Research
  • Mosquito-borne Diseases and Control

Amarasinghe has contributed to a number of recent research papers, including the following notable publications:

  • Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2 (2020), published in Cell Host & Microbe
  • 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales (2020), published in Archives of Virology
  • Itaconate confers tolerance to late NLRP3 inflammasome activation (2021), published in Cell Reports
  • Real-world COVID-19 vaccine effectiveness against the Omicron BA.2 variant in a SARS-CoV-2 infection-naive population (2023), published in Nature Medicine
  • Comparison of the immunogenicity of BNT162b2 and CoronaVac COVID-19 vaccines in Hong Kong (2021), published in Respirology

The scientist collaborates frequently with several researchers in their field. Frequent co-authors include:

  • Daisy W. Leung
  • Christopher F. Basler
  • Chao Wu
  • Michael L. Gross
  • Shane Miersch

Their work is regularly published in journals such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • ACS Infectious Diseases
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • Cell Reports

Best Publications

  • Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

    Monika Bambouskova;Laurent Gorvel;Vicky Lampropoulou;Alexey Sergushichev

  • Taxonomy of the order Mononegavirales: update 2016

    Claudio L. Afonso;Gaya K. Amarasinghe;Krisztián Bányai;Yīmíng Bào

  • Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2.

    James Brett Case;Paul W Rothlauf;Rita E Chen;Zhuoming Liu

  • NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop SL2 of the psi-RNA packaging signal. Implications for genome recognition.

    Gaya K Amarasinghe;Roberto N De Guzman;Ryan B Turner;Kalola J Chancellor

  • Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway.

    Cathleen Holze;Chloé Michaudel;Claire Mackowiak;Darya A. Haas

  • Taxonomy of the order Mononegavirales: update 2018

    Gaya K. Amarasinghe;Nidia G. Aréchiga Ceballos;Ashley C. Banyard;Christopher F. Basler

  • Taxonomy of the order Mononegavirales: update 2019.

    Gaya K. Amarasinghe;María A. Ayllón;Yīmíng Bào;Christopher F. Basler

  • Taxonomy of the order Mononegavirales: update 2017

    Gaya K. Amarasinghe;Yīmíng Bào;Christopher F. Basler;Sina Bavari

  • 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

    Jens H. Kuhn;Scott Adkins;Daniela Alioto;Sergey V. Alkhovsky

  • Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus

    Ilhem Messaoudi;Gaya K. Amarasinghe;Christopher F. Basler

  • Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1.

    Wei Xu;Megan R. Edwards;Dominika M. Borek;Alicia R. Feagins

  • Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35

    Daisy W Leung;Kathleen C Prins;Dominika M Borek;Mina Farahbakhsh

  • Mutual Antagonism between the Ebola Virus VP35 Protein and the RIG-I Activator PACT Determines Infection Outcome

    Priya Luthra;Parameshwaran Ramanan;Parameshwaran Ramanan;Chad E. Mire;Carla Weisend

  • A Viral RNA Structural Element Alters Host Recognition of Nonself RNA

    Jennifer L. Hyde;Christina L. Gardner;Taishi Kimura;James P. White

  • Evasion of interferon responses by Ebola and Marburg viruses.

    Christopher F. Basler;Gaya K. Amarasinghe

  • Mutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea Pigs

    Kathleen C. Prins;Sebastien Delpeut;Daisy W. Leung;Olivier Reynard

  • Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1.

    Bingke Yu;Ilídio R.S. Martins;Ilídio R.S. Martins;Pilong Li;Gaya K. Amarasinghe

  • An intrinsically disordered peptide from ebola virus VP35 controls viral RNA synthesis by modulating nucleoprotein-RNA interactions

    Daisy W. Leung;Dominika Borek;Priya Luthra;Jennifer M. Binning

  • Structure of the Ebola VP35 interferon inhibitory domain

    D.W Leung;N.D Ginder;D.B Fulton;J Nix

  • Itaconate confers tolerance to late NLRP3 inflammasome activation

    Monika Bambouskova;Lucie Potuckova;Tomas Paulenda;Martina Kerndl

Frequent Co-Authors

Christopher F. Basler
Christopher F. Basler University of Georgia
Norbert Nowotny
Norbert Nowotny University of Veterinary Medicine Vienna
Michael L. Gross
Michael L. Gross Washington University in St. Louis
Elke Mühlberger
Elke Mühlberger Boston University
Alexander Bukreyev
Alexander Bukreyev The University of Texas Medical Branch at Galveston
John M. Dye
John M. Dye United States Army Medical Research Institute of Infectious Diseases
Jens H. Kuhn
Jens H. Kuhn National Institutes of Health
Janusz T. Paweska
Janusz T. Paweska National Health Laboratory Service
Kartik Chandran
Kartik Chandran Albert Einstein College of Medicine

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