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Molecular Biology

D-Index
64
Citations
15201
World Ranking
1737
National Ranking
138

Overview

J. Mark Skehel is affiliated with the MRC Laboratory of Molecular Biology in the United Kingdom. Their research primarily falls within the field of Biochemistry, Genetics and Molecular Biology, with a specific focus on Molecular Biology, Cell Biology, Oncology, Organic Chemistry, and Neurology as subfields.

The scientist's work encompasses several main topics including RNA modifications and cancer, RNA and protein synthesis mechanisms, ubiquitin and proteasome pathways, click chemistry and applications, peptidase inhibition and analysis, neurological diseases and metabolism, and RNA research and splicing.

Among recent publications are:

  • Human CNS barrier-forming organoids with cerebrospinal fluid production (2020, Science)
  • Structure of a human 48 S translational initiation complex (2020, Science)
  • Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork (2020, Molecular Cell)
  • ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation (2022, Molecular Cell)
  • Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes (2021, Nature Communications)

Frequent coauthors in the scientist's research collaborations include:

  • Sarah Maslen
  • Sew-Yeu Peak-Chew
  • Helen R. Flynn
  • Ambrosius P. Snijders
  • Chloë Roustan

J. Mark Skehel's work has appeared in a range of publication venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cell
  • Nature Communications
  • eLife
  • Science

Best Publications

  • Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

    John C. Clapham;Jonathan R. S. Arch;Helen Chapman;Andrea Haynes

  • Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.

    Glenn R. Masson;John E. Burke;Natalie G. Ahn;Ganesh S. Anand

  • Eco1-Dependent Cohesin Acetylation During Establishment of Sister Chromatid Cohesion

    Tom Rolef Ben-Shahar;Sebastian Heeger;Chris Lehane;Philip East

  • Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.

    Dragana Ahel;Zuzana Hořejší;Nicola Wiechens;Sophie E. Polo

  • Bovine complex I is a complex of 45 different subunits.

    Joe Carroll;Ian M. Fearnley;J. Mark Skehel;Richard J. Shannon

  • Identification of Holliday junction resolvases from humans and yeast

    Stephen C. Y. Ip;Ulrich Rass;Miguel G. Blanco;Helen R. Flynn

  • F-Actin Is an Evolutionarily Conserved Damage-Associated Molecular Pattern Recognized by DNGR-1, a Receptor for Dead Cells

    Susan Ahrens;Santiago Zelenay;David Sancho;Pavel Hanč

  • Greatwall Phosphorylates an Inhibitor of Protein Phosphatase 2Α That Is Essential for Mitosis

    Satoru Mochida;Sarah L. Maslen;Mark Skehel;Tim Hunt

  • Mechanism of parkin activation by PINK1

    Christina Gladkova;Sarah L. Maslen;J. Mark Skehel;David Komander

  • Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis

    Joao Matos;Miguel G. Blanco;Sarah Maslen;J. Mark Skehel

  • MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.

    Kerstin Gari;Ana María León Ortiz;Valérie Borel;Helen Flynn

  • Sequences of 20 subunits of NADH : ubiquinone oxidoreductase from bovine heart mitochondria : application of a novel strategy for sequencing proteins using the polymerase chain reaction

    Walker Je;Arizmendi Jm;Dupuis A;Fearnley Im

  • Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN

    Julian Stingele;Roberto Bellelli;Ferdinand Alte;Graeme Hewitt

  • FANCM and FAAP24 Function in ATR-Mediated Checkpoint Signaling Independently of the Fanconi Anemia Core Complex

    Spencer J Collis;Alberto Ciccia;Alberto Ciccia;Andrew J Deans;Zuzana Horejsí

  • F0 Membrane Domain of ATP Synthase from Bovine Heart Mitochondria: Purification, Subunit Composition, and Reconstitution with F1-ATPase

    Collinson Ir;Runswick Mj;Buchanan Sk;Fearnley Im

  • CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.

    Zuzana Hořejší;Hiroyuki Takai;Carrie A. Adelman;Spencer J. Collis;Spencer J. Collis

  • Molecular basis of APC/C regulation by the spindle assembly checkpoint

    Claudio Alfieri;Leifu Chang;Ziguo Zhang;Jing Yang

  • Molecular mechanism of APC/C activation by mitotic phosphorylation

    Suyang Zhang;Leifu Chang;Claudio Alfieri;Zhiguo Zhang

  • Relationship between mitochondrial NADH-ubiquinone reductase and a bacterial NAD-reducing hydrogenase

    S. J. Pilkington;J. M. Skehel;R. B. Gennis;J. E. Walker

  • Presence of an acyl carrier protein in NADH:ubiquinone oxidoreductase from bovine heart mitochondria.

    Michael J. Runswick;Ian M. Fearnley;J.Mark Skehel;John E. Walker

Frequent Co-Authors

Simon J. Boulton
Simon J. Boulton The Francis Crick Institute
John E. Walker
John E. Walker University of Cambridge
Ian M. Fearnley
Ian M. Fearnley University of Cambridge
Michael J. Runswick
Michael J. Runswick Medical Research Council
Laurence H. Pearl
Laurence H. Pearl University of Sussex
Chrisostomos Prodromou
Chrisostomos Prodromou University of Sussex
Oscar Llorca
Oscar Llorca Spanish National Research Council
Peter Cherepanov
Peter Cherepanov The Francis Crick Institute
Stephen C. West
Stephen C. West The Francis Crick Institute
Grant S. Stewart
Grant S. Stewart University of Birmingham

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