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Chemistry

D-Index
68
Citations
18391
World Ranking
6454
National Ranking
373

Research.com Recognitions

  • 2018 - Interdisciplinary Prize, Royal Society of Chemistry (UK)
  • 2018 - Fellow of the Royal Society, United Kingdom

Overview

Judy Hirst is affiliated with the University of Cambridge in the United Kingdom. Their research primarily focuses on biochemistry, genetics, and molecular biology, contributing to subfields such as molecular biology, structural biology, spectroscopy, biophysics, and renewable energy, sustainability, and the environment.

The scientific work covers a range of topics including mitochondrial function and pathology, ATP synthase and ATPases research, photosynthetic processes and mechanisms, advanced electron microscopy techniques and applications, RNA and protein synthesis mechanisms, protein structure and dynamics, and genomics and phylogenetic studies.

Recent publications by Judy Hirst include:

  • Structural basis for a complex I mutation that blocks pathological ROS production, 2021, Nature Communications
  • Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation, 2020, Nature Structural & Molecular Biology
  • Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides, 2023, Science
  • Structure of inhibitor-bound mammalian complex I, 2020, Nature Communications
  • Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy, 2022, Nature Communications

Frequently collaborating co-authors include:

  • Injae Chung
  • Hannah R. Bridges
  • Zhan Yin
  • Daniel N. Grba
  • John J. Wright

Judy Hirst publishes frequently in venues such as EMPIAR dataset, bioRxiv (Cold Spring Harbor Laboratory), Biochimica et Biophysica Acta (BBA) - Bioenergetics, Nature Communications, and Science Advances.

Throughout their career, Judy Hirst has received recognition including the Fellow of the Royal Society, United Kingdom (2018) and the Interdisciplinary Prize from the Royal Society of Chemistry (UK) (2018).

Best Publications

  • An inhibitor of oxidative phosphorylation exploits cancer vulnerability.

    Jennifer R. Molina;Yuting Sun;Marina Protopopova;Sonal Gera

  • The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria

    Lothar Kussmaul;Judy Hirst

  • Mitochondrial complex I.

    Judy Hirst

  • Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria.

    Hannah R. Bridges;Andrew J. Y. Jones;Michael N. Pollak;Judy Hirst

  • Reversible interconversion of carbon dioxide and formate by an electroactive enzyme.

    Torsten Reda;Caroline M. Plugge;Nerilie J. Abram;Judy Hirst

  • Structure of mammalian respiratory complex I

    Jiapeng Zhu;Kutti R. Vinothkumar;Judy Hirst

  • Bovine complex I is a complex of 45 different subunits.

    Joe Carroll;Ian M. Fearnley;J. Mark Skehel;Richard J. Shannon

  • Reaction of complex metalloproteins studied by protein-film voltammetry

    Fraser A. Armstrong;Hendrik A. Heering;Judy Hirst

  • Reversible glutathionylation of complex I increases mitochondrial superoxide formation

    Ellen R. Taylor;Fiona Hurrell;Richard J. Shannon;Tsu-Kung Lin

  • The nuclear encoded subunits of complex I from bovine heart mitochondria.

    Judy Hirst;Joe Carroll;Ian M. Fearnley;Richard J. Shannon

  • Architecture of mammalian respiratory complex I

    Kutti R. Vinothkumar;Jiapeng Zhu;Judy Hirst

  • Analysis of the Subunit Composition of Complex I from Bovine Heart Mitochondria

    Joe Carroll;Ian M. Fearnley;Richard J. Shannon;Judy Hirst

  • The production of reactive oxygen species by complex I.

    Judy Hirst;Martin S. King;Kenneth R. Pryde

  • Reversibility and efficiency in electrocatalytic energy conversion and lessons from enzymes

    Fraser A. Armstrong;Judy Hirst

  • The Enigma of the Respiratory Chain Supercomplex

    Dusanka Milenkovic;James N. Blaza;Nils-Göran Larsson;Nils-Göran Larsson;Judy Hirst

  • Superoxide Is Produced by the Reduced Flavin in Mitochondrial Complex I A SINGLE, UNIFIED MECHANISM THAT APPLIES DURING BOTH FORWARD AND REVERSE ELECTRON TRANSFER

    Kenneth R. Pryde;Judy Hirst

  • Interaction of the Mitochondria-targeted Antioxidant MitoQ with Phospholipid Bilayers and Ubiquinone Oxidoreductases

    Andrew M. James;Mark S. Sharpley;Abdul-Rahman B. Manas;Frank E. Frerman

  • GRIM-19, a Cell Death Regulatory Gene Product, Is a Subunit of Bovine Mitochondrial NADH:Ubiquinone Oxidoreductase (Complex I)

    Ian M. Fearnley;Joe Carroll;Richard J. Shannon;Michael J. Runswick

  • Reversible Interconversion of CO2 and Formate by a Molybdenum-Containing Formate Dehydrogenase

    Arnau Bassegoda;Christopher Madden;David W. Wakerley;Erwin Reisner

  • Fast-scan cyclic voltammetry of protein films on pyrolytic graphite edge electrodes: characteristics of electron exchange.

    Judy Hirst;Fraser A. Armstrong

  • Interactions between Phospholipids and NADH:Ubiquinone Oxidoreductase (Complex I) from Bovine Mitochondria†

    Mark S Sharpley;Richard J Shannon;Federica Draghi;Judy Hirst

Frequent Co-Authors

Fraser A. Armstrong
Fraser A. Armstrong University of Oxford
John E. Walker
John E. Walker University of Cambridge
Ian M. Fearnley
Ian M. Fearnley University of Cambridge
Erwin Reisner
Erwin Reisner University of Cambridge
James A. Fee
James A. Fee Scripps Research Institute
Michael P. Murphy
Michael P. Murphy University of Cambridge
Ville R. I. Kaila
Ville R. I. Kaila Stockholm University
Guy N. L. Jameson
Guy N. L. Jameson University of Melbourne
Richard G. Compton
Richard G. Compton University of Oxford
Peter R. Rich
Peter R. Rich University College London

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