World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
53
Citations
11167
World Ranking
12994
National Ranking
733

Biology and Biochemistry

D-Index
54
Citations
11390
World Ranking
15558
National Ranking
1224

Overview

David N. Bolam is a researcher affiliated with Newcastle University in the United Kingdom. Their work is primarily situated within the broad field of Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology, Nutrition and Dietetics, Biotechnology, Organic Chemistry, and Food Science.

Their research centers on topics including Glycosylation and Glycoproteins Research, Gut microbiota and health, Microbial Metabolites in Food Biotechnology, Carbohydrate Chemistry and Synthesis, Enzyme Production and Characterization, Probiotics and Fermented Foods, and Genomics and Phylogenetic Studies.

David N. Bolam has contributed to numerous scientific publications, some of the most recent being:

  • Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown, 2020, Nature Communications
  • Insights into SusCD-mediated glycan import by a prominent gut symbiont, 2021, Nature Communications
  • Diverse events have transferred genes for edible seaweed digestion from marine to human gut bacteria, 2022, Cell Host & Microbe
  • Cryptic diversity of cellulose-degrading gut bacteria in industrialized humans, 2024, Science
  • Outer membrane utilisomes mediate glycan uptake in gut Bacteroidetes, 2023, Nature

The venues where David N. Bolam frequently publishes include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • Microbiology
  • Cell Host & Microbe

Collaborations form an integral component of their work, with regular coauthors including Lucy I. Crouch, Arnaud Baslé, Paulina A. Urbanowicz, Daniel I. R. Spencer, and Eric C. Martens.

Best Publications

  • Carbohydrate-binding modules: fine-tuning polysaccharide recognition

    Alisdair B. Boraston;David N. Bolam;Harry J. Gilbert;Gideon J. Davies

  • Recognition and degradation of plant cell wall polysaccharides by two human gut symbionts.

    Eric C. Martens;Eric C. Martens;Elisabeth C. Lowe;Herbert Chiang;Nicholas A. Pudlo

  • Specificity of Polysaccharide Use in Intestinal Bacteroides Species Determines Diet-Induced Microbiota Alterations

    Erica D. Sonnenburg;Hongjun Zheng;Payal Joglekar;Steven K. Higginbottom

  • Glycan complexity dictates microbial resource allocation in the large intestine

    Artur Rogowski;Jonathon A. Briggs;Jennifer C. Mortimer;Theodora Tryfona

  • Pseudomonas cellulose-binding domains mediate their effects by increasing enzyme substrate proximity

    David N. Bolam;Antonio Ciruela;Simon McQUEEN-MASON;Peter Simpson

  • The pattern of xylan acetylation suggests xylan may interact with cellulose microfibrils as a twofold helical screw in the secondary plant cell wall of Arabidopsis thaliana

    Marta Busse‐Wicher;Thiago C. F. Gomes;Theodora Tryfona;Nino Nikolovski

  • Understanding the Biological Rationale for the Diversity of Cellulose-directed Carbohydrate-binding Modules in Prokaryotic Enzymes

    Anthony W. Blake;Lesley McCartney;James E. Flint;David N. Bolam

  • Structural basis for nutrient acquisition by dominant members of the human gut microbiota.

    Amy J. Glenwright;Karunakar R. Pothula;Satya P. Bhamidimarri;Dror S. Chorev

  • The Structural Basis for the Ligand Specificity of Family 2 Carbohydrate-binding Modules

    Peter J. Simpson;Hefang Xie;David N. Bolam;Harry J. Gilbert

  • The X6 "thermostabilizing" domains of xylanases are carbohydrate-binding modules: structure and biochemistry of the Clostridium thermocellum X6b domain.

    Simon J. Charnock;David N. Bolam;Johan P. Turkenburg;Harry J. Gilbert

  • The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity

    David N. Bolam;Shirley Roberts;Mark R. Proctor;Johan P. Turkenburg

  • Complex N -glycan breakdown by gut Bacteroides involves an extensive enzymatic apparatus encoded by multiple co-regulated genetic loci

    Justina Briliūtė;Paulina A. Urbanowicz;Ana S. Luis;Arnaud Baslé

  • Differential recognition of plant cell walls by microbial xylan-specific carbohydrate-binding modules

    Lesley McCartney;Anthony W. Blake;James Flint;David N. Bolam

  • Glycoside hydrolase carbohydrate-binding modules as molecular probes for the analysis of plant cell wall polymers.

    Lesley McCartney;Harry J Gilbert;David N Bolam;Alisdair B Boraston

  • How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans

    Alan Cartmell;Elisabeth C. Lowe;Arnaud Baslé;Susan J. Firbank

  • Insights into the Synthesis of Lipopolysaccharide and Antibiotics through the Structures of Two Retaining Glycosyltransferases from Family GT4

    Carlos Martinez-Fleites;Mark Proctor;Shirley Roberts;David N. Bolam

  • Xyloglucan Is Recognized by Carbohydrate-binding Modules That Interact with β-Glucan Chains

    Shabir Najmudin;Catarina I. P. D. Guerreiro;Ana L. Carvalho;José A. M. Prates

  • Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown

    Lucy I. Crouch;Lucy I. Crouch;Marcelo V. Liberato;Paulina A. Urbanowicz;Arnaud Baslé

  • The location of the ligand-binding site of carbohydrate-binding modules that have evolved from a common sequence is not conserved.

    Mirjam Czjzek;David N. Bolam;Amor Mosbah;Julie Allouch

  • Crystal structure of mannanase 26A from Pseudomonas cellulosa and analysis of residues involved in substrate binding.

    Deborah Hogg;Eui-Jeon Woo;David N. Bolam;Vincent A. McKie

  • A novel carbohydrate-binding protein is a component of the plant cell wall-degrading complex of Piromyces equi.

    Alexander C.J. Freelove;David N. Bolam;Peter White;Geoffrey P. Hazlewood

Frequent Co-Authors

Harry J. Gilbert
Harry J. Gilbert Newcastle University
Gideon J. Davies
Gideon J. Davies University of York
Michael P. Williamson
Michael P. Williamson University of Sheffield
Carlos M. G. A. Fontes
Carlos M. G. A. Fontes Nzytech (Portugal)
Bernard Henrissat
Bernard Henrissat Technical University of Denmark
Mirjam Czjzek
Mirjam Czjzek Sorbonne University
Alisdair B. Boraston
Alisdair B. Boraston University of Victoria
José A. M. Prates
José A. M. Prates University of Lisbon
Eric C. Martens
Eric C. Martens University of Michigan–Ann Arbor
Carol V. Robinson
Carol V. Robinson University of Oxford

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