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Jan Kihlberg

Jan Kihlberg

D-Index & Metrics

Chemistry

D-Index
62
Citations
13475
World Ranking
8842
National Ranking
121

Overview

Jan Kihlberg is affiliated with Uppsala University in Sweden and has an extensive research portfolio primarily in the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus on Medicine.

Their research covers several subfields including Molecular Biology, Computational Theory and Mathematics, Radiology, Nuclear Medicine and Imaging, Immunology, and Rheumatology. The main topics of their work emphasize chemical synthesis and analysis, computational drug discovery methods, monoclonal and polyclonal antibodies research, protein degradation and inhibitors, receptor mechanisms and signaling, ubiquitin and proteasome pathways, and peptidase inhibition and analysis.

Kihlberg has published consistently in notable scientific journals. The most frequent publication venues are:

  • Journal of Medicinal Chemistry
  • Zenodo (CERN European Organization for Nuclear Research)
  • ACS Medicinal Chemistry Letters
  • Chemistry - A European Journal
  • Annals of the Rheumatic Diseases

Selected recent papers by Jan Kihlberg include:

  • Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses, 2022, Journal of the American Chemical Society
  • Macrocycles in Drug DiscoveryLearning from the Past for the Future, 2023, Journal of Medicinal Chemistry
  • Solution Conformations Shed Light on PROTAC Cell Permeability, 2020, ACS Medicinal Chemistry Letters
  • Enhancing preclinical drug discovery with artificial intelligence, 2021, Drug Discovery Today
  • Solution Conformations Explain the Chameleonic Behaviour of Macrocyclic Drugs, 2020, Chemistry - A European Journal

Frequent co-authors who have collaborated with Kihlberg in numerous publications include:

  • Vasanthanathan Poongavanam
  • Jens Carlsson
  • Máté Erdélyi
  • Duc Duy Vo
  • Yoseph Atilaw

Best Publications

  • Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates

    Bradley Croy Doak;Bjӧrn Over;Fabrizio Giordanetto;Jan Kihlberg

  • Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?

    Fabrizio Giordanetto;Jan Kihlberg

  • 2-(Trimethylsilyl)ethyl glycosides. 3. Synthesis, anomeric deblocking, and transformation into 1,2-trans 1-O-acyl sugars

    Karl Jansson;Stefan Ahlfors;Torbjoern Frejd;Jan Kihlberg

  • Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

    Unknown

  • How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets

    Bradley C. Doak;Jie Zheng;Doreen Dobritzsch;Jan Kihlberg

  • Structural basis of pilus subunit recognition by the PapD chaperone.

    Meta J. Kuehn;Derek J. Ogg;Jan Kihlberg;Lynn N. Slonim

  • Cell permeability beyond the rule of 5

    Pär Matsson;Bradley C. Doak;Björn Over;Jan Kihlberg

  • How Big Is Too Big for Cell Permeability

    Pär Matsson;Jan Kihlberg

  • Role of the Human ST6GalNAc-I and ST6GalNAc-II in the Synthesis of the Cancer-Associated Sialyl-Tn Antigen

    Nuno T. Marcos;Sandra Pinho;Catarina Grandela;Andrea Cruz

  • Macrocycles in Drug Discovery—Learning from the Past for the Future

    Unknown

  • Predominant selection of T cells specific for the glycosylated collagen type II epitope (263–270) in humanized transgenic mice and in rheumatoid arthritis

    Johan Bäcklund;Stefan Carlsen;Torsten Höger;Björn Holm

  • The PapG adhesin of uropathogenic Escherichia coli contains separate regions for receptor binding and for the incorporation into the pilus.

    Scott J. Hultgren;Frederik Lindberg;Goran Magnusson;Jan Kihlberg

  • Epitope glycosylation plays a critical role for T cell recognition of type II collagen in collagen‐induced arthritis

    Alexandre Corthay;Johan Bäcklund;Johan Broddefalk;Erik Michaelsson

  • Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5.

    Matteo Rossi Sebastiano;Bradley C. Doak;Maria Backlund;Vasanthanathan Poongavanam

  • Structural and conformational determinants of macrocycle cell permeability

    Björn Over;Pär Matsson;Pär Matsson;Christian Tyrchan;Per Artursson;Per Artursson

  • The in situ activation of thioglycosides with bromine: an improved glycosylation method

    Jan O. Kihlberg;David A. Leigh;David R. Bundle

  • The sesquiterpenes of Lactarius vellereus and their role in a proposed chemical defense system.

    Olov Sterner;Rolf Bergman;Jan Kihlberg;Börje Wickberg

  • Design and evaluation of pilicides: potential novel antibacterial agents directed against uropathogenic Escherichia coli.

    Anette Svensson;Andreas Larsson;Hans Emtenäs;Mattias Hedenström

  • Solution Conformations Shed Light on PROTAC Cell Permeability.

    Yoseph Atilaw;Vasanthanathan Poongavanam;Caroline Svensson Nilsson;Duy Nguyen

  • Glycosylation of type II collagen is of major importance for T cell tolerance and pathology in collagen-induced arthritis

    Johan Bäcklund;Alexandra Treschow;Robert Bockermann;Björn Holm

  • Glycosylated peptide hormones: pharmacological properties and conformational studies of analogues of [1-desamino,8-D-arginine]vasopressin.

    Jan Kihlberg;Jens Aahman;Bjoern Walse;Torbjoern Drakenberg

  • Glycopeptides bind MHC molecules and elicit specific T cell responses.

    Clifford V Harding;Jan Kihlberg;Mikael Elofsson;Göran Magnusson

  • Preparation of building blocks for glycopeptide synthesis by glycosylation of Fmoc amino acids having unprotected carboxyl groups

    Lourdes A. Salvador;Mikael Elofsson;Jan Kihlberg

  • Building blocks for glycopeptide synthesis: glycosylation of 3-mercaptopropionic acid and Fmoc amino acids with unprotected carboxyl groups

    Mikael Elofsson;Björn Walse;Jan Kihlberg

  • T Cells Recognize a Glycopeptide Derived from Type II Collagen in a Model for Rheumatoid Arthritis

    Johan Broddefalk;Johan Bäcklund;Fredrik Almqvist;Martin Johansson

Frequent Co-Authors

Rikard Holmdahl
Rikard Holmdahl Karolinska Institute
Scott J. Hultgren
Scott J. Hultgren Washington University in St. Louis
Jerome S. Pinkner
Jerome S. Pinkner Washington University in St. Louis
Celso A. Reis
Celso A. Reis University of Porto
Kristina Luthman
Kristina Luthman University of Gothenburg
Henrik Clausen
Henrik Clausen University of Copenhagen
Ulf J. Nilsson
Ulf J. Nilsson Lund University
Emil R. Unanue
Emil R. Unanue Washington University in St. Louis
Per Artursson
Per Artursson Uppsala University
Torbjörn Drakenberg
Torbjörn Drakenberg Lund University

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