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Biology and Biochemistry

D-Index
59
Citations
12650
World Ranking
12523
National Ranking
136

Overview

Ulla Mandel is affiliated with the University of Copenhagen in Denmark. Their research spans multiple fields, primarily focusing on biochemistry, genetics, and molecular biology, alongside medicine. The subfields most represented in their work include molecular biology, immunology, cell biology, physiology, and oncology.

The scientist's research centers extensively on glycosylation and glycoproteins, with additional topics covering carbohydrate chemistry and synthesis, cellular transport and secretion, lysosomal storage disorders, immune cells in cancer, cancer metabolism under hypoxia, and monoclonal and polyclonal antibodies.

Mandel's recent publications feature studies on various aspects of glycobiology and molecular mechanisms associated with cancer and cellular processes:

  • Display of the human mucinome with defined O-glycans by gene engineered cells, 2021, Nature Communications
  • Golgi maturation-dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3, 2021, The EMBO Journal
  • Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype, 2020, Communications Biology
  • Isoforms of MUC16 activate oncogenic signaling through EGF receptors to enhance the progression of pancreatic cancer, 2020, Molecular Therapy
  • A universal GlycoDesign for lysosomal replacement enzymes to improve circulation time and biodistribution, 2023, Frontiers in Bioengineering and Biotechnology

Frequent collaborators include Henrik Clausen, Zilu Ye, Sergey Y. Vakhrushev, Yoshiki Narimatsu, and Rebecca Nason. Their collaboration patterns indicate an interdisciplinary approach involving expertise in glycobiology and molecular research.

Publication venues associated with Mandel's work reflect a presence in journals of molecular biology and biotechnology, including Nature Communications, The EMBO Journal, Communications Biology, Molecular Therapy, and Frontiers in Bioengineering and Biotechnology.

Best Publications

  • Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology

    Catharina Steentoft;Sergey Vakhrushev;Hiren Jitendra Joshi;Hiren Jitendra Joshi;Yun Kong

  • Control of mucin-type O-glycosylation: A classification of the polypeptide GalNAc-transferase gene family

    Eric P Bennett;Ulla Mandel;Henrik Clausen;Thomas A Gerken

  • Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma.

    Avery D. Posey;Robert D. Schwab;Alina C. Boesteanu;Catharina Steentoft

  • Polypeptide GalNAc-transferase T3 and Familial Tumoral Calcinosis SECRETION OF FIBROBLAST GROWTH FACTOR 23 REQUIRES O-GLYCOSYLATION

    Kentaro Kato;Charlotte Jeanneau;Mads Agervig Tarp;Anna Benet-Pagès

  • Mining the O-glycoproteome using zinc-finger nuclease-glycoengineered SimpleCell lines

    Catharina Steentoft;Sergey Y Vakhrushev;Malene B Vester-Christensen;Katrine T-B G Schjoldager

  • Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat.

    Eric Paul Bennett;Helle Hassan;Ulla Mandel;Ekatarina Mirgorodskaya

  • Chemoenzymatically synthesized multimeric Tn/STn MUC1 glycopeptides elicit cancer-specific anti-MUC1 antibody responses and override tolerance.

    Anne Louise Sørensen;Celso A. Reis;Celso A. Reis;Mads A. Tarp;Ulla Mandel

  • Identification of a novel cancer-specific immunodominant glycopeptide epitope in the MUC1 tandem repeat.

    Mads A. Tarp;Anne Louise Sørensen;Ulla Mandel;Hans Paulsen

  • Cancer Biomarkers Defined by Autoantibody Signatures to Aberrant O-Glycopeptide Epitopes

    Hans H. Wandall;Ola Blixt;Mads A. Tarp;Johannes W. Pedersen

  • Cloning and Expression of a Proteoglycan UDP-Galactose:β-Xylose β1,4-Galactosyltransferase I A SEVENTH MEMBER OF THE HUMAN β4-GALACTOSYLTRANSFERASE GENE FAMILY

    Raquel Almeida;Steven B. Levery;Ulla Mandel;Hans Kresse

  • Cloning and Characterization of a Close Homologue of Human UDP-N-acetyl-α-d-galactosamine:Polypeptide N-Acetylgalactosaminyltransferase-T3, Designated GalNAc-T6 EVIDENCE FOR GENETIC BUT NOT FUNCTIONAL REDUNDANCY

    Eric Paul Bennett;Helle Hassan;Ulla Mandel;Michael A. Hollingsworth

  • An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells

    Yoshiki Narimatsu;Hiren J. Joshi;Rebecca Nason;Julie Van Coillie

  • Immunohistochemical study of the expression of MUC6 mucin and co-expression of other secreted mucins (MUC5AC and MUC2) in human gastric carcinomas.

    Celso A. Reis;Celso A. Reis;Leonor David;Filipa Carvalho;Ulla Mandel

  • Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine : polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals - One subfamily composed of l(2)35Aa is essential in Drosophila

    Tilo Schwientek;Eric P. Bennett;Carlos Flores;John Thacker

  • Distribution of laminin and fibronectin isoforms in oral mucosa and oral squamous cell carcinoma

    H Kosmehl;A Berndt;S Strassburger;L Borsi

  • Expression of polypeptide GalNAc-transferases in stratified epithelia and squamous cell carcinomas: immunohistological evaluation using monoclonal antibodies to three members of the GalNAc-transferase family

    Ulla Mandel;Helle Hassan;Marianne H. Therkildsen;Jørgen Rygaard

  • Aberrant Expression of Mucin Core Proteins and O-Linked Glycans Associated with Progression of Pancreatic Cancer

    Neeley Remmers;Judy M. Anderson;Erin M. Linde;Dominick J. DiMaio

  • Tumor-associated Tn-MUC1 glycoform is internalized through the macrophage galactose-type C-Type lectin and delivered to the HLA class I and II compartments in dendritic cells

    Chiara Napoletano;Aurelia Rughetti;Mads P. Agervig Tarp;Julia Coleman

  • Over-expression of ST3Gal-I promotes mammary tumorigenesis

    Gianfranco Picco;Sylvain Julien;Inka Brockhausen;Richard Beatson

  • Seromic profiling of colorectal cancer patients with novel glycopeptide microarray

    Johannes W. Pedersen;Ola Blixt;Eric P. Bennett;Mads A. Tarp

Frequent Co-Authors

Henrik Clausen
Henrik Clausen University of Copenhagen
Eric P. Bennett
Eric P. Bennett University of Copenhagen
Hans H. Wandall
Hans H. Wandall University of Copenhagen
Celso A. Reis
Celso A. Reis University of Porto
Joy M. Burchell
Joy M. Burchell King's College London
Joyce Taylor-Papadimitriou
Joyce Taylor-Papadimitriou King's College London
Steven B. Levery
Steven B. Levery University of Copenhagen
Michael A. Hollingsworth
Michael A. Hollingsworth University of Nebraska Medical Center
Ola Blixt
Ola Blixt University of Copenhagen
Sen-itiroh Hakomori
Sen-itiroh Hakomori Pacific Northwest Diabetes Research Institute

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