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Hiroko Iwasaki

Hiroko Iwasaki

D-Index & Metrics

Biology and Biochemistry

D-Index
44
Citations
7067
World Ranking
19300
National Ranking
1393

Overview

Hiroko Iwasaki is affiliated with Keio University in Japan and has contributed to research primarily in the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Their work covers several subfields including Immunology, Molecular Biology, Physiology, Public Health, Environmental and Occupational Health, and Infectious Diseases.

The scientist's research topics show a focus on molecular and cellular mechanisms in health and disease. Key areas include Galectins and Cancer Biology, Invertebrate Immune Response Mechanisms, Studies on Chitinases and Chitosanases, Alzheimer's Disease Research and Treatments, Mitochondrial Function and Pathology, Genetics and Neurodevelopmental Disorders, and Bone and Dental Protein Studies.

Recent notable publications by Hiroko Iwasaki include:

  • Blood Levels of Galectin-9, an Immuno-Regulating Molecule, Reflect the Severity for the Acute and Chronic Infectious Diseases (2021, Biomolecules)
  • Plasma N-Cleaved Galectin-9 Is a Surrogate Marker for Determining the Severity of COVID-19 and Monitoring the Therapeutic Effects of Tocilizumab (2023, International Journal of Molecular Sciences)

Frequent coauthors collaborating with Iwasaki are:

  • Toshio Hattori
  • Gaowa Bai
  • Takashi Matsuba
  • Haorile Chagan-Yasutan
  • Yugo Ashino

Research publications involving Iwasaki have appeared in journals such as Biomolecules, International Journal of Molecular Sciences, Biomedicines, Communications Biology, and BMC Medical Education.

Through interdisciplinary research, Iwasaki's work spans molecular biology techniques and clinical insights, particularly investigating immunoregulatory molecules like Galectin-9 in infectious diseases and exploring molecular markers related to disease severity and therapeutic monitoring. Their research contributes to understanding the molecular basis and potential diagnostic tools in the context of infectious and neurodegenerative diseases.

Best Publications

  • Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche

    Hiroki Yoshihara;Fumio Arai;Kentaro Hosokawa;Tetsuya Hagiwara

  • Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells

    Yuka Nakamura;Fumio Arai;Hiroko Iwasaki;Kentaro Hosokawa

  • Molecular cloning and characterization of a novel UDP-GlcNAc : GalNAc-peptide β1,3-N-acetylglucosaminyltransferase (β3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans

    Toshie Iwai;Niro Inaba;Andreas Naundorf;Andreas Naundorf;Yan Zhang

  • Lewis and Secretor Gene Dosages Affect CA19-9 and DU-PAN-2 Serum Levels in Normal Individuals and Colorectal Cancer Patients

    Hisashi Narimatsu;Hiroko Iwasaki;Fumiaki Nakayama;Yuzuru Ikehara

  • Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

    Sahoko Matsuoka;Yuichi Oike;Yuichi Oike;Ichiro Onoyama;Atsushi Iwama

  • Molecular Genetic Analysis of the Human Lewis Histo-blood Group System*

    S Nishihara;H Narimatsu;H Iwasaki;S Yazawa

  • Cancer stem cells and their niche.

    Hiroko Iwasaki;Toshio Suda

  • Cloning and Characterization of a New Human UDP-N-Acetyl-α-d-galactosamine:PolypeptideN-Acetylgalactosaminyltransferase, Designated pp-GalNAc-T13, That Is Specifically Expressed in Neurons and Synthesizes GalNAc α-Serine/Threonine Antigen *

    Yan Zhang;Hiroko Iwasaki;Hiroko Iwasaki;Han Wang;Takashi Kudo

  • α1,3-Fucoslytransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX

    Mika Kaneko;Mika Kaneko;Takashi Kudo;Hiroko Iwasaki;Yuzuru Ikehara

  • Molecular Genetic Analysis of the Human Lewis Histo-blood Group System II. SECRETOR GENE INACTIVATION BY A NOVEL SINGLE MISSENSE MUTATION A385T IN JAPANESE NONSECRETOR INDIVIDUALS

    Takashi Kudo;Hiroko Iwasaki;Shoko Nishihara;Naoko Shinya

  • Molecular Cloning and Characterization of UDP-GlcNAc:Lactosylceramide β1,3-N-Acetylglucosaminyltransferase (β3Gn-T5), an Essential Enzyme for the Expression of HNK-1 and Lewis X Epitopes on Glycolipids

    Akira Togayachi;Tomohiro Akashima;Tomohiro Akashima;Reiko Ookubo;Takashi Kudo

  • Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction

    Kentaro Hosokawa;Fumio Arai;Hiroki Yoshihara;Yuka Nakamura

  • Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells

    Kentaro Hosokawa;Fumio Arai;Hiroki Yoshihara;Hiroko Iwasaki

  • CD15 Expression in Mature Granulocytes Is Determined by α1,3-Fucosyltransferase IX, but in Promyelocytes and Monocytes by α1,3-Fucosyltransferase IV

    Fumiaki Nakayama;Shoko Nishihara;Hiroko Iwasaki;Takashi Kudo

  • Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver

    Hiroko Iwasaki;Fumio Arai;Yoshiaki Kubota;Maria Dahl

  • Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T15.

    Lamei Cheng;Kouichi Tachibana;Yan Zhang;Jian ming Guo

  • Molecular Cloning and Characterization of a Novel Human β1,4-N-Acetylgalactosaminyltransferase, β4GalNAc-T3, Responsible for the Synthesis of N,N′-Diacetyllactosediamine, GalNAcβ1–4GlcNAc

    Takashi Sato;Masanori Gotoh;Masanori Gotoh;Katsue Kiyohara;Akihiko Kameyama;Akihiko Kameyama

  • Differential Roles of TwoN-Acetylgalactosaminyltransferases, CSGalNAcT-1, and a Novel Enzyme, CSGalNAcT-2 INITIATION AND ELONGATION IN SYNTHESIS OF CHONDROITIN SULFATE

    Takashi Sato;Masanori Gotoh;Masanori Gotoh;Katsue Kiyohara;Tomohiro Akashima

  • α1,3-Fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four α1,3FUT members preferentially fucosylate the inner GlcNAc residue

    Shoko Nishihara;Hiroko Iwasaki;Mika Kaneko;Akira Tawada

  • Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis.

    Masanori Gotoh;Masanori Gotoh;Takashi Sato;Tomohiro Akashima;Hiroko Iwasaki;Hiroko Iwasaki

Frequent Co-Authors

Hisashi Narimatsu
Hisashi Narimatsu National Institute of Advanced Industrial Science and Technology
Takashi Kudo
Takashi Kudo University of Tsukuba
Yuzuru Ikehara
Yuzuru Ikehara Chiba University
Koji Kimata
Koji Kimata Aichi Medical University
Hidetoshi Inoko
Hidetoshi Inoko Tokai University
Setsuo Hirohashi
Setsuo Hirohashi National Cancer Research Institute, UK
Naruya Saitou
Naruya Saitou National Institute of Genetics
Jianguo Gu
Jianguo Gu Tohoku Medical and Pharmaceutical University
Seiamak Bahram
Seiamak Bahram University of Strasbourg

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