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Clifford P. Brangwynne

Clifford P. Brangwynne

D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
32337
World Ranking
11086
National Ranking
4793

Research.com Recognitions

  • 2018 - Fellow of the MacArthur Foundation
  • 2014 - Fellow of Alfred P. Sloan Foundation

Overview

Clifford P. Brangwynne is affiliated with Princeton University in the United States and has produced extensive work in the field of Biochemistry, Genetics, and Molecular Biology. Their research spans several subfields, including Molecular Biology, Cell Biology, Infectious Diseases, Plant Science, and Biochemistry. The primary focus of their studies revolves around RNA Research and Splicing, Genomics and Chromatin Dynamics, RNA modifications and cancer, RNA and protein synthesis mechanisms, Nuclear Structure and Function, Protein Structure and Dynamics, and interferon and immune responses.

Their recent publications highlight a diverse and active research presence. Notable papers include:

  • "The nucleolus as a multiphase liquid condensate," 2020, Nature Reviews Molecular Cell Biology
  • "Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization," 2020, Cell
  • "Composition-dependent thermodynamics of intracellular phase separation," 2020, Nature
  • "Nucleated transcriptional condensates amplify gene expression," 2020, Nature Cell Biology
  • "Capillary forces generated by biomolecular condensates," 2022, Nature

Brangwynne has collaborated frequently with several coauthors who have contributed significantly to their joint research efforts. These collaborators include Amy R. Strom, Daniel S.W. Lee, Ned S. Wingreen, Jorine M. Eeftens, and David W. Sanders.

Their publications appear most frequently in venues such as bioRxiv (Cold Spring Harbor Laboratory), Biophysical Journal, Nature, eLife, and Nature Communications.

Brangwynne's awards include being named a Fellow of the MacArthur Foundation in 2018 and a Fellow of the Alfred P. Sloan Foundation in 2014.

Best Publications

  • Liquid phase condensation in cell physiology and disease.

    Yongdae Shin;Clifford P. Brangwynne

  • Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

    Clifford P. Brangwynne;Christian R. Eckmann;David S. Courson;Agata Rybarska

  • Coexisting Liquid Phases Underlie Nucleolar Subcompartments

    Marina Feric;Nilesh Vaidya;Tyler S. Harmon;Diana M. Mitrea

  • Polymer physics of intracellular phase transitions

    Clifford P. Brangwynne;Peter Tompa;Peter Tompa;Rohit V. Pappu

  • Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes.

    Clifford P. Brangwynne;Timothy J. Mitchison;Anthony A. Hyman

  • The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics

    Shana Elbaum-Garfinkle;Younghoon Kim;Krzysztof Jakub Szczepaniak;Carlos Chih-Hsiung Chen

  • Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement

    Clifford P. Brangwynne;Frederick C. MacKintosh;Sanjay Kumar;Nicholas A. Geisse

  • Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets

    Yongdae Shin;Joel Berry;Nicole Pannucci;Mikko P. Haataja

  • The nucleolus as a multiphase liquid condensate

    Denis L. J. Lafontaine;Joshua A. Riback;Rümeyza Bascetin;Clifford P. Brangwynne

  • RNA Controls PolyQ Protein Phase Transitions

    Huaiying Zhang;Shana Elbaum-Garfinkle;Erin M. Langdon;Nicole Taylor

  • Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization

    David W. Sanders;Nancy Kedersha;Daniel S.W. Lee;Amy R. Strom

  • Phase behaviour of disordered proteins underlying low density and high permeability of liquid organelles.

    Ming Tzo Wei;Shana Elbaum-Garfinkle;Alex S. Holehouse;Carlos Chih Hsiung Chen

  • Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome.

    Yongdae Shin;Yongdae Shin;Yi Che Chang;Daniel S.W. Lee;Joel Berry

  • Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces

    Kevin Kit Parker;Amy Lepre Brock;Cliff Brangwynne;Robert J. Mannix

  • The cell as a material.

    Karen E Kasza;Amy C Rowat;Jiayu Liu;Thomas E Angelini

  • Composition-dependent thermodynamics of intracellular phase separation

    Joshua A. Riback;Lian Zhu;Mylene C. Ferrolino;Michele Tolbert

  • Getting RNA and Protein in Phase

    Stephanie C. Weber;Clifford P. Brangwynne

  • RNA transcription modulates phase transition-driven nuclear body assembly

    Joel Berry;Stephanie C. Weber;Nilesh Vaidya;Mikko Haataja

  • Phase transitions and size scaling of membrane-less organelles.

    Clifford P. Brangwynne

  • Physical principles of intracellular organization via active and passive phase transitions

    Joel Berry;Clifford P Brangwynne;Mikko Haataja

Frequent Co-Authors

David A. Weitz
David A. Weitz Harvard University
Anthony A. Hyman
Anthony A. Hyman Max Planck Institute of Molecular Cell Biology and Genetics
Ned S. Wingreen
Ned S. Wingreen Princeton University
Gijsje H. Koenderink
Gijsje H. Koenderink Delft University of Technology
Frank Jülicher
Frank Jülicher Max Planck Society
Fred C. MacKintosh
Fred C. MacKintosh Rice University
Donald E. Ingber
Donald E. Ingber Harvard University
John F. Marko
John F. Marko Northwestern University
Rodney D. Priestley
Rodney D. Priestley Princeton University

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