His primary areas of study are Cell biology, Chondrocyte, Signal transduction, Apoptosis and Cartilage. The various areas that Mehdi Shakibaei examines in his Cell biology study include Integrin, Programmed cell death and Immunology. His Chondrocyte study incorporates themes from Carbohydrate metabolism and Cell growth.
His biological study spans a wide range of topics, including NFKB1, Curcumin, Pharmacology and Cytokine. His Apoptosis study integrates concerns from other disciplines, such as Kinase and Clinostat. The Cartilage study combines topics in areas such as Tissue engineering, Osteoarthritis and Mesenchymal stem cell.
His primary areas of investigation include Cell biology, Internal medicine, Endocrinology, Cartilage and Chondrocyte. His Cell biology research is multidisciplinary, incorporating perspectives in Apoptosis, Integrin and Immunology. His Apoptosis research includes elements of Cancer cell and Curcumin, Pharmacology.
His research integrates issues of Magnesium deficiency, Heart failure and Toxicity in his study of Endocrinology. His Cartilage research focuses on Mesenchymal stem cell and how it relates to Regenerative medicine. His research in Chondrocyte intersects with topics in Molecular biology, Matrix metalloproteinase and Transplantation.
His primary scientific interests are in Cancer research, Cancer cell, Resveratrol, Apoptosis and Internal medicine. His studies examine the connections between Cancer cell and genetics, as well as such issues in Epithelial–mesenchymal transition, with regards to Vimentin and Matrix metalloproteinase. His Resveratrol research integrates issues from Tumor necrosis factor alpha, Sirtuin 1, Cell growth and Cell biology.
Many of his research projects under Cell biology are closely connected to Sodium channel with Sodium channel, tying the diverse disciplines of science together. His Apoptosis research is multidisciplinary, incorporating elements of Tumor microenvironment, Curcumin and CXCR4. His work deals with themes such as Endocrinology, Protein kinase C and Oncology, which intersect with Internal medicine.
His scientific interests lie mostly in Cancer research, Resveratrol, Carcinogenesis, Cancer and Cancer cell. In his study, which falls under the umbrella issue of Cancer research, CD44, Cytokine and CXCR4 is strongly linked to Cancer stem cell. His Resveratrol study combines topics from a wide range of disciplines, such as Cell growth, Focal adhesion, Tumor microenvironment and Viability assay, Apoptosis.
His Carcinogenesis research incorporates elements of Signal transduction, Disease and In vivo. His work carried out in the field of Lymphotoxin beta receptor brings together such families of science as Inflammation, Sirtuin 1 and Cell biology. His work on Extracellular matrix and Progenitor cell as part of general Cell biology study is frequently connected to Premature aging, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them.
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Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants.
H. Zreiqat;C. R. Howlett;A. Zannettino;P. Evans.
Journal of Biomedical Materials Research (2002)
Suppression of NF-κB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis
Mehdi Shakibaei;Thilo John;Gundula Schulze-Tanzil;Ingo Lehmann.
Biochemical Pharmacology (2007)
Resveratrol addiction: To die or not to die
Mehdi Shakibaei;Kuzhuvelil B. Harikumar;Bharat B. Aggarwal.
Molecular Nutrition & Food Research (2009)
Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis
Constanze Csaki;Ali Mobasheri;Mehdi Shakibaei.
Arthritis Research & Therapy (2009)
Integrins and stretch activated ion channels; putative components of functional cell surface mechanoreceptors in articular chondrocytes.
A Mobasheri;S D Carter;P Martín-Vasallo;M Shakibaei.
Cell Biology International (2002)
Redifferentiation of dedifferentiated human chondrocytes in high-density cultures.
G. Schulze-Tanzil;P. de Souza;H. Villegas Castrejon;T. John.
Cell and Tissue Research (2002)
Glycosaminoglycan polymerization may enable osmotically inactive Na+ storage in the skin
Jens Titze;Mehdi Shakibaei;Markus Schafflhuber;Gundula Schulze-Tanzil.
American Journal of Physiology-heart and Circulatory Physiology (2004)
Mesenchymal stem cells in regenerative medicine: opportunities and challenges for articular cartilage and intervertebral disc tissue engineering.
Stephen M. Richardson;Judith A. Hoyland;Reza Mobasheri;Constanze Csaki.
Journal of Cellular Physiology (2010)
Resveratrol suppresses interleukin-1beta-induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis.
Mehdi Shakibaei;Constanze Csaki;Simone Nebrich;Ali Mobasheri.
Biochemical Pharmacology (2008)
Resveratrol-mediated SIRT-1 Interactions With p300 Modulate Receptor Activator of NF-kappaB Ligand (RANKL) Activation of NF-kappaB Signaling and Inhibit Osteoclastogenesis in Bone-Derived Cells
Mehdi Shakibaei;Constanze Buhrmann;Ali Mobasheri.
Journal of Biological Chemistry (2011)
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