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Janet A. Houghton

Janet A. Houghton

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
10272
World Ranking
11052
National Ranking
4776

Overview

Janet A. Houghton was affiliated with the Cleveland Clinic in the United States during their career. Their work concentrated within the domain of medical research, although specific subfields and main topics of study have not been documented in the available data.

Details regarding recent papers, frequent co-authors, or publication venues linked to Janet A. Houghton are not listed, and no record of published books is available. Likewise, there is no information concerning awards or recognitions received throughout their career.

The absence of detailed records on research output, collaborations, and sub-specializations limits a deeper insight into the precise nature and impact of their scientific contributions. Nonetheless, their association with a major clinical institution such as the Cleveland Clinic suggests involvement in clinical or biomedical research contexts.

Janet A. Houghton has been confirmed deceased, and all references to their work are made in past tense to reflect this status.

Best Publications

  • Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance

    Jennifer S. Carew;Steffan T. Nawrocki;Charissa N. Kahue;Hui Zhang

  • Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors

    Peter J. Houghton;Pamela J. Cheshire;James D. Hallman;Lois Lutz

  • Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors.

    Peter J. Houghton;Pamela J. Cheshire;Leann Myers;Clinton F. Stewart

  • Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinomas in mice.

    Janet A. Houghton;Stephen J. Maroda;John O. Phillips;Peter J. Houghton

  • Therapeutic Efficacy of the Topoisomerase I Inhibitor 7-Ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against Human Tumor Xenografts: Lack of Cross-Resistance in Vivo in Tumors with Acquired Resistance to the Topoisomerase I Inhibitor 9-Dimethylaminomethyl-10-hydroxycamptothecin

    Peter J. Houghton;Pamela J. Cheshire;James C. Hallman;Marie C. Bissery

  • Thymineless death in colon carcinoma cells is mediated via Fas signaling

    Janet A. Houghton;Franklin G. Harwood;David M. Tillman

  • Hedgehog signaling drives cellular survival in human colon carcinoma cells.

    Tapati Mazumdar;Jennifer DeVecchio;Ting Shi;Janay Jones

  • Biology of childhood osteogenic sarcoma and potential targets for therapeutic development : Meeting summary

    Richard Gorlick;Peter Anderson;Irene Andrulis;Carola Arndt

  • Shared pathways: death receptors and cytotoxic drugs in cancer therapy.

    Istvan Petak;Janet A. Houghton

  • Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine.

    Janet A. Houghton;Peter J. Houghton;Robert S. Wooten

  • Relationship between topotecan systemic exposure and tumor response in human neuroblastoma xenografts.

    William C. Zamboni;Clinton F. Stewart;Joyce Thompson;Victor M. Santana

  • O6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea

    T P Brent;P J Houghton;J A Houghton

  • Efficacy of systemic administration of irinotecan against neuroblastoma xenografts.

    Joyce Thompson;William C. Zamboni;Pamela J. Cheshire;Lois Lutz

  • Blocking Hedgehog Survival Signaling at the Level of the GLI Genes Induces DNA Damage and Extensive Cell Death in Human Colon Carcinoma Cells

    Tapati Mazumdar;Jennifer DeVecchio;Akwasi Agyeman;Ting Shi

  • Apoptosis and drug response

    Janet A. Houghton

  • Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA.

    Steffan T. Nawrocki;Steffan T. Nawrocki;Jennifer S. Carew;Kirsteen H. Maclean;James F. Courage

  • Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against pediatric and adult central nervous system tumor xenografts.

    C. Bradley Hare;Gertrude B. Elion;Peter J. Houghton;Janet A. Houghton

  • p53 dependence of Fas induction and acute apoptosis in response to 5-fluorouracil-leucovorin in human colon carcinoma cell lines.

    Istvan Petak;David M. Tillman;Janet A. Houghton

  • Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C.

    David M Tillman;Kamel Izeradjene;Kinga Szekely Szucs;Leslie Douglas

  • Phase II testing of melphalan in children with newly diagnosed rhabdomyosarcoma: a model for anticancer drug development.

    M. E. Horowitz;E. Etcubanas;M. L. Christensen;Janet A Houghton

Frequent Co-Authors

Peter J. Houghton
Peter J. Houghton The University of Texas Health Science Center at San Antonio
Clinton F. Stewart
Clinton F. Stewart St. Jude Children's Research Hospital
John L. Cleveland
John L. Cleveland Moffitt Cancer Center
Henry S. Friedman
Henry S. Friedman Duke University
Peng Huang
Peng Huang Sun Yat-sen University
Mary K. Danks
Mary K. Danks St. Jude Children's Research Hospital
William T. Beck
William T. Beck University of Illinois at Chicago
Robert A. Casero
Robert A. Casero Johns Hopkins University School of Medicine
Douglas R. Green
Douglas R. Green St. Jude Children's Research Hospital
Irene L. Andrulis
Irene L. Andrulis University of Toronto

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Best Scientists Citing Janet A. Houghton