Geoffrey Neale

Overview

Best Publications

• HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

  Lewis Z. Shi;Ruoning Wang;Gonghua Huang;Peter Vogel

  1925
  Citations

• Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

  Rajendra Karki;Bhesh Raj Sharma;Shraddha Tuladhar;Evan Peter Williams

  1614
  Citations

• mTORC1 couples immune signals and metabolic programming to establish T reg -cell function

  Hu Zeng;Kai Yang;Caryn Cloer;Geoffrey Neale

  848
  Citations

• Inflammasome is a central player in the induction of obesity and insulin resistance

  Rinke Stienstra;Janna A. Van Diepen;Cees J. Tack;Hasan Zaki

  805
  Citations

• ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways

  Teneema Kuriakose;Si Ming Man;R. K. Subbarao Malireddi;Rajendra Karki

  771
  Citations

• The genomic landscape of hypodiploid acute lymphoblastic leukemia

  Linda Holmfeldt;Lei Wei;Ernesto Diaz-Flores;Michael Walsh

  768
  Citations

• Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups

  David W. Ellison;James Dalton;Mehmet Kocak;Sarah Leigh Nicholson

  611
  Citations

• Germline genomic variants associated with childhood acute lymphoblastic leukemia.

  Lisa R Treviño;Wenjian Yang;Deborah French;Stephen P Hunger

  596
  Citations

• Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

  Jun Wei;Lingyun Long;Kai Yang;Cliff Guy

  490
  Citations

• T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming

  Kai Yang;Sharad Shrestha;Hu Zeng;Peer W.F. Karmaus

  407
  Citations

• Cross-species genomics matches driver mutations and cell compartments to model ependymoma

  Robert A. Johnson;Karen D. Wright;Helen Poppleton;Kumarasamypet M. Mohankumar

  393
  Citations

• Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses.

  Sharad Shrestha;Kai Yang;Cliff Guy;Peter Vogel

  393
  Citations

• The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

  Si Ming Man;Si Ming Man;Rajendra Karki;R K Subbarao Malireddi;Geoffrey Neale

  384
  Citations

• Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse

  Virginia Perez-Andreu;Kathryn G. Roberts;Richard C. Harvey;Wenjian Yang

  359
  Citations

• mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.

  Hu Zeng;Sivan Cohen;Cliff Guy;Sharad Shrestha

  350
  Citations

• E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.

  Danny T. Huang;Olivier Ayrault;Harold W. Hunt;Asad M. Taherbhoy;Asad M. Taherbhoy

  338
  Citations

• Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.

  Si Ming Man;Qifan Zhu;Qifan Zhu;Liqin Zhu;Zhiping Liu

  323
  Citations

• Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas.

  Tim Forshew;Ruth G Tatevossian;Ruth G Tatevossian;Andrew R J Lawson;Jing Ma

  315
  Citations

• The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function.

  Kai Yang;Geoffrey Neale;Douglas R Green;Weifeng He

  292
  Citations

• COVID-19 cytokines and the hyperactive immune response: Synergism of TNF-α and IFN-γ in triggering inflammation, tissue damage, and death.

  R. Karki;B. R. Sharma;S. Tuladhar;E. P. Williams

  27
  Citations