World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
17901
World Ranking
9522
National Ranking
8

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Amino acid

His main research concerns Cathepsin, Biochemistry, Protein structure, Proteases and Stereochemistry. His Cathepsin study combines topics from a wide range of disciplines, such as Papain and Antigen processing. His Biochemistry study often links to related topics such as Biophysics.

The concepts of his Protein structure study are interwoven with issues in Cysteine protease, Active site, Cathepsin O, Peptide sequence and Binding site. He interconnects Protease, Cysteine and Cell biology in the investigation of issues within Proteases. Dušan Turk works mostly in the field of Stereochemistry, limiting it down to concerns involving Cathepsin B and, occasionally, Substrate.

His most cited work include:

  • Cysteine cathepsins: From structure, function and regulation to new frontiers (723 citations)
  • Lysosomal cysteine proteases: more than scavengers. (677 citations)
  • Lysosomal cysteine proteases: facts and opportunities. (633 citations)

What are the main themes of his work throughout his whole career to date?

Biochemistry, Protease, Stereochemistry, Cathepsin and Severe acute respiratory syndrome coronavirus 2 are his primary areas of study. His work on Biochemistry deals in particular with Proteases, Cathepsin C, Cathepsin O, Cathepsin L and Enzyme. His research integrates issues of Trypsin and Virology in his study of Protease.

The various areas that he examines in his Stereochemistry study include Crystal structure, Active site, Autolysin, Protein structure and Cathepsin B. His study in Active site is interdisciplinary in nature, drawing from both Crystallography and Binding site. His research in Cathepsin intersects with topics in Antigen processing, Cysteine and Cell biology.

He most often published in these fields:

  • Biochemistry (36.87%)
  • Protease (27.27%)
  • Stereochemistry (29.80%)

What were the highlights of his more recent work (between 2017-2021)?

  • Protease (27.27%)
  • Severe acute respiratory syndrome coronavirus 2 (15.15%)
  • Virology (13.64%)

In recent papers he was focusing on the following fields of study:

Dušan Turk mainly focuses on Protease, Severe acute respiratory syndrome coronavirus 2, Virology, Stereochemistry and Biochemistry. The study incorporates disciplines such as Drug development, Drug, Peptidomimetic and Cysteine in addition to Protease. The Stereochemistry study combines topics in areas such as Covalent bond, Glycoside hydrolase, Small molecule and Staphylococcus aureus.

Proteases, Protein precursor, In vitro, Binding site and Nucleotide are among the areas of Biochemistry where Dušan Turk concentrates his study. His Proteases research integrates issues from Thermophile, Cathepsin, Proteolytic enzymes, Proteolysis and Subtilisin. Dušan Turk is involved in the study of Cathepsin that focuses on Cathepsin L in particular.

Between 2017 and 2021, his most popular works were:

  • Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes (40 citations)
  • The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K (27 citations)
  • Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples (19 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Amino acid

Dušan Turk mostly deals with Protease, Cysteine, Stereochemistry, Biochemistry and Cathepsin. His Protease research includes themes of Virology, Drug development, Drug, Peptidomimetic and Allosteric regulation. His Cysteine research focuses on subjects like Mechanism, which are linked to Proteolysis, Protease inhibitor, Fibrillogenesis and Cytosol.

Dušan Turk has included themes like Covalent bond, Autolysin, Small molecule and Glycoside hydrolase in his Stereochemistry study. His studies deal with areas such as Thyroid and Thyroglobulin as well as Biochemistry. His research on Cathepsin frequently links to adjacent areas such as Cell biology.

Best Publications

  • Cysteine cathepsins: From structure, function and regulation to new frontiers

    Vito Turk;Veronika Stoka;Olga Vasiljeva;Miha Renko

  • Lysosomal cysteine proteases: more than scavengers.

    Boris Turk;Dušan Turk;Vito Turk

  • Lysosomal cysteine proteases: facts and opportunities.

    Vito Turk;Boris Turk;Dušan Turk

  • The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships.

    Wolfram Bode;Dusan Turk;Andrej Karshikov

  • The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity.

    D. Musil;D. Zucic;D. Turk;R.A. Engh

  • Structural and functional aspects of papain-like cysteine proteinases and their protein inhibitors.

    Turk B;Turk;Turk D

  • Emerging roles of cysteine cathepsins in disease and their potential as drug targets.

    Olga Vasiljeva;Thomas Reinheckel;Christoph Peters;Dusan Turk

  • Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor

    Carlos Fernandez‐Catalan;Wolfram Bode;Robert Huber;Dusan Turk

  • Cystatins: biochemical and structural properties, and medical relevance.

    Vito Turk;Veronika Stoka;Dusan Turk

  • Regulating Cysteine Protease Activity: Essential Role of Protease Inhibitors as Guardians and Regulators

    Boris Turk;Dusan Turk;Guy S. Salvesen

  • X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease.

    Sebastian Günther;Patrick Y. A. Reinke;Yaiza Fernández-García;Julia Lieske

  • Protease signalling: the cutting edge

    Boris Turk;Dus ˘ an Turk;Vito Turk

  • Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases

    Dušan Turk;Vojko Janjić;Igor Štern;Marjetka Podobnik

  • Revised definition of substrate binding sites of papain-like cysteine proteases.

    Dušan Turk;Gregor Gunčar;Marjetka Podobnik;Boris Turk

  • Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics.

    H. Brandstetter;D. Turk;H.W. Hoeffken;D. Grosse

  • Lysosomal cathepsins: structure, role in antigen processing and presentation, and cancer.

    Vito Turk;Boris Turk;Gregor Gunčar;Dušan Turk

  • Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S.

    Gregor Gunčar;Galina Pungerčič;Ivica Klemenčič;Vito Turk

  • Crystal Structure of the Soluble Form of Equinatoxin II, a Pore-Forming Toxin from the Sea Anemone Actinia equina

    Alekos Athanasiadis;Gregor Anderluh;Peter Maček;Dušan Turk

  • Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity

    J Rozman-Pungercar;N Kopitar-Jerala;M Bogyo;M Bogyo;D Turk

  • Two-step membrane binding by equinatoxin II, a pore-forming toxin from the sea anemone, involves an exposed aromatic cluster and a flexible helix

    Qi Hong;Ion Gutiérrez-Aguirre;Ariana Barlič;Petra Malovrh

Frequent Co-Authors

Boris Turk
Boris Turk Jožef Stefan Institute
Vito Turk
Vito Turk Jožef Stefan Institute
Henry N. Chapman
Henry N. Chapman Universität Hamburg
Christian Betzel
Christian Betzel Universität Hamburg
Rolf Hilgenfeld
Rolf Hilgenfeld University of Lübeck
Matthias Rarey
Matthias Rarey Universität Hamburg
Janko Kos
Janko Kos University of Ljubljana
Wolfram Bode
Wolfram Bode Max Planck Society
Sine Larsen
Sine Larsen University of Copenhagen
Guy S. Salvesen
Guy S. Salvesen Sanford Burnham Prebys Medical Discovery Institute

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