World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
17682
World Ranking
13575
National Ranking
5757

Overview

Weiguo Zhang is affiliated with Duke University in the United States and has contributed to research spanning both the fields of Medicine and Engineering. Their work includes topics related to infectious diseases and advanced materials in construction engineering.

The scientist's research covers several key topics including:

  • SARS-CoV-2 and COVID-19 Research
  • Viral gastroenteritis research and epidemiology
  • Innovative concrete reinforcement materials
  • Smart Materials for Construction
  • Concrete Corrosion and Durability
  • Animal Virus Infections Studies
  • RNA Interference and Gene Delivery

Their publication record includes recent papers across a variety of journals and scientific venues. Notable papers include:

  • Extended ORF8 Gene Region Is Valuable in the Epidemiological Investigation of Severe Acute Respiratory Syndrome-Similar Coronavirus, 2020, The Journal of Infectious Diseases
  • DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia, 2021, Scientific Reports
  • Shear behaviors of engineered cementitious composites to seawater sea-sand concrete (ECC-to-SSSC) interfaces cast using 3D-printed pre-grooving formwork: Mechanical properties, characterization, and life-cycle assessment, 2023, Journal of Building Engineering
  • Combined Blockade of CD47-Sirpa Interaction By 5F9 (Magrolimab) and Azacitidine/Venetoclax Therapy Facilitates Macrophage-Mediated Anti-Leukemia Efficacy in AML Pre-Clinical Models, 2021, Blood
  • Feasibility study of smart functional strain-hardening cementitious composites: Self-sensing model and experimental performance, 2024, Construction and Building Materials

The frequent coauthors who have collaborated with them the most include:

  • Yijie Dong
  • Shan Cen
  • Xiaowei Wu
  • Jun Tian
  • Yu Zheng

Weiguo Zhang's research appears regularly in several publication venues, with work published in:

  • Journal of Building Engineering
  • Construction and Building Materials
  • The Journal of Infectious Diseases
  • Scientific Reports
  • Blood

The scientist's focus spans multiple subfields including:

  • Civil and Structural Engineering
  • Infectious Diseases
  • Molecular Biology
  • Immunology
  • Pollution

Best Publications

  • LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.

    Weiguo Zhang;Joanne Sloan-Lancaster;Jason Kitchen;Ronald P Trible

  • Virology, Epidemiology, Pathogenesis, and Control of COVID-19.

    Yuefei Jin;Haiyan Yang;Wangquan Ji;Weidong Wu

  • LAT Palmitoylation: Its Essential Role in Membrane Microdomain Targeting and Tyrosine Phosphorylation during T Cell Activation

    Weiguo Zhang;Ronald P Trible;Lawrence E Samelson

  • Molecular Basis of T Cell Inactivation by CTLA-4

    Kyung Mi Lee;Ellen Chuang;Matthew Griffin;Roli Khattri

  • Essential Role of LAT in T Cell Development

    Weiguo Zhang;Connie L Sommers;Deborah N Burshtyn;Christopher C Stebbins

  • LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway

    Timothy S Finco;Theresa Kadlecek;Weiguo Zhang;Lawrence E Samelson

  • Dynamic Actin Polymerization Drives T Cell Receptor–Induced Spreading: A Role for the Signal Transduction Adaptor LAT

    Stephen C. Bunnell;Veena Kapoor;Ronald P. Trible;Weiguo Zhang

  • Association of Grb2, Gads, and Phospholipase C-γ1 with Phosphorylated LAT Tyrosine Residues EFFECT OF LAT TYROSINE MUTATIONS ON T CELL ANTIGEN RECEPTOR-MEDIATED SIGNALING

    Weiguo Zhang;Weiguo Zhang;Ronald P. Trible;Minghua Zhu;Stanley K. Liu

  • Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis.

    Feihua Wu;Yuan Chi;Yuan Chi;Yuan Chi;Zhonghao Jiang;Zhonghao Jiang;Yuanyuan Xu

  • LAT Is Essential for FcεRI-Mediated Mast Cell Activation

    Shinichiroh Saitoh;Ramachandran Arudchandran;T.Scott Manetz;Weiguo Zhang

  • Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin.

    Ker Yu;Lourdes Toral-Barza;Celine Shi;Wei-Guo Zhang

  • Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition.

    Weiguo Zhang;Aideen C. M. Young;Monica Imarai;Stanley G. Nathenson

  • Genetic Evidence for Differential Coupling of Syk Family Kinases to the T-Cell Receptor: Reconstitution Studies in a ZAP-70-Deficient Jurkat T-Cell Line

    Brandi L. Williams;Kathy L. Schreiber;Weiguo Zhang;Ronald L. Wange

  • Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches.

    Yuefei Jin;Wangquan Ji;Haiyan Yang;Shuaiyin Chen

  • Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

    Weiguo Zhang;Brenda J. Irvin;Ronald P. Trible;Robert T. Abraham

  • The three-dimensional structure of H-2Db at 2.4 Å resolution: Implications for antigen-determinant selection

    Aideen C.M. Young;Weiguo Zhang;James C. Sacchettini;Stanley G. Nathenson

  • Transmembrane adaptor proteins: organizers of immunoreceptor signalling

    Václav Ho rcaron;ejší;Weiguo Zhang;Burkhart Schraven

  • Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2

    Ker Yu;Celine Shi;Lourdes Toral-Barza;Judy Lucas

  • LAT Is Required for Tyrosine Phosphorylation of Phospholipase Cγ2 and Platelet Activation by the Collagen Receptor GPVI

    Jean-Max Pasquet;Barbara Gross;Lynn Quek;Naoki Asazuma

  • LAB: a new membrane-associated adaptor molecule in B cell activation.

    Erin Janssen;Minghua Zhu;Weijia Zhang;Surapong Koonpaew

Frequent Co-Authors

Lawrence E. Samelson
Lawrence E. Samelson National Institutes of Health
Robert T. Abraham
Robert T. Abraham Pfizer (United States)
Demin Wang
Demin Wang Medical College of Wisconsin
Tarek S. Mansour
Tarek S. Mansour Pfizer (United States)
Stanley G. Nathenson
Stanley G. Nathenson Albert Einstein College of Medicine
Paul E. Love
Paul E. Love National Institutes of Health
James C. Sacchettini
James C. Sacchettini Texas A&M University
Qi-Jing Li
Qi-Jing Li Duke University
Arthur Weiss
Arthur Weiss University of California, San Francisco
Paul J. Leibson
Paul J. Leibson Mayo Clinic

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