World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
65
Citations
19684
World Ranking
2473
National Ranking
214

Overview

Patricia A. Bradford is primarily affiliated with AstraZeneca in the United Kingdom. Their research output focuses heavily on the fields of biochemistry, genetics and molecular biology, as well as medicine. Within these broad areas, the scientist has contributed extensively to molecular medicine, pharmacology, applied microbiology and biotechnology, epidemiology, and pollution.

The main topics of their work center around antibiotic resistance in bacteria, antibiotics pharmacokinetics and efficacy, and antibiotic use and resistance. Additional research interests include pneumonia and respiratory infections, pharmaceutical and antibiotic environmental impacts, antimicrobial resistance in Staphylococcus, and bacterial identification and susceptibility testing.

Frequent coauthors in their scholarly collaborations include Gregory G. Stone, Karen Bush, Wright W. Nichols, Mariana Castanheira, and Alita A. Miller.

The scientist has published multiple papers across a variety of prominent journals. Frequent publication venues include the Journal of Antimicrobial Chemotherapy with six papers, Antimicrobial Agents and Chemotherapy with four, JAC-Antimicrobial Resistance with two, ClinMicroNow with two, and Clinical Microbiology Reviews with one.

Selected recent papers authored or coauthored by the scientist include:

  • Zoliflodacin: An Oral Spiropyrimidinetrione Antibiotic for the Treatment of Neisseria gonorrheae, Including Multi-Drug-Resistant Isolates (2020, ACS Infectious Diseases)
  • Consensus on β-Lactamase Nomenclature (2022, Antimicrobial Agents and Chemotherapy)

Other notable papers in the research context include:

  • Epidemiology of β-Lactamase-Producing Pathogens (2020, Clinical Microbiology Reviews)
  • Extended-spectrum β-lactamases: an update on their characteristics, epidemiology and detection (2021, JAC-Antimicrobial Resistance)
  • In vitro activity of sulbactam/durlobactam against clinical isolates of Acinetobacter baumannii collected in China (2020, Journal of Antimicrobial Chemotherapy)

Best Publications

  • Extended-Spectrum β-Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance Threat

    Patricia A. Bradford

  • β-Lactams and β-Lactamase Inhibitors: An Overview

    Karen Bush;Patricia A. Bradford

  • Epidemiology of β-Lactamase-Producing Pathogens.

    Karen Bush;Patricia A. Bradford

  • Ceftriaxone-resistant salmonella infection acquired by a child from cattle.

    Paul D. Fey;Thomas J. Safranek;Mark E. Rupp;Eileen F. Dunne

  • Multiple antibiotic-resistant Klebsiella and Escherichia coli in nursing homes.

    Janis Wiener;John P. Quinn;Patricia A. Bradford;Richard V. Goering

  • Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the foss of an outer membrane protein.

    P A Bradford;C Urban;N Mariano;S J Projan

  • Extended-spectrum β-lactamases: an update on their characteristics, epidemiology and detection

    Mariana Castanheira;Patricia J Simner;Patricia A Bradford

  • Emergence of Carbapenem-Resistant Klebsiella Species Possessing the Class A Carbapenem-Hydrolyzing KPC-2 and Inhibitor-Resistant TEM-30 β-Lactamases in New York City

    Patricia A. Bradford;Simona Bratu;Carl Urban;Melissa Visalli

  • Interplay between β-lactamases and new β-lactamase inhibitors.

    Karen Bush;Patricia A. Bradford

  • Efflux-Mediated Resistance to Tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1

    Charles R. Dean;Melissa A. Visalli;Steven J. Projan;Phaik-Eng Sum

  • In vitro antibacterial activities of tigecycline in combination with other antimicrobial agents determined by chequerboard and time-kill kinetic analysis

    Peter J. Petersen;Ponpen Labthavikul;C. Hal Jones;Patricia A. Bradford

  • AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex.

    Alexey Ruzin;David Keeney;Patricia A. Bradford

  • A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline.

    Fionnuala McAleese;Peter Petersen;Alexey Ruzin;Paul M. Dunman

  • Influence of Transcriptional Activator RamA on Expression of Multidrug Efflux Pump AcrAB and Tigecycline Susceptibility in Klebsiella pneumoniae

    Alexey Ruzin;Melissa A. Visalli;David Keeney;Patricia A. Bradford

  • In vitro and in vivo activities of tigecycline (GAR-936), daptomycin, and comparative antimicrobial agents against glycopeptide-intermediate Staphylococcus aureus and other resistant gram-positive pathogens

    Peter J. Petersen;Patricia A. Bradford;William J. Weiss;Timothy M. Murphy

  • Functional, Biophysical, and Structural Bases for Antibacterial Activity of Tigecycline

    Matthew W. Olson;Alexey Ruzin;Eric Feyfant;Thomas S. Rush

  • Multiyear, Multinational Survey of the Incidence and Global Distribution of Metallo-β-Lactamase-Producing Enterobacteriaceae and Pseudomonas aeruginosa.

    Krystyna M. Kazmierczak;Sharon Rabine;Meredith Hackel;Robert E. McLaughlin

  • AcrAB Multidrug Efflux Pump Is Associated with Reduced Levels of Susceptibility to Tigecycline (GAR-936) in Proteus mirabilis

    Melissa A. Visalli;Ellen Murphy;Steven J. Projan;Patricia A. Bradford

  • In Vitro Activity of Aztreonam-Avibactam against Enterobacteriaceae and Pseudomonas aeruginosa Isolated by Clinical Laboratories in 40 Countries from 2012 to 2015.

    James A. Karlowsky;Krystyna M. Kazmierczak;Boudewijn L. M. de Jonge;Meredith A. Hackel

  • MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli

    David Keeney;Alexey Ruzin;Fionnuala McAleese;Ellen Murphy

  • CTX-M-5, a Novel Cefotaxime-Hydrolyzing β-Lactamase from an Outbreak of Salmonella typhimurium in Latvia

    Patricia A. Bradford;Youjun Yang;Daniel Sahm;Ilze Grope

Frequent Co-Authors

Steven J. Projan
Steven J. Projan Rutgers, The State University of New Jersey
Karen Bush
Karen Bush Indiana University
Gisele Peirano
Gisele Peirano University of Calgary
Mary Motyl
Mary Motyl MSD (United States)
Johann D. D. Pitout
Johann D. D. Pitout University of Calgary
James J. Rahal
James J. Rahal New York Hospital Queens
Tarek S. Mansour
Tarek S. Mansour Pfizer (United States)
Christine C. Sanders
Christine C. Sanders Creighton University
Mariana Castanheira
Mariana Castanheira JMI Laboratories
Barry N. Kreiswirth
Barry N. Kreiswirth Center for Discovery and Innovation

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