World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
88
Citations
28760
World Ranking
2699
National Ranking
1400

Research.com Recognitions

  • 2016 - Fellow, National Academy of Inventors

Overview

Garth Powis is affiliated with the Sanford Burnham Prebys Medical Discovery Institute in the United States. Their research lies primarily within the fields of Biochemistry, Genetics, and Molecular Biology, with additional focus on Medicine. Their work extends into several related subfields, including Molecular Biology, Cell Biology, Oncology, Physiology, and Immunology.

The scientist's research topics encompass a range of areas, including:

  • Cellular transport and secretion
  • Erythrocyte Function and Pathophysiology
  • Protein Kinase Regulation and GTPase Signaling
  • Chemokine receptors and signaling
  • Immunotherapy and Immune Responses
  • Chronic Lymphocytic Leukemia Research
  • PI3K/AKT/mTOR signaling in cancer

Garth Powis has published in multiple scientific venues. Frequent publication venues include:

  • Biomedicine & Pharmacotherapy
  • Structure
  • UNC Libraries
  • Experimental Cell Research
  • SLAS DISCOVERY

Recent papers authored or co-authored by Powis are:

  • "Pleckstrin Homology [PH] domain, structure, mechanism, and contribution to human disease" (2023), published in Biomedicine & Pharmacotherapy
  • "Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids" (2021), published in Structure
  • "Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models" (2020), published in UNC Libraries
  • "PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer" (2021), published in Experimental Cell Research
  • "A Robust and Cost-Effective Luminescent-Based High-Throughput Assay for Fructose-1,6-Bisphosphate Aldolase A" (2020), published in SLAS DISCOVERY

The scientist has collaborated frequently with several researchers, including:

  • Alexander E. Aleshin
  • Yong Yao
  • Laurie A. Bankston
  • Robert Liddington
  • Francesca M. Marassi

Garth Powis was recognized as a Fellow of the National Academy of Inventors in 2016.

Best Publications

  • Wortmannin, a Potent and Selective Inhibitor of Phosphatidylinositol-3-kinase

    G Powis;R Bonjouklian;R Bonjouklian;M M Berggren;M M Berggren;A Gallegos;A Gallegos

  • Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy

    Jeffrey M. Arbeit;J. Martin Brown;K. S.Clifford Chao;J. Donald Chapman

  • Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer.

    Scott Kopetz;Jayesh Desai;Emily Chan;Joel Randolph Hecht

  • The role of the redox protein thioredoxin in cell growth and cancer.

    Garth Powis;Debbie Mustacich;Amy Coon

  • Passing the baton: the HIF switch

    Mei Yee Koh;Garth Powis

  • Effect of KRAS Oncogene Substitutions on Protein Behavior: Implications for Signaling and Clinical Outcome

    Nathan T. Ihle;Lauren Averett Byers;Edward S. Kim;Pierre Saintigny

  • The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice.

    Larisa Nonn;Ryan R. Williams;Robert P. Erickson;Garth Powis

  • Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer.

    Andrzej Weichsel;John R Gasdaska;Garth Powis;William R Montfort

  • HIF-1 regulation: not so easy come, easy go

    Mei Yee Koh;Taly R. Spivak-Kroizman;Garth Powis

  • Redox signalling and the control of cell growth and death

    Garth Powis;Margaret Briehl;John Oblong

  • The Hypoxia-Associated Factor Switches Cells from HIF-1α– to HIF-2α–Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion

    Mei Yee Koh;Robert Lemos;Xiuping Liu;Garth Powis

  • Cytosolic NAD(P)H:(quinone-acceptor)oxidoreductase in human normal and tumor tissue : effects of cigarette smoking and alcohol

    John J. Schlager;Garth Powis

  • Thioredoxin signaling as a target for cancer therapy

    Garth Powis;D Lynn Kirkpatrick

  • Redox potential of human thioredoxin 1 and identification of a second dithiol/disulfide motif.

    Walter H. Watson;Jan Pohl;William R. Montfort;Olga Stuchlik

  • Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance

    Nathan T. Ihle;Robert Lemos;Peter Wipf;Adly Yacoub

  • Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents

    Muling Mao;Feng Tian;John M. Mariadason;Chun C. Tsao

  • Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues

    A. F. Howie;L. M. Forrester;M. J. Glancey;J. J. Schlager

  • Increased expression of thioredoxin-1 in human colorectal cancer is associated with decreased patient survival.

    Jennifer Raffel;Achyut K. Bhattacharyya;Alfred Gallegos;Haiyan Cui

  • 3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth.

    Youhong Hu;Lixin Qiao;Shaomeng Wang;Suo-bao Rong

  • Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity

    Emmanuelle J Meuillet;Daruka Mahadevan;Margareta Berggren;Amy Coon

Frequent Co-Authors

Han Liang
Han Liang The University of Texas MD Anderson Cancer Center
Robert T. Abraham
Robert T. Abraham Pfizer (United States)
Alan P. Kozikowski
Alan P. Kozikowski StarWise Therapeutics LLC
Peter Wipf
Peter Wipf University of Pittsburgh
Roy S. Herbst
Roy S. Herbst Yale University
Ignacio I. Wistuba
Ignacio I. Wistuba The University of Texas MD Anderson Cancer Center
Scott Kopetz
Scott Kopetz The University of Texas MD Anderson Cancer Center
W. K. Alfred Yung
W. K. Alfred Yung The University of Texas MD Anderson Cancer Center
John B. Schenkman
John B. Schenkman University of Connecticut Health Center
Daniel D. Von Hoff
Daniel D. Von Hoff Translational Genomics Research Institute

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Pursuing a degree in Biology or Biochemistry opens doors to numerous in-demand healthcare fields. For those considering clinical or technical roles, rad tech online programs provide a flexible way to enter the fast-growing radiological technology sector. These programs typically combine foundational science courses with practical training, preparing you for certification and employment.

If your passion is in nutrition and patient-centered care, exploring one of the best dietitian programs can help you become a registered dietitian or nutritionist. Online options make it easier to balance coursework with personal or professional commitments.

For those seeking entry-level opportunities in healthcare, online medical assistant programs that accept financial aid can be a cost-effective starting point. These programs teach essential administrative and clinical skills, and bridge pathways exist—such as the medical assistant to lpn bridge program—for advancing your career further.

Overall, online degrees offer flexible, affordable pathways to diverse biology- and healthcare-related careers. Exploring your options can help you align your education with your personal goals and the needs of the healthcare industry.

Best Scientists Citing Garth Powis

Trending Scientists