World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
80
Citations
22059
World Ranking
17173
National Ranking
8608

Overview

David R. Harder is affiliated with the Medical College of Wisconsin in the United States. Their research spans multiple fields including Medicine, Neuroscience, and Engineering, with a focus on several specialized subfields such as Molecular Biology, Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology, and Epidemiology.

The scientist's recent publications cover diverse topics related to cerebral metabolic processes, vascular function, and biomedical technology. These papers include:

  • Effect of high glucose condition on glucose metabolism in primary astrocytes, 2020, Brain Research
  • Astrocytic responses to high glucose impair barrier formation in cerebral microvessel endothelial cells, 2022, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
  • Electromagnetic energy (670 nm) stimulates vasodilation through activation of the large conductance potassium channel (BKCa), 2021, PLoS ONE
  • A New Magnetic Measurement System for the Future Low Emittance NSLS-II Storage Ring, 2021, OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)

The main research topics addressed by David R. Harder include:

  • Neuroscience and Neuropharmacology Research
  • Neurogenesis and neuroplasticity mechanisms
  • Mitochondrial Function and Pathology
  • Barrier Structure and Function Studies
  • Connexins and lens biology
  • Acute Ischemic Stroke Management
  • Laser Applications in Dentistry and Medicine

Frequent coauthors who have collaborated on multiple projects are Jodi Garvin, Qiuli Liu, Kevin R. Rarick, Susan Cohen, and Kelly L. Staricha.

The venues where the scientist regularly publishes are:

  • Brain Research
  • American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
  • PLoS ONE
  • OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)

David R. Harder's work integrates concepts from cellular and molecular neuroscience and applies them to medical and engineering challenges, particularly regarding brain metabolism, vascular biology, and biophysical techniques. The scope of their research contributes data relevant to understanding neurological conditions and developing technological advances in biomedical measurements.

Best Publications

  • Identification of Epoxyeicosatrienoic Acids as Endothelium-Derived Hyperpolarizing Factors

    William B. Campbell;Debebe Gebremedhin;Phillip F. Pratt;David R. Harder

  • Cytochrome P450 2C is an EDHF synthase in coronary arteries

    Beate Fisslthaler;Rüdiger Popp;Ladislau Kiss;Michael Potente

  • Astrocytes and the regulation of cerebral blood flow.

    Raymond C. Koehler;Richard J. Roman;David R. Harder

  • Pressure-dependent membrane depolarization in cat middle cerebral artery.

    David R. Harder

  • Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current

    Debebe Gebremedhin;Andrew R. Lange;William B. Campbell;Cecilia J. Hillard

  • Production of 20-HETE and Its Role in Autoregulation of Cerebral Blood Flow

    Debebe Gebremedhin;Andrew R. Lange;Timothy F. Lowry;M. Reza Taheri

  • Role of astrocytes in cerebrovascular regulation

    Raymond C. Koehler;Debebe Gebremedhin;David R. Harder

  • Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle.

    D. Gebremedhin;Y. H. Ma;J. R. Falck;R. J. Roman

  • 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles

    Ai Ping Zou;John T. Fleming;John R. Falck;Elizabeth R. Jacobs

  • Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone.

    D R Harder;W B Campbell;R J Roman

  • Pressure-induced myogenic activation of cat cerebral arteries is dependent on intact endothelium.

    D R Harder

  • 20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries.

    Yunn Hwa Ma;Debebe Gebremedhin;Michal L. Schwartzman;John R. Falck

  • Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles

    John D. Imig;Ai Ping Zou;Dave E. Stec;David R. Harder

  • Endothelium-Derived Hyperpolarizing Factors and Vascular Cytochrome P450 Metabolites of Arachidonic Acid in the Regulation of Tone

    William B. Campbell;David R. Harder

  • Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels.

    D. R. Harder;Debebe Gebremedhin;Jayashree Narayanan;C. Jefcoat

  • Estrogen receptors and effects of estrogen on membrane electrical properties of coronary vascular smooth muscle.

    David R. Harder;Patricia B. Coulson

  • The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans

    Kazuyoshi Toyama;Heike Wulff;K. George Chandy;Philippe Azam

  • Functional Hyperemia in the Brain Hypothesis for Astrocyte-Derived Vasodilator Metabolites

    David R. Harder;Nabil J. Alkayed;Andrew R. Lange;Debebe Gebremedhin

  • 20-Hydroxyeicosatetraenoic acid-induced vasoconstriction and inhibition of potassium current in cerebral vascular smooth muscle is dependent on activation of protein kinase C

    Andrew Lange;Debebe Gebremedhin;Jayashree Narayanan;David Harder

  • Cat cerebral arterial smooth muscle cells express cytochrome P450 4A2 enzyme and produce the vasoconstrictor 20-HETE which enhances L-type Ca2+ current

    Debebe Gebremedhin;Andrew R. Lange;Jayashree Narayanan;Mikael R. Aebly

Frequent Co-Authors

Richard J. Roman
Richard J. Roman University of Mississippi Medical Center
John R. Falck
John R. Falck The University of Texas Southwestern Medical Center
Raymond C. Koehler
Raymond C. Koehler Johns Hopkins University
William B. Campbell
William B. Campbell Medical College of Wisconsin
John D. Imig
John D. Imig Medical College of Wisconsin
Nick Sperelakis
Nick Sperelakis University of Cincinnati Medical Center
Richard J. Traystman
Richard J. Traystman Johns Hopkins University
Howard J. Jacob
Howard J. Jacob AbbVie (United States)
Aron M. Geurts
Aron M. Geurts Medical College of Wisconsin

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