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D-Index
45
Citations
7380
World Ranking
6941
National Ranking
2997

Overview

Richard Bertram is affiliated with Florida State University in the United States. Their research primarily focuses on the intersection of physiology, mathematics, and biophysics, with a significant emphasis on pancreatic function and diabetes. This work extends into related fields such as medicine, neuroscience, and biochemistry, genetics, and molecular biology.

Their scholarly contributions cover several main topics including pancreatic function and diabetes, stochastic dynamics and bifurcation, neural dynamics and brain function, olfactory and sensory function studies, diabetes management and research, metabolism related to diabetes and cancer, and ion channel regulation and function.

Bertram's recent publications include:

  • Deconstructing the integrated oscillator model for pancreatic β-cells, 2023, Mathematical Biosciences
  • Oscillations in K(ATP) conductance drive slow calcium oscillations in pancreatic β-cells, 2022, Biophysical Journal
  • Symbiosis of Electrical and Metabolic Oscillations in Pancreatic β-Cells, 2021, Frontiers in Physiology
  • Canard analysis reveals why a large Ca2+ window current promotes early afterdepolarizations in cardiac myocytes, 2020, PLoS Computational Biology
  • Big Ducks in the Heart: Canard Analysis Can Explain Large Early Afterdepolarizations in Cardiomyocytes, 2020, SIAM Journal on Applied Dynamical Systems

The research often explores complex biological oscillations and their implications for cellular function, particularly focusing on β-cells of the pancreas and cardiac myocytes. Their work frequently employs mathematical and computational analyses to dissect physiological processes contributing to disease mechanisms.

Frequent collaborators in Bertram's work include:

  • Arthur Sherman
  • Leslie S. Satin
  • Isabella Marinelli
  • Patrick A. Fletcher
  • Theodore Vo

Bertram's publications have appeared in a number of consistent venues, reflecting the interdisciplinary nature of their research:

  • Biophysical Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Mathematical Biosciences
  • American Journal of Physiology-Endocrinology and Metabolism
  • The Journal of Physiology

Their research spans several specialized subfields including surgery, molecular biology, statistical and nonlinear physics, cellular and molecular neuroscience, and cognitive neuroscience. This breadth indicates an integrative approach, combining experimental, theoretical, and computational methods to understand biological oscillations and disease pathways.

Best Publications

  • Topological and phenomenological classification of bursting oscillations

    Richard Bertram;Manish J. Butte;Tim Kiemel;Arthur Sherman

  • Metabolic and electrical oscillations: partners in controlling pulsatile insulin secretion.

    Richard Bertram;Arthur Sherman;Leslie S. Satin

  • Ion Channels and Signaling in the Pituitary Gland

    Stanko S. Stojilkovic;Joël Tabak;Richard Bertram

  • Backbone Structure of the Amantadine-Blocked Trans-Membrane Domain M2 Proton Channel from Influenza A Virus

    Jun Hu;Tom Asbury;Srisairam Achuthan;Conggang Li

  • Single-domain/bound calcium hypothesis of transmitter release and facilitation.

    R. Bertram;A. Sherman;E. F. Stanley

  • Multi-timescale systems and fast-slow analysis.

    Richard Bertram;Jonathan E. Rubin

  • A simplified model for mitochondrial ATP production

    Richard Bertram;Morten Gram Pedersen;Dan S. Luciani;Arthur Sherman

  • The Ca2+ Dynamics of Isolated Mouse β-Cells and Islets: Implications for Mathematical Models

    Min Zhang;Paula Goforth;Richard Bertram;Arthur Sherman

  • Calcium and glycolysis mediate multiple bursting modes in pancreatic islets.

    Richard Bertram;Leslie S. Satin;Min Zhang;Paul Smolen

  • Intra- and inter-islet synchronization of metabolically driven insulin secretion.

    Morten Gram Pedersen;Richard Bertram;Arthur Sherman

  • An improved hydrogen bond potential: Impact on medium resolution protein structures

    Felcy Fabiola;Richard Bertram;Andrei Korostelev;Michael S. Chapman

  • The Phantom Burster Model for Pancreatic β-Cells

    Richard Bertram;Joseph Previte;Arthur Sherman;Tracie A. Kinard

  • A calcium-based phantom bursting model for pancreatic islets.

    Richard Bertram;Arthur Sherman

  • Glucose modulates [Ca2+]i oscillations in pancreatic islets via ionic and glycolytic mechanisms

    Craig S. Nunemaker;Richard Bertram;Arthur Sherman;Krasimira Tsaneva-Atanasova

  • A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells

    R. Bertram;Paul D Smolen;A. Sherman;D. Mears

  • Modeling study of the effects of overlapping Ca2+ microdomains on neurotransmitter release

    Richard Bertram;Gregory D. Smith;Arthur Sherman

  • Modeling N-methyl-D-aspartate-induced bursting in dopamine neurons.

    Y.-X. Li;R. Bertram;J. Rinzel

  • Interaction of glycolysis and mitochondrial respiration in metabolic oscillations of pancreatic islets.

    Richard Bertram;Leslie S. Satin;Morten Gram Pedersen;Dan S. Luciani

  • Individual Mice Can Be Distinguished by the Period of Their Islet Calcium Oscillations: Is There an Intrinsic Islet Period That Is Imprinted In Vivo?

    Craig S. Nunemaker;Min Zhang;David H. Wasserman;Owen P. McGuinness

  • Diffusion of Calcium and Metabolites in Pancreatic Islets: Killing Oscillations with a Pitchfork

    Krasimira Tsaneva-Atanasova;Charles L. Zimliki;Richard Bertram;Arthur Sherman

Frequent Co-Authors

Gerald W. Zamponi
Gerald W. Zamponi University of Calgary
John Rinzel
John Rinzel New York University
Tim Kiemel
Tim Kiemel University of Maryland, College Park
Jonathan E. Rubin
Jonathan E. Rubin University of Pittsburgh
Gareth Leng
Gareth Leng University of Edinburgh
Richard Mooney
Richard Mooney Duke University

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