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Microbiology

D-Index
55
Citations
8364
World Ranking
3886
National Ranking
115

Overview

Jim Xiang is affiliated with the University of Saskatchewan in Canada and has a research focus spanning biochemistry, genetics, molecular biology, immunology, microbiology, and medicine. Their academic output also covers specialized subfields including immunology, molecular biology, oncology, physiology, and epidemiology.

The main topics in Xiang's work concentrate on immune cell function and interaction, CAR-T cell therapy research, T-cell and B-cell immunology, autophagy in disease and therapy, advanced biosensing and bioanalysis techniques, RNA interference and gene delivery, and interferon and immune responses.

Notable recent publications by Jim Xiang include:

  • Aptamer-Functionalized Nanoparticles in Targeted Delivery and Cancer Therapy (2020, International Journal of Molecular Sciences)
  • Aptamers, the Nucleic Acid Antibodies, in Cancer Therapy (2020, International Journal of Molecular Sciences)
  • DDX41 is required for cGAS-STING activation against DNA virus infection (2022, Cell Reports)
  • Distinct roles but cooperative effect of TLR3/9 agonists and PD-1 blockade in converting the immunotolerant microenvironment of irreversible electroporation-ablated tumors (2021, Cellular and Molecular Immunology)
  • Activation of Focal Adhesion Kinase Restores Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation via Wnt/Β-Catenin Pathway (2022, International Journal of Molecular Sciences)

Jiang's research has been published frequently in these journals:

  • International Journal of Molecular Sciences (6 publications)
  • Cellular and Molecular Immunology (3 publications)
  • The Journal of Immunology (3 publications)
  • Frontiers in Immunology (2 publications)
  • Cell Reports (1 publication)

Frequent collaborators in Jiang's work include:

  • Zhaojia Wu (9 joint publications)
  • Scot C. Leary (9 joint publications)
  • Aizhang Xu (6 joint publications)
  • Rajni Chibbar (5 joint publications)
  • Junqiong Huang (5 joint publications)

Best Publications

  • Mature dendritic cells pulsed with exosomes stimulate efficient cytotoxic T-lymphocyte responses and antitumour immunity.

    Siguo Hao;Ou Bai;Fang Li;Jinying Yuan

  • HER2-directed therapy: current treatment options for HER2-positive breast cancer

    Shahid Ahmed;Amer Sami;Jim Xiang

  • Efficient antitumor immunity derived from maturation of dendritic cells that had phagocytosed apoptotic/necrotic tumor cells

    Zhuang Chen;Terence Moyana;Anurag Saxena;Robert Warrington

  • Membrane-bound HSP70-engineered myeloma cell-derived exosomes stimulate more efficient CD8(+) CTL- and NK-mediated antitumour immunity than exosomes released from heat-shocked tumour cells expressing cytoplasmic HSP70.

    Yufeng Xie;Ou Bai;Haifeng Zhang;Jinying Yuan

  • A new dynamic model of CD8+ T effector cell responses via CD4+ T helper-antigen-presenting cells.

    Jim Xiang;Hui Huang;Yongqing Liu

  • Aptamer-Functionalized Nanoparticles in Targeted Delivery and Cancer Therapy.

    Zhaoying Fu;Jim Xiang

  • Mechanisms of cellular communication through intercellular protein transfer.

    Khawaja Ashfaque Ahmed;Jim Xiang

  • Dendritic cell-derived exosomes stimulate stronger CD8+ CTL responses and antitumor immunity than tumor cell-derived exosomes.

    Siguo Hao;Ou Bai;Jinying Yuan;Mabood Qureshi

  • Dendritic Cells Recruit T Cell Exosomes via Exosomal LFA-1 Leading to Inhibition of CD8+ CTL Responses through Downregulation of Peptide/MHC Class I and Fas Ligand-Mediated Cytotoxicity

    Yufeng Xie;Haifeng Zhang;Wei Li;Yulin Deng

  • CD4(+) T cell-released exosomes inhibit CD8(+) cytotoxic T-lymphocyte responses and antitumor immunity.

    Haifeng Zhang;Yufeng Xie;Wei Li;Rajni Chibbar

  • Intercellular Trogocytosis Plays an Important Role in Modulation of Immune Responses

    Khawaja Ashfaque Ahmed;Manjunatha Ankathatti Munegowda;Yufeng Xie;Jim Xiang

  • Epigenetic transfer of metastatic activity by uptake of highly metastatic B16 melanoma cell-released exosomes.

    S. Hao;Z. Ye;F. Li;Q. Meng

  • Aptamers, the Nucleic Acid Antibodies, in Cancer Therapy

    Zhaoying Fu;Jim Xiang

  • Th17 and Th17-stimulated CD8 + T cells play a distinct role in Th17-induced preventive and therapeutic antitumor immunity

    Manjunatha Ankathatti Munegowda;Yulin Deng;Sean J. Mulligan;Jim Xiang

  • Eicosapentaenoic acid reduces ABCA1 serine phosphorylation and impairs ABCA1-dependent cholesterol efflux through cyclic AMP/protein kinase A signaling pathway in THP-1 macrophage-derived foam cells

    Yan-Wei Hu;Xin Ma;Xiao-Xu Li;Xie-Hong Liu

  • CD4+ Th1 cells promote CD8+ Tc1 cell survival, memory response, tumor localization and therapy by targeted delivery of interleukin 2 via acquired pMHC I complexes

    Hui Huang;Siguo Hao;Fang Li;Zhenmin Ye

  • IFN-γ down-regulates ABCA1 expression by inhibiting LXRα in a JAK/STAT signaling pathway-dependent manner

    Xin-rui Hao;Dong-li Cao;Yan-wei Hu;Xiao-xu Li

  • One Hundred Seventy-Fold Increase in Excretion of an FV Fragment-Tumor Necrosis Factor Alpha Fusion Protein (sFV/TNF-α) from Escherichia coli Caused by the Synergistic Effects of Glycine and Triton X-100

    Junbao Yang;Terence Moyana;Samuel MacKenzie;Qun Xia

  • Study of B72.3 combining sites by molecular modeling and site-directed mutagenesis

    Jim Xiang;Maheswaran Srivamadan;Raju Rajala;Zongchao Jia

  • Advances in Dendritic Cell-Based Vaccine of Cancer

    Xueshu Zhang;John R. Gordon;Jim Xiang

  • DDX41 is required for cGAS-STING activation against DNA virus infection

    Unknown

  • CD4-8- dendritic cells prime CD4+ T regulatory 1 cells to suppress antitumor immunity

    Xueshu Zhang;Hui Huang;Jinying Yuan;Deming Sun

Frequent Co-Authors

John R. Gordon
John R. Gordon University of Saskatchewan
Yulin Deng
Yulin Deng Georgia Institute of Technology
Yangdou Wei
Yangdou Wei University of Saskatchewan
Zongchao Jia
Zongchao Jia Queen's University
Henry J. Kaplan
Henry J. Kaplan University of Louisville
Lorne A. Babiuk
Lorne A. Babiuk University of Alberta
Zhou Xing
Zhou Xing McMaster University
Philip J. Griebel
Philip J. Griebel University of Saskatchewan
Wenjun Zhang
Wenjun Zhang City University of Hong Kong
Ross M. Kedl
Ross M. Kedl University of Colorado Boulder

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