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Hideki Yamaguchi

Hideki Yamaguchi

D-Index & Metrics

Biology and Biochemistry

D-Index
45
Citations
10503
World Ranking
19058
National Ranking
1374

Overview

Hideki Yamaguchi is affiliated with the Sasaki Institute in Japan and has contributed to research largely within the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their work spans multiple domains including oncology, molecular biology, cell biology, pulmonary and respiratory medicine, and gastroenterology.

The core topics that Yamaguchi has focused on in research include:

  • Cancer Cells and Metastasis
  • Cellular Transport and Secretion
  • Gastrointestinal Tumor Research and Treatment
  • Gastric Cancer Management and Outcomes
  • Cancer Mechanisms and Therapy
  • Pancreatic and Hepatic Oncology Research
  • Cellular Mechanics and Interactions

Yamaguchi's scientific output features a selection of recent papers, illustrating engagement with cancer biology and cell dynamics. Notable publications include:

  • Phosphatidylinositol 4,5-bisphosphate is localized in the plasma membrane outer leaflet and regulates cell adhesion and motility, 2020, Biochemical and Biophysical Research Communications
  • Integrin α5 mediates cancer cell-fibroblast adhesion and peritoneal dissemination of diffuse-type gastric carcinoma, 2021, Cancer Letters
  • Transferrin receptor 1 promotes the fibroblast growth factor receptor-mediated oncogenic potential of diffused-type gastric cancer, 2022, Oncogene
  • PLEKHA5 regulates the survival and peritoneal dissemination of diffuse-type gastric carcinoma cells with Met gene amplification, 2021, Oncogenesis
  • Enhanced Malignant Phenotypes of Glioblastoma Cells Surviving NPe6-Mediated Photodynamic Therapy are Regulated via ERK1/2 Activation, 2020, Cancers

The common venues for Yamaguchi's work include:

  • Cancers
  • Cancer Letters
  • Biochemical and Biophysical Research Communications
  • Oncogene
  • Oncogenesis

Frequent collaborators in Yamaguchi's research network are:

  • Makoto Miyazaki
  • Yuko Nagamura
  • Yoshiko Nagano
  • Kazuyoshi Yanagihara
  • Ryuichi Sakai

Their research presents a strong interdisciplinary engagement with cancer biology and molecular mechanisms underpinning tumor progression and cellular behavior, particularly within gastric carcinoma and glioblastoma contexts. The work contributes to understanding cancer cell adhesion, dissemination, and survival mechanisms, leveraging molecular biology and cell biology insights.

Best Publications

  • Regulation of the actin cytoskeleton in cancer cell migration and invasion

    Hideki Yamaguchi;John Condeelis

  • Cell migration in tumors

    Hideki Yamaguchi;Jeffrey Wyckoff;John Condeelis

  • Molecular mechanisms of invadopodium formation the role of the N-WASP–Arp2/3 complex pathway and cofilin

    Hideki Yamaguchi;Mike Lorenz;Stephan Kempiak;Corina Sarmiento

  • IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

    Hiroaki Miki;Hideki Yamaguchi;Shiro Suetsugu;Tadaomi Takenawa

  • Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation

    Matthew Oser;Hideki Yamaguchi;Hideki Yamaguchi;Christopher C. Mader;J.J. Bravo-Cordero

  • WIP regulates N-WASP-mediated actin polymerization and filopodium formation

    Narcisa Martinez-Quiles;Rajat Rohatgi;Inés M. Antón;Miguel Medina

  • A Mena Invasion Isoform Potentiates EGF-Induced Carcinoma Cell Invasion and Metastasis

    Ulrike Philippar;Evanthia T. Roussos;Matthew Oser;Hideki Yamaguchi;Hideki Yamaguchi

  • N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors.

    Bojana Gligorijevic;Jeffrey Wyckoff;Hideki Yamaguchi;Yarong Wang

  • PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia.

    Tsukasa Oikawa;Hideki Yamaguchi;Toshiki Itoh;Masayoshi Kato

  • Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells.

    Hideki Yamaguchi;Yukiko Takeo;Shuhei Yoshida;Zen Kouchi

  • Imaging sites of N-wasp activity in lamellipodia and invadopodia of carcinoma cells.

    Mike Lorenz;Hideki Yamaguchi;Yarong Wang;Robert H Singer

  • Invadopodia and podosomes in tumor invasion

    Hideki Yamaguchi;Fiona Pixley;John Condeelis

  • Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cells.

    Shusaku Kurisu;Shiro Suetsugu;Daisuke Yamazaki;Hideki Yamaguchi

  • WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells.

    Corina Sarmiento;Weigang Wang;Athanassios Dovas;Hideki Yamaguchi

  • Pathological roles of invadopodia in cancer invasion and metastasis

    Hideki Yamaguchi

  • A Role for Neuropeptide W in the Regulation of Feeding Behavior

    Muhtashan S. Mondal;Hideki Yamaguchi;Yukari Date;Takuya Shimbara

  • Direct Interaction between Carcinoma Cells and Cancer Associated Fibroblasts for the Regulation of Cancer Invasion.

    Hideki Yamaguchi;Ryuichi Sakai

  • N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells.

    Vera DesMarais;Hideki Yamaguchi;Matthew Oser;Lilian Soon

  • Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation

    Hideki Yamaguchi;Shuhei Yoshida;Emi Muroi;Nachi Yoshida

  • Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP.

    Hideki Yamaguchi;Hiroaki Miki;Shiro Suetsugu;Le Ma

Frequent Co-Authors

Kiyoko Fukami
Kiyoko Fukami Tokyo University of Pharmacy and Life Sciences
Masamitsu Nakazato
Masamitsu Nakazato University of Miyazaki
John S. Condeelis
John S. Condeelis Albert Einstein College of Medicine
Tadaomi Takenawa
Tadaomi Takenawa Kobe University
Hiroaki Miki
Hiroaki Miki Osaka University
Kenji Kangawa
Kenji Kangawa National Cerebral and Cardiovascular Center
Shiro Suetsugu
Shiro Suetsugu Nara Institute of Science and Technology
Masakazu Yashiro
Masakazu Yashiro Osaka Metropolitan University
Erik Sahai
Erik Sahai The Francis Crick Institute
Hisayuki Matsuo
Hisayuki Matsuo Osaka University

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