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Medicine

D-Index
75
Citations
22043
World Ranking
19086
National Ranking
9514

Overview

Darryle D. Schoepp is an independent scientist and consultant based in the United States, with a research focus primarily in neuroscience and pharmacology. Their scholarly contributions span several interconnected domains, notably cellular and molecular neuroscience as well as molecular biology. The scientist's work also touches on clinical psychology, biological psychiatry, and neurology.

The main topics covered by their research include neuroscience and neuropharmacology, receptor mechanisms and signaling, psychedelics and drug studies, neurotransmitter receptor influence on behavior, photoreceptor and optogenetics research, tryptophan and brain disorders, and pharmacological receptor mechanisms and effects.

Darryle D. Schoepp has contributed to various peer-reviewed publications. Notable recent papers include:

  • "Cortical influences of serotonin and glutamate on layer V pyramidal neurons", 2021, Progress in Brain Research
  • "Metabotropic glutamate receptors in GtoPdb v.2023.1", 2023, IUPHAR/BPS Guide to Pharmacology CITE
  • "mGlu2/3 receptor agonist (LY354740) in anxiety", 2024, Pharmacology Biochemistry and Behavior
  • "A community-led initiative to de-risk and advance Parkinson's disease therapeutic targets", 2025, npj Parkinson s Disease
  • "Metabotropic glutamate receptors in GtoPdb v.2021.3", 2021, IUPHAR/BPS Guide to Pharmacology CITE

They have frequently published in specialized venues such as IUPHAR/BPS Guide to Pharmacology CITE, Progress in Brain Research, Pharmacology Biochemistry and Behavior, and npj Parkinson's Disease. This specialization reflects a sustained contribution to pharmacology and neuroscience literature.

Collaborations form a significant component of their research output. Among their frequent coauthors are Francine Acher, Giuseppe Battaglia, Hans Bräuner-Osborne, P. Jeffrey Conn, and Robert M. Duvoisin. These collaborations underline an integrated network in the fields of neuropharmacology and receptor biology.

Best Publications

  • Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo

    John R. Cirrito;Kelvin A. Yamada;Mary Beth Finn;Robert S. Sloviter

  • Regulation of neurotransmitter release by metabotropic glutamate receptors.

    Jayne Cartmell;Darryle D. Schoepp

  • Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

    Sandeep T Patil;Lu Zhang;Ferenc Martenyi;Stephen L Lowe

  • Pharmacological agents acting at subtypes of metabotropic glutamate receptors

    Darryle D. Schoepp;David E. Jane;James A. Monn

  • Metabotropic glutamate receptors in brain function and pathology

    Darryle D. Schoepp;P.Jeffrey Conn

  • Unveiling the Functions of Presynaptic Metabotropic Glutamate Receptors in the Central Nervous System

    Darryle D. Schoepp

  • Metabotropic glutamate receptors: From the workbench to the bedside

    F Nicoletti;J Bockaert;Graham L Collingridge;PJ Conn

  • Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

    Chad J. Swanson;Mark Bures;Michael P. Johnson;Anni-Maija Linden

  • Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties.

    James A. Monn;Matthew J. Valli;Steven M. Massey;Rebecca A. Wright

  • Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors

    Darryle Schoepp;Joel Bockaert;Fritz Sladeczek

  • A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission

    Vernon R. J. Clarke;Barbara A. Ballyk;Ken H. Hoo;Allan Mandelzys

  • Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors.

    James A. Monn;Matthew J. Valli;Steven M. Massey;Marvin M. Hansen

  • 3,5‐Dihydroxyphenylglycine Is a Highly Selective Agonist for Phosphoinositide‐Linked Metabotropic Glutamate Receptors in the Rat Hippocampus

    Darryle D. Schoepp;John Goldsworthy;Bryan G. Johnson;Craig R. Salhoff

  • Anxiolytic and Side-Effect Profile of LY354740: A Potent, Highly Selective, Orally Active Agonist for Group II Metabotropic Glutamate Receptors

    David R. Helton;Joseph P. Tizzano;James A. Monn;Darryle D. Schoepp

  • The Metabotropic Glutamate 2/3 Receptor Agonists LY354740 and LY379268 Selectively Attenuate Phencyclidine versus d-Amphetamine Motor Behaviors in Rats

    Jayne Cartmell;James A. Monn;Darryle D. Schoepp

  • Physiological Antagonism between 5-Hydroxytryptamine2A and Group II Metabotropic Glutamate Receptors in Prefrontal Cortex

    Gerard J. Marek;Rebecca A. Wright;Darryle D. Schoepp;James A. Monn

  • LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress.

    Darryle D. Schoepp;Rebecca A. Wright;Louise R. Levine;Brenda Gaydos

  • Evidence for the Role of Metabotropic Glutamate (mGlu)2 Not mGlu3 Receptors in the Preclinical Antipsychotic Pharmacology of the mGlu2/3 Receptor Agonist (–)-(1R,4S,5S,6S)-4-Amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic Acid (LY404039)

    Matthew J. Fell;Kjell A. Svensson;Bryan G. Johnson;Darryle D. Schoepp

  • Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine.

    Michael P. Johnson;Melvyn Baez;G. Erik Jagdmann;Thomas C. Britton

  • Activation of hippocampal metabotropic excitatory amino acid receptors leads to seizures and neuronal damage.

    Aida I. Sacaan;Darryle D. Schoepp

Frequent Co-Authors

Paul L. Ornstein
Paul L. Ornstein Eli Lilly and Company
David Lodge
David Lodge University of Bristol
David L. McKinzie
David L. McKinzie Indiana University
David M. Lodge
David M. Lodge Cornell University
P. Jeffrey Conn
P. Jeffrey Conn Vanderbilt University
Giuseppe Battaglia
Giuseppe Battaglia Sapienza University of Rome
Colleen M. Niswender
Colleen M. Niswender Vanderbilt University
Jeremy D. Coplan
Jeremy D. Coplan SUNY Downstate Medical Center
Leonard A. Rosenblum
Leonard A. Rosenblum SUNY Downstate Medical Center
Sanjay J. Mathew
Sanjay J. Mathew Baylor College of Medicine

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