World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
54
Citations
8300
World Ranking
12830
National Ranking
3395

Overview

Paul L. Ornstein is affiliated with Eli Lilly and Company in the United States. Their research spans multiple fields within medicine and biochemical sciences, with a focus on molecular biology and infectious diseases among other areas.

Ornstein's work extends to several key fields of study including:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these broader fields, their research covers various subfields such as:

  • Molecular Biology
  • Radiology, Nuclear Medicine and Imaging
  • Oncology
  • Infectious Diseases

The scientist's main topics of research include:

  • Historical Medical Research and Treatments
  • Cancer Treatment and Pharmacology
  • Cancer and biochemical research
  • Tuberculosis Research and Epidemiology
  • Cancer therapeutics and mechanisms
  • Biochemical and Molecular Research

Recent publications authored or co-authored by Paul L. Ornstein include:

  • Novel Trifluoromethyl Pyrimidinone Compounds With Activity Against Mycobacterium tuberculosis, 2021, Frontiers in Chemistry
  • Excellence in Medicinal Chemistry: Celebrating ACS Medicinal Chemistry Division (MEDI) Awards. A Call for Nominations, 2023, ACS Medicinal Chemistry Letters
  • Excellence in Medicinal Chemistry: Celebrating ACS Medicinal Chemistry Division (MEDI) Awards. A Call for Nominations, 2023, Journal of Medicinal Chemistry

The primary publication venues for Ornstein's work are:

  • Frontiers in Chemistry
  • ACS Medicinal Chemistry Letters
  • Journal of Medicinal Chemistry

Paul L. Ornstein has frequently collaborated with the following researchers:

  • María-Jesús Blanco
  • A Bryant-Friedrich
  • Gunda I. Georg
  • Amjad Ali
  • Lori Ferrins

Best Publications

  • A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission

    Vernon R. J. Clarke;Barbara A. Ballyk;Ken H. Hoo;Allan Mandelzys

  • Kainate receptors are involved in synaptic plasticity

    Zuner A. Bortolotto;Vernon R. J. Clarke;Caroline M. Delany;Michael C. Parry

  • LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors.

    A.E Kingston;P.L Ornstein;R.A Wright;B.G Johnson

  • A critical role of a facilitatory presynaptic kainate receptor in mossy fiber LTP.

    Sari E Lauri;Zuner A Bortolotto;David Bleakman;Paul L Ornstein

  • A Role for Ca2+ Stores in Kainate Receptor-Dependent Synaptic Facilitation and LTP at Mossy Fiber Synapses in the Hippocampus

    Sari E Lauri;Zuner A Bortolotto;Robert Nistico;David Bleakman

  • Kainate GluR5 receptor subtype mediates the nociceptive response to formalin in the rat.

    Rosa Maria A. Simmons;Dominic L. Li;Ken H. Hoo;Michelle Deverill

  • Synthesis and evaluation of a series of novel 2-[(4-chlorophenoxy)methyl]benzimidazoles as selective neuropeptide Y Y1 receptor antagonists.

    Zarrinmayeh H;Nunes Am;Ornstein Pl;Zimmerman Dm

  • Antagonists of GLU K5 -containing kainate receptors prevent pilocarpine-induced limbic seizures

    Ilse Smolders;Zuner A. Bortolotto;Vernon R. J. Clarke;Ruth Warre

  • The GluR5 subtype of kainate receptor regulates excitatory synaptic transmission in areas CA1 and CA3 of the rat hippocampus

    M Vignes;M Vignes;V.R.J Clarke;M.J Parry;D Bleakman

  • The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity

    Stephen M Fitzjohn;Zuner A Bortolotto;MJ Palmer;Andrew J Doherty

  • NMDA receptor antagonists suppress behaviors but not norepinephrine turnover or locus coeruleus unit activity induced by opiate withdrawal.

    Kurt Rasmussen;Ray W. Fuller;Marsha E. Stockton;Kenneth W. Perry

  • [3H]LY341495 Binding to Group II Metabotropic Glutamate Receptors in Rat Brain

    R A Wright;M B Arnold;W J Wheeler;P L Ornstein

  • Decahydroisoquinolines: novel competitive AMPA/kainate antagonists with neuroprotective effects in global cerebral ischaemia.

    Michael J O'Neill;Ann Bond;Paul L Ornstein;Mark A Ward

  • Pharmacological discrimination of GluR5 and GluR6 kainate receptor subtypes by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahyd roisdoquinoline-3 carboxylic-acid.

    R Bleakman;D D Schoepp;B Ballyk;H Bufton

  • 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability

    Paul L. Ornstein;Thomas J. Bleisch;M. Brian Arnold;Joseph H. Kennedy

  • [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells

    B G Johnson;R A Wright;M B Arnold;W J Wheeler

  • (3SR,4aRS,6RS,8aRS)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid : a structurally novel, systemically active, competitive AMPA receptor antagonist

    Ornstein Pl;Arnold Mb;Augenstein Nk;Lodge D

  • Structure-activity relationship of a series of diaminoalkyl substituted benzimidazole as neuropeptide Y Y1 receptor antagonists.

    Hamideh Zarrinmayeh;Dennis M. Zimmerman;Buddy E. Cantrell;Douglas A. Schober

  • A new method for the efficient conversion of alcohols into iodides via treatment with trimethylsilyl iodide

    Michael E. Jung;Paul L. Ornstein

  • An improved synthesis of homoproline and derivatives

    Robert T. Shuman;Paul L. Ornstein;Jonathan W. Paschal;Paul D. Gesellchen

Frequent Co-Authors

Darryle D. Schoepp
Darryle D. Schoepp Independent Scientist / Consultant, US
David Lodge
David Lodge University of Bristol
David M. Lodge
David M. Lodge Cornell University
Graham L. Collingridge
Graham L. Collingridge Lunenfeld-Tanenbaum Research Institute
Zuner A. Bortolotto
Zuner A. Bortolotto University of Bristol
Smriti Iyengar
Smriti Iyengar Eli Lilly (United States)
Keith A. Wafford
Keith A. Wafford Eli Lilly (United States)
Michael J. O'Neill
Michael J. O'Neill Eli Lilly (United States)
Ilse Smolders
Ilse Smolders Vrije Universiteit Brussel

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