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Chemistry

D-Index
46
Citations
7681
World Ranking
16047
National Ranking
132

Overview

Serge Mignani is affiliated with Universidade da Madeira in Portugal. Their research spans multiple disciplines including biochemistry, genetics and molecular biology, and materials science. Within these domains, their work primarily focuses on molecular biology, polymers and plastics, biomedical engineering, organic chemistry, and biomaterials.

The main topics of investigation in Mignani's research include:

  • Dendrimers and Hyperbranched Polymers
  • RNA Interference and Gene Delivery
  • Advanced biosensing and bioanalysis techniques
  • Nanoplatforms for cancer theranostics
  • Chemical Synthesis and Analysis
  • Nanoparticle-Based Drug Delivery
  • Extracellular vesicles in disease

Several recent publications reflect the scope of their work. Notable papers include:

  • "hERG toxicity assessment: Useful guidelines for drug design" (2020), European Journal of Medicinal Chemistry
  • "Superstructured poly(amidoamine) dendrimer-based nanoconstructs as platforms for cancer nanomedicine: A concise review" (2020), Coordination Chemistry Reviews
  • "Non-invasive intranasal administration route directly to the brain using dendrimer nanoplatforms: An opportunity to develop new CNS drugs" (2020), European Journal of Medicinal Chemistry
  • "Revisiting Cationic Phosphorus Dendrimers as a Nonviral Vector for Optimized Gene Delivery Toward Cancer Therapy Applications" (2020), Biomacromolecules
  • "Dendrimers toward Translational Nanotherapeutics: Concise Key Step Analysis" (2020), Bioconjugate Chemistry

Mignani frequently collaborates with several co-authors, notably Jean-Pierre Majoral, Xiangyang Shi, Mingwu Shen, Mengsi Zhan, and Huxiao Sun. These collaborations have contributed significantly to their research output.

Their publications appear predominantly in scientific journals such as Biomacromolecules, European Journal of Medicinal Chemistry, ACS Nano, Drug Discovery Today, and Nano Today, indicating a consistent presence in venues relevant to both chemistry and nanomedicine.

Best Publications

  • Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy

    Yong Hu;Serge Mignani;Jean-Pierre Majoral;Mingwu Shen

  • Expand classical drug administration ways by emerging routes using dendrimer drug delivery systems: a concise overview.

    Serge Mignani;Saïd El Kazzouli;Mosto Bousmina;Jean-Pierre Majoral

  • Riluzole series. Synthesis and in vivo "antiglutamate" activity of 6-substituted-2-benzothiazolamines and 3-substituted-2-imino-benzothiazolines.

    Jimonet P;Audiau F;Barreau M;Blanchard Jc

  • hERG toxicity assessment: Useful guidelines for drug design.

    Amanda Garrido;Alban Lepailleur;Serge M. Mignani;Patrick Dallemagne

  • Dendrimers in combination with natural products and analogues as anti-cancer agents

    Serge M. Mignani;João C. Rodrigues;João C. Rodrigues;H. Tomás;Maria Zabłocka

  • From PtCl2‐ and Acid‐Catalyzed to Uncatalyzed Cycloisomerization of 2‐Propargyl Anilines: Access to Functionalized Indoles

    Kevin Cariou;Baptiste Ronan;Serge Mignani;Louis Fensterbank

  • Advances in Combination Therapies Based on Nanoparticles for Efficacious Cancer Treatment: An Analytical Report

    Serge Mignani;Maria Bryszewska;Barbara Klajnert-Maculewicz;Maria Zablocka

  • Dendrimer space concept for innovative nanomedicine: A futuristic vision for medicinal chemistry

    Serge Mignani;Saïd El Kazzouli;Mosto Bousmina;Jean-Pierre Majoral

  • Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

    Cédric Lecoutey;Damien Hedou;Thomas Freret;Patrizia Giannoni

  • Poly(amidoamine) Dendrimer-Coordinated Copper(II) Complexes as a Theranostic Nanoplatform for the Radiotherapy-Enhanced Magnetic Resonance Imaging and Chemotherapy of Tumors and Tumor Metastasis

    Yu Fan;Jiulong Zhang;Menghan Shi;Dan Li

  • Doxorubicin-Conjugated PAMAM Dendrimers for pH-Responsive Drug Release and Folic Acid-Targeted Cancer Therapy

    Mengen Zhang;Jingyi Zhu;Yun Zheng;Rui Guo

  • Present drug-likeness filters in medicinal chemistry during the hit and lead optimization process: how far can they be simplified?

    Serge Mignani;Serge Mignani;Serge Mignani;João Rodrigues;João Rodrigues;Helena Tomas;Rachid Jalal

  • Construction of polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors: an innovative theranostic strategy

    Du Li;Yongxing Zhang;Shihui Wen;Yang Song

  • Stereocontrolled cyclopentenone synthesis via cycloaddition

    Barry M. Trost;Peter Seoane;Serge Mignani;Murat Acemoglu

  • Original multivalent copper(II)-conjugated phosphorus dendrimers and corresponding mononuclear copper(II) complexes with antitumoral activities.

    Nabil El Brahmi;Saïd El Kazzouli;Serge M Mignani;El Mokhtar Essassi

  • Dendrimer Space Exploration: An Assessment of Dendrimers/Dendritic Scaffolding as Inhibitors of Protein–Protein Interactions, a Potential New Area of Pharmaceutical Development

    Serge Mignani;Saïd El Kazzouli;Mosto M. Bousmina;Jean-Pierre Majoral

  • Why and how have drug discovery strategies in pharma changed? What are the new mindsets?

    Serge Mignani;Scot Huber;Helena Tomás;João Rodrigues

  • Enhanced Delivery of Therapeutic siRNA into Glioblastoma Cells Using Dendrimer-Entrapped Gold Nanoparticles Conjugated with β-Cyclodextrin

    Jieru Qiu;Lingdan Kong;Xueyan Cao;Aijun Li

  • Why Are the Majority of Active Compounds in the CNS Domain Natural Products? A Critical Analysis

    Unknown

  • Anticancer copper(II) phosphorus dendrimers are potent proapoptotic Bax activators

    Serge Mignani;Nabil El Brahmi;Laure Eloy;Joel Poupon

  • Anticancer siRNA cocktails as a novel tool to treat cancer cells. Part (B). Efficiency of pharmacological action

    Volha Dzmitruk;Aleksandra Szulc;Dzmitry Shcharbin;Anna Janaszewska

Frequent Co-Authors

Anne-Marie Caminade
Anne-Marie Caminade Centre national de la recherche scientifique, CNRS
Xiangyang Shi
Xiangyang Shi Donghua University
Jean-Pierre Majoral
Jean-Pierre Majoral Centre national de la recherche scientifique, CNRS
Maria Bryszewska
Maria Bryszewska University of Łódź
Mingwu Shen
Mingwu Shen Donghua University
Barry M. Trost
Barry M. Trost Stanford University
Janine Cossy
Janine Cossy ESPCI Paris
Pierre Casellas
Pierre Casellas Sanofi (France)
Valentín Ceña
Valentín Ceña University of Castilla-La Mancha
Mosto Bousmina
Mosto Bousmina Université Laval

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