Michael J. O'Neill

Best Publications

• Impaired glymphatic function and clearance of tau in an Alzheimer's disease model.

  Ian F. Harrison;Ozama Ismail;Asif Machhada;Niall Colgan;Niall Colgan

  519
  Citations

• A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

  Zeshan Ahmed;Jane Cooper;Tracey K. Murray;Katya Garn

  515
  Citations

• 6-Hydroxydopamine-induced Apoptosis Is Mediated via Extracellular Auto-oxidation and Caspase 3-dependent Activation of Protein Kinase Cδ

  Katharine Hanrott;Louise Gudmunsen;Michael J. O’Neill;Susan Wonnacott

  326
  Citations

• Fluoxetine-induced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatment.

  G. de Foubert;S.L. Carney;C.S. Robinson;E.J. Destexhe

  302
  Citations

• The role of neuronal nicotinic acetylcholine receptors in acute and chronic neurodegeneration.

  M J O'Neill;T K Murray;V Lakics;N P Visanji

  279
  Citations

• AMPA Receptor Potentiators for the Treatment of CNS Disorders

  Michael J O'Neill;David Bleakman;Dennis M Zimmerman;Eric S Nisenbaum

  277
  Citations

• Conformation Determines the Seeding Potencies of Native and Recombinant Tau Aggregates

  Benjamin Falcon;Annalisa Cavallini;Rachel Angers;Sarah Glover

  274
  Citations

• Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease

  Niall Colgan;Niall Colgan;Bernard Siow;James M. O'Callaghan;Ian F. Harrison

  239
  Citations

• The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments):

  Nathalie Percie du Sert;Alessio Alfieri;Stuard M. Allan;Hilary V. O. Carswell

  202
  Citations

• Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors.

  V Bruno;G Battaglia;A Kingston;M.J O’Neill

  188
  Citations

• Antagonists of GLU K5 -containing kainate receptors prevent pilocarpine-induced limbic seizures

  Ilse Smolders;Zuner A. Bortolotto;Vernon R. J. Clarke;Ruth Warre

  183
  Citations

• LY503430, a Novel α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Potentiator with Functional, Neuroprotective and Neurotrophic Effects in Rodent Models of Parkinson's Disease

  Tracey K. Murray;Katherine Whalley;Christine S. Robinson;Mark A. Ward

  164
  Citations

• An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study

  Marzena Mackowiak;Michael J O’Neill;Caroline A Hicks;David Bleakman

  160
  Citations

• Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau.

  Samuel J. Jackson;Caroline Kerridge;Jane Cooper;Annalisa Cavallini

  159
  Citations

• Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death

  Marcus Keatinge;Hai Bui;Aswin Menke;Yu-Chia Chen

  158
  Citations

• Loss of MicroRNA-7 Regulation Leads to α-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo.

  Kirsty J McMillan;Tracey K Murray;Nora Bengoa-Vergniory;Oscar Cordero-Llana

  156
  Citations

• Decahydroisoquinolines: novel competitive AMPA/kainate antagonists with neuroprotective effects in global cerebral ischaemia.

  Michael J O'Neill;Ann Bond;Paul L Ornstein;Mark A Ward

  149
  Citations

• The adenosine A2A antagonist KF17837 reverses the locomotor suppression and tremulous jaw movements induced by haloperidol in rats: possible relevance to parkinsonism.

  M Correa;A Wisniecki;A Betz;D.R Dobson

  145
  Citations

• Mapping the central effects of ketamine in the rat using pharmacological MRI

  Clare L. Littlewood;Nicholas Jones;Michael J. O’Neill;Stephen N. Mitchell

  141
  Citations

• Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain

  Ksenia Kurbatskaya;Emma Claire Phillips;Cara Louise Croft;Giacomo Dentoni

  141
  Citations

• Evaluation of the mGluR2/3 agonist LY379268 in rodent models of Parkinson's disease.

  Tracey K Murray;Marcus J Messenger;Mark A Ward;Sandra Woodhouse

  134
  Citations