World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
71
Citations
17644
World Ranking
5566
National Ranking
1721

Overview

Keith A. Wafford is affiliated with Eli Lilly in the United States and has contributed extensively to neuroscience research, with a focus on cognitive neuroscience and the regulation of sleep and wakefulness. Their research spans multiple subfields, including cellular and molecular neuroscience, experimental and cognitive psychology, endocrine and autonomic systems, and molecular biology.

The scientist's primary research themes include:

  • Sleep and Wakefulness Research
  • Neuroscience and Neuropharmacology Research
  • Sleep and Related Disorders
  • Neural Dynamics and Brain Function
  • Circadian Rhythm and Melatonin
  • Receptor Mechanisms and Signaling
  • Memory and Neural Mechanisms

Frequent publication venues where their work has appeared include:

  • Neuropsychopharmacology
  • Alzheimer's Research & Therapy
  • Journal of Neuroscience
  • Cerebral Circulation - Cognition and Behavior
  • Journal of Pharmacology and Experimental Therapeutics

Among their recent papers are:

  • The M1/M4 preferring muscarinic agonist xanomeline modulates functional connectivity and NMDAR antagonist-induced changes in the mouse brain (2020, Neuropsychopharmacology)
  • Longitudinal changes in EEG power, sleep cycles and behaviour in a tau model of neurodegeneration (2020, Alzheimer's Research & Therapy)
  • Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice (2022, Journal of Neuroscience)
  • Aberrant waste disposal in neurodegeneration: why improved sleep could be the solution (2021, Cerebral Circulation - Cognition and Behavior)
  • The Dopamine D1 Receptor Positive Allosteric Modulator Mevidalen (LY3154207) Enhances Wakefulness in the Humanized D1 Mouse and in Sleep-Deprived Healthy Male Volunteers (2021, Journal of Pharmacology and Experimental Therapeutics)

Collaborations feature frequently with coauthors such as Gary Gilmour, Andrew McCarthy, Caterina Montani, Carola Canella, and Adam J. Schwarz.

Best Publications

  • Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

    R M McKernan;T W Rosahl;D S Reynolds;C Sur

  • Pharmacological characterization of a novel cell line expressing human α4β3δ GABAA receptors

    N Brown;J Kerby;T P Bonnert;P J Whiting

  • Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors

    Valerie B. Caraiscos;Erin M. Elliott;Kong E. You-Ten;Victor Y. Cheng

  • Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABAA receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster

    Caroline M Priestley;Elizabeth M Williamson;Keith A Wafford;David B Sattelle

  • Molecular and functional diversity of the expanding GABA-A receptor gene family.

    Paul J. Whiting;Timothy P. Bonnert;Ruth M. Mckernan;Sophie Farrar

  • The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid

    Delia Belelli;Jeremy J. Lambert;John A. Peters;Keith Wafford

  • Growth factors regulate the survival and fate of cells derived from human neurospheres

    Maeve A Caldwell;Xiaoling He;Neil Wilkie;Scott Pollack

  • theta, a novel gamma-aminobutyric acid type A receptor subunit.

    T. P. Bonnert;R. M. Mckernan;S. Farrar;B. Le Bourdelles

  • Extrasynaptic GABAA receptors of thalamocortical neurons: a molecular target for hypnotics.

    Delia Belelli;Dianne R. Peden;Thomas W. Rosahl;Keith A. Wafford

  • Sedation and Anesthesia Mediated by Distinct GABAA Receptor Isoforms

    David S. Reynolds;Thomas W. Rosahl;Jennifer Cirone;Gillian F. O'Meara

  • The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit

    Peter B. Wingrove;Keith A. Wafford;Corrina Bain;Paul J. Whiting

  • Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit.

    K A Wafford;S A Thompson;D Thomas;J Sikela

  • Evidence for a Significant Role of α3-Containing GABAA Receptors in Mediating the Anxiolytic Effects of Benzodiazepines

    Rebecca Dias;Wayne F. A. Sheppard;Rosa L. Fradley;Elizabeth M. Garrett

  • Structure and Pharmacology of Vertebrate GABAA Receptor Subtypes

    Paul J. Whiting;Ruth M. McKernan;Keith A. Wafford

  • An Inverse Agonist Selective for α5 Subunit-Containing GABAA Receptors Enhances Cognition

    G. R. Dawson;K. A. Maubach;N. Collinson;M. Cobain

  • α5GABAA Receptors Mediate the Amnestic But Not Sedative-Hypnotic Effects of the General Anesthetic Etomidate

    Victor Y. Cheng;Loren J. Martin;Erin M. Elliott;John H. Kim

  • Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors.

    K L Hadingham;P B Wingrove;K A Wafford;C Bain

  • Neuronally Restricted RNA Splicing Regulates the Expression of a Novel GABAA Receptor Subunit Conferring Atypical Functional Properties

    Paul J. Whiting;George McAllister;Demetrios Vassilatis;Timothy P. Bonnert

  • Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice.

    Cyrille Sur;Keith A. Wafford;David S. Reynolds;Karen L. Hadingham

  • TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.

    John R. Atack;Keith A. Wafford;Spencer J. Tye;Susan M. Cook

Frequent Co-Authors

Paul J. Whiting
Paul J. Whiting University College London
John R. Atack
John R. Atack Cardiff University
Ruth M. McKernan
Ruth M. McKernan MSD (United States)
Gerard R. Dawson
Gerard R. Dawson P1vital LTD
Thomas W. Rosahl
Thomas W. Rosahl MSD (United States)
Jeremy J. Lambert
Jeremy J. Lambert University of Dundee
Delia Belelli
Delia Belelli University of Dundee
Ian Collins
Ian Collins PharmEnable Therapeutics
Angus Murray Macleod
Angus Murray Macleod MSD (United States)
Michael Rowley
Michael Rowley Pharmaron (United Kingdom)

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