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Angus Murray Macleod

Angus Murray Macleod

MSD (United States)
United States

Overview

What is he best known for?

The fields of study he is best known for:

  • Organic chemistry
  • Biochemistry
  • Amino acid

Angus Murray Macleod mainly investigates Stereochemistry, Receptor, Inverse agonist, Pharmacology and GABAA receptor. His Stereochemistry study combines topics in areas such as Antagonist, Partial agonist, Ring and Alkyl. His Receptor research includes elements of Indole test, Combinatorial chemistry and Quinuclidine.

His Inverse agonist research is multidisciplinary, relying on both Convulsant and Chemical synthesis. His study looks at the intersection of Pharmacology and topics like Biological activity with Extravasation, Mechanism of action and Systemic administration. Angus Murray Macleod works mostly in the field of GABAA receptor, limiting it down to concerns involving Morris water navigation task and, occasionally, Electrophysiology and α5IA.

His most cited work include:

  • An Inverse Agonist Selective for α5 Subunit-Containing GABAA Receptors Enhances Cognition (204 citations)
  • Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets. (192 citations)
  • Heterocyclic compounds, processes for their preparation and pharmaceutical compositions containing them (162 citations)

What are the main themes of his work throughout his whole career to date?

Angus Murray Macleod mainly focuses on Stereochemistry, Receptor, Alkyl, Ring and Pharmacology. His Stereochemistry research incorporates elements of Prodrug, Aryl, Chemical synthesis and Trifluoromethyl. Receptor is often connected to Piperidine in his work.

The concepts of his Ring study are interwoven with issues in Group and Medicinal chemistry. The Pharmacology study combines topics in areas such as Selective receptor modulator, Endocrinology and Internal medicine. His Inverse agonist research is multidisciplinary, incorporating perspectives in Alpha, Convulsant, Benzodiazepine and Morris water navigation task.

He most often published in these fields:

  • Stereochemistry (55.23%)
  • Receptor (30.23%)
  • Alkyl (19.19%)

What were the highlights of his more recent work (between 2001-2013)?

  • Receptor (30.23%)
  • Stereochemistry (55.23%)
  • GABAA receptor (11.05%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Receptor, Stereochemistry, GABAA receptor, Inverse agonist and Pharmacology. His Receptor study combines topics from a wide range of disciplines, such as Biological activity and Sleep in non-human animals. His studies deal with areas such as Alpha, Ring, Chemical synthesis and 5-HT2A receptor as well as Stereochemistry.

In his work, Molecule is strongly intertwined with Pyridazine, which is a subfield of GABAA receptor. His biological study spans a wide range of topics, including Convulsant, Benzodiazepine and Morris water navigation task. His Pharmacology research is multidisciplinary, incorporating elements of In vitro, Structure–activity relationship, Disease and Gamma secretase.

Between 2001 and 2013, his most popular works were:

  • An Inverse Agonist Selective for α5 Subunit-Containing GABAA Receptors Enhances Cognition (204 citations)
  • Identification of a Novel, Selective GABAA α5 Receptor Inverse Agonist Which Enhances Cognition (133 citations)
  • An Orally Bioavailable, Functionally Selective Inverse Agonist at the Benzodiazepine Site of GABAA α5 Receptors with Cognition Enhancing Properties (97 citations)

In his most recent research, the most cited papers focused on:

  • Organic chemistry
  • Biochemistry
  • Amino acid

His scientific interests lie mostly in Inverse agonist, Receptor, GABAA receptor, Pharmacology and Chemical synthesis. In the subject of general Receptor, his work in Convulsant is often linked to Anxiogenic, thereby combining diverse domains of study. His Convulsant research includes themes of GABAA-rho receptor and Neuroscience.

His study in Pharmacology is interdisciplinary in nature, drawing from both Pyrazole, Gamma secretase and Disease. Angus Murray Macleod has researched Chemical synthesis in several fields, including Residue, Pyridine, Stereochemistry and Sulfone. In general Stereochemistry study, his work on Piperidine often relates to the realm of Aldehyde oxidase, thereby connecting several areas of interest.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

An Inverse Agonist Selective for α5 Subunit-Containing GABAA Receptors Enhances Cognition

G. R. Dawson;K. A. Maubach;N. Collinson;M. Cobain.
Journal of Pharmacology and Experimental Therapeutics (2006)

283 Citations

Heterocyclic compounds, processes for their preparation and pharmaceutical compositions containing them

Richard Thomas Lewis;Angus Murray Macleod;Kevin John Merchant.
(1993)

245 Citations

Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets.

F.D. Tattersall;W. Rycroft;B. Francis;D. Pearce.
Neuropharmacology (1996)

236 Citations

Novel quinuclidine-based ligands for the muscarinic cholinergic receptor

John Saunders;Mark Cassidy;Stephen B. Freedman;Elizabeth A. Harley.
Journal of Medicinal Chemistry (1990)

223 Citations

Fluorination of 3-(3-(Piperidin-1-yl)propyl)indoles and 3-(3-(Piperazin-1-yl)propyl)indoles Gives Selective Human 5-HT1D Receptor Ligands with Improved Pharmacokinetic Profiles

M. B. Van Niel;I. Collins;M. S. Beer;H. B. Broughton.
Journal of Medicinal Chemistry (1999)

191 Citations

Identification of a Novel, Selective GABAA α5 Receptor Inverse Agonist Which Enhances Cognition

Mark S. Chambers;John R. Atack;Howard B. Broughton;Neil Collinson.
Journal of Medicinal Chemistry (2003)

189 Citations

Novel benzodiazepine receptor partial agonists: oxadiazolylimidazobenzodiazepines.

Frank Watjen;Raymond Baker;Mogens Engelstoff;Richard Herbert.
Journal of Medicinal Chemistry (1989)

188 Citations

Substituted morpholine derivatives and their use as therapeutic agents

Raymond Baker;Timothy Harrison;Angus Murray Macleod;Andrew Pate Owens.
(1994)

182 Citations

Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.

L J Street;R Baker;T Book;C O Kneen.
Journal of Medicinal Chemistry (1990)

181 Citations

An Orally Bioavailable, Functionally Selective Inverse Agonist at the Benzodiazepine Site of GABAA α5 Receptors with Cognition Enhancing Properties

Mark S. Chambers;John R. Atack;Robert W. Carling;Neil Collinson.
Journal of Medicinal Chemistry (2004)

155 Citations

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