MSD (United States)
Angus Murray Macleod mainly investigates Stereochemistry, Receptor, Inverse agonist, Pharmacology and GABAA receptor. His Stereochemistry study combines topics in areas such as Antagonist, Partial agonist, Ring and Alkyl. His Receptor research includes elements of Indole test, Combinatorial chemistry and Quinuclidine.
His Inverse agonist research is multidisciplinary, relying on both Convulsant and Chemical synthesis. His study looks at the intersection of Pharmacology and topics like Biological activity with Extravasation, Mechanism of action and Systemic administration. Angus Murray Macleod works mostly in the field of GABAA receptor, limiting it down to concerns involving Morris water navigation task and, occasionally, Electrophysiology and α5IA.
Angus Murray Macleod mainly focuses on Stereochemistry, Receptor, Alkyl, Ring and Pharmacology. His Stereochemistry research incorporates elements of Prodrug, Aryl, Chemical synthesis and Trifluoromethyl. Receptor is often connected to Piperidine in his work.
The concepts of his Ring study are interwoven with issues in Group and Medicinal chemistry. The Pharmacology study combines topics in areas such as Selective receptor modulator, Endocrinology and Internal medicine. His Inverse agonist research is multidisciplinary, incorporating perspectives in Alpha, Convulsant, Benzodiazepine and Morris water navigation task.
His primary areas of study are Receptor, Stereochemistry, GABAA receptor, Inverse agonist and Pharmacology. His Receptor study combines topics from a wide range of disciplines, such as Biological activity and Sleep in non-human animals. His studies deal with areas such as Alpha, Ring, Chemical synthesis and 5-HT2A receptor as well as Stereochemistry.
In his work, Molecule is strongly intertwined with Pyridazine, which is a subfield of GABAA receptor. His biological study spans a wide range of topics, including Convulsant, Benzodiazepine and Morris water navigation task. His Pharmacology research is multidisciplinary, incorporating elements of In vitro, Structure–activity relationship, Disease and Gamma secretase.
His scientific interests lie mostly in Inverse agonist, Receptor, GABAA receptor, Pharmacology and Chemical synthesis. In the subject of general Receptor, his work in Convulsant is often linked to Anxiogenic, thereby combining diverse domains of study. His Convulsant research includes themes of GABAA-rho receptor and Neuroscience.
His study in Pharmacology is interdisciplinary in nature, drawing from both Pyrazole, Gamma secretase and Disease. Angus Murray Macleod has researched Chemical synthesis in several fields, including Residue, Pyridine, Stereochemistry and Sulfone. In general Stereochemistry study, his work on Piperidine often relates to the realm of Aldehyde oxidase, thereby connecting several areas of interest.
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An Inverse Agonist Selective for α5 Subunit-Containing GABAA Receptors Enhances Cognition
G. R. Dawson;K. A. Maubach;N. Collinson;M. Cobain.
Journal of Pharmacology and Experimental Therapeutics (2006)
Heterocyclic compounds, processes for their preparation and pharmaceutical compositions containing them
Richard Thomas Lewis;Angus Murray Macleod;Kevin John Merchant.
Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets.
F.D. Tattersall;W. Rycroft;B. Francis;D. Pearce.
Novel quinuclidine-based ligands for the muscarinic cholinergic receptor
John Saunders;Mark Cassidy;Stephen B. Freedman;Elizabeth A. Harley.
Journal of Medicinal Chemistry (1990)
Fluorination of 3-(3-(Piperidin-1-yl)propyl)indoles and 3-(3-(Piperazin-1-yl)propyl)indoles Gives Selective Human 5-HT1D Receptor Ligands with Improved Pharmacokinetic Profiles
M. B. Van Niel;I. Collins;M. S. Beer;H. B. Broughton.
Journal of Medicinal Chemistry (1999)
Identification of a Novel, Selective GABAA α5 Receptor Inverse Agonist Which Enhances Cognition
Mark S. Chambers;John R. Atack;Howard B. Broughton;Neil Collinson.
Journal of Medicinal Chemistry (2003)
Novel benzodiazepine receptor partial agonists: oxadiazolylimidazobenzodiazepines.
Frank Watjen;Raymond Baker;Mogens Engelstoff;Richard Herbert.
Journal of Medicinal Chemistry (1989)
Substituted morpholine derivatives and their use as therapeutic agents
Raymond Baker;Timothy Harrison;Angus Murray Macleod;Andrew Pate Owens.
Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.
L J Street;R Baker;T Book;C O Kneen.
Journal of Medicinal Chemistry (1990)
An Orally Bioavailable, Functionally Selective Inverse Agonist at the Benzodiazepine Site of GABAA α5 Receptors with Cognition Enhancing Properties
Mark S. Chambers;John R. Atack;Robert W. Carling;Neil Collinson.
Journal of Medicinal Chemistry (2004)
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