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Angus Murray Macleod

Angus Murray Macleod

D-Index & Metrics

Chemistry

D-Index
42
Citations
5912
World Ranking
17584
National Ranking
4297

Overview

Angus Murray Macleod is affiliated with MSD in the United States and focuses research efforts on chemistry, biochemistry, genetics, molecular biology, and neuroscience. Their work spans several subfields including organic chemistry, molecular biology, cellular and molecular neuroscience, neurology, and physiology, reflecting a multidisciplinary approach to scientific investigation.

Their recent publications cover a range of topics linked to chemical synthesis, pharmacological studies, and neurological disease mechanisms. Notable papers include:

  • Novel Macrocyclic NLRP3 Inhibitors (2024), published in the Journal of Medicinal Chemistry
  • Discovery of ONO-8590580: A novel, potent and selective GABAA α5 negative allosteric modulator for the treatment of cognitive disorders (2020), published in Bioorganic & Medicinal Chemistry Letters
  • PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson's disease models (2025), published in Brain

Frequent coauthors in their collaborative work include Kim L. Matthews, Reena Halai, Matthew A. Cooper, Stefanie Mesch, and Jonathan Shannon. Their partnerships reflect repeated collaborative efforts in related research areas.

Common publication venues for their work are:

  • Journal of Medicinal Chemistry
  • Bioorganic & Medicinal Chemistry Letters
  • Brain

The main topics present in Macleod's scientific investigations involve:

  • Synthesis of heterocyclic compounds
  • Synthesis and biological activity
  • Chemical synthesis and pharmacological studies
  • Pharmacological receptor mechanisms and effects
  • Neuroscience and neuropharmacology research
  • Nicotinic acetylcholine receptors study
  • Parkinson's disease mechanisms and treatments

Best Publications

  • An Inverse Agonist Selective for α5 Subunit-Containing GABAA Receptors Enhances Cognition

    G. R. Dawson;K. A. Maubach;N. Collinson;M. Cobain

  • Heterocyclic compounds, processes for their preparation and pharmaceutical compositions containing them

    Richard Thomas Lewis;Angus Murray Macleod;Kevin John Merchant

  • Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets.

    F.D. Tattersall;W. Rycroft;B. Francis;D. Pearce

  • Novel quinuclidine-based ligands for the muscarinic cholinergic receptor

    John Saunders;Mark Cassidy;Stephen B. Freedman;Elizabeth A. Harley

  • Fluorination of 3-(3-(Piperidin-1-yl)propyl)indoles and 3-(3-(Piperazin-1-yl)propyl)indoles Gives Selective Human 5-HT1D Receptor Ligands with Improved Pharmacokinetic Profiles

    M. B. Van Niel;I. Collins;M. S. Beer;H. B. Broughton

  • Identification of a Novel, Selective GABAA α5 Receptor Inverse Agonist Which Enhances Cognition

    Mark S. Chambers;John R. Atack;Howard B. Broughton;Neil Collinson

  • Novel benzodiazepine receptor partial agonists: oxadiazolylimidazobenzodiazepines.

    Frank Watjen;Raymond Baker;Mogens Engelstoff;Richard Herbert

  • Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.

    L J Street;R Baker;T Book;C O Kneen

  • Substituted morpholine derivatives and their use as therapeutic agents

    Raymond Baker;Timothy Harrison;Angus Murray Macleod;Andrew Pate Owens

  • An Orally Bioavailable, Functionally Selective Inverse Agonist at the Benzodiazepine Site of GABAA α5 Receptors with Cognition Enhancing Properties

    Mark S. Chambers;John R. Atack;Robert W. Carling;Neil Collinson

  • Selective, Orally Active γ-Aminobutyric AcidA α5 Receptor Inverse Agonists as Cognition Enhancers

    Francine Sternfeld;Robert W. Carling;Richard A. Jelley;Tamara Ladduwahetty

  • 3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists.

    M Rowley;D J Hallett;S Goodacre;C Moyes

  • A Novel, Broad-Spectrum Inhibitor of Enterovirus Replication That Targets Host Cell Factor Phosphatidylinositol 4-Kinase IIIβ

    Hilde M van der Schaar;Pieter Leyssen;Hendrik Jan Thibaut;Armando De Palma

  • Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor.

    M A Cascieri;A M Macleod;D Underwood;L L Shiao

  • Oxadiazoles useful in the treatment of senile dementia

    Raymond Baker;Angus Murray Macleod;Kevin John Merchant;John Saunders

  • Thiadiazoles useful in the treatment of senile dementia

    Raymond Baker;John Saunders;Angus M. Macleod;Kevin Merchant

  • N-Acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists

    Angus M. MacLeod;Kevin J. Merchant;Margaret A. Cascieri;Sharon Sadowski

  • 4-(Phenylsulfonyl)piperidines: Novel, Selective, and Bioavailable 5-HT2A Receptor Antagonists

    Stephen R. Fletcher;Frank Burkamp;Peter Blurton;Susan K. F. Cheng

  • HETEROCYCLIC COMPOUNDS, COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY

    Macleod Angus M

  • Synthesis and Biological Evaluation of 3-Heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and Analogues as Subtype-Selective Inverse Agonists for the GABAAα5 Benzodiazepine Binding Site

    Leslie J. Street;Francine Sternfeld;Richard A. Jelley;Austin J. Reeve

  • Heterocyclic amide derivatives as tachykinin antagonists

    Richard J. Lewis;Angus M. MaCleod;Kevin J. Merchant

Frequent Co-Authors

Raymond Baker
Raymond Baker MSD (United States)
Margaret A. Cascieri
Margaret A. Cascieri MSD (United States)
John R. Atack
John R. Atack Cardiff University
Gerard R. Dawson
Gerard R. Dawson P1vital LTD
Keith A. Wafford
Keith A. Wafford Eli Lilly (United States)
Ruth M. McKernan
Ruth M. McKernan MSD (United States)
Michael Rowley
Michael Rowley Pharmaron (United Kingdom)
Richard G. Ball
Richard G. Ball MSD (United States)
Richard Hargreaves
Richard Hargreaves Harvard Medical School
Peter W. Hunt
Peter W. Hunt University of California, San Francisco

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