World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
105
Citations
41739
World Ranking
445
National Ranking
252

Research.com Recognitions

  • 2020 - Member of the National Academy of Sciences
  • 2008 - Fellow of the American Academy of Arts and Sciences

Overview

Lawrence S.B. Goldstein is affiliated with the University of California, San Diego in the United States. Their research spans several fields including Medicine and Biochemistry, Genetics and Molecular Biology, with specific subfields covering Physiology, Molecular Biology, Cellular and Molecular Neuroscience, Cell Biology, and Oncology.

Their work focuses on a range of topics including Alzheimer's disease research and treatments, pluripotent stem cells, biomedical ethics and regulation, CRISPR and genetic engineering, neuroscience and neural engineering, cellular transport and secretion, and biomedical and engineering education.

Recent significant publications authored or co-authored by Goldstein include:

  • "Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients," 2021, Cell Stem Cell
  • "Brain organoids, consciousness, ethics and moral status," 2022, Seminars in Cell and Developmental Biology
  • "Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization," 2020, Molecular Biology of the Cell
  • "Amyloidogenic Processing of Amyloid Precursor Protein Drives Stretch-Induced Disruption of Axonal Transport in hiPSC-Derived Neurons," 2021, Journal of Neuroscience
  • "Evidence generation and reproducibility in cell and gene therapy research: A call to action," 2021, Molecular Therapy - Methods & Clinical Development

Goldstein frequently publishes in venues such as Value in Health, Cell Stem Cell, Alzheimer's & Dementia, Cureus, and Seminars in Cell and Developmental Biology.

Collaborators often appearing alongside Goldstein include Douglas Galasko, Rik van der Kant, A Desai, Shauna H. Yuan, and Vanessa F. Langness.

Over the course of their career, Goldstein has been recognized by election to prestigious bodies, including becoming a Fellow of the American Academy of Arts and Sciences in 2008 and a Member of the National Academy of Sciences in 2020.

Best Publications

  • Comparative Genomics of the Eukaryotes

    Gerald M. Rubin;Mark D. Yandell;Jennifer R. Wortman;George L. Gabor

  • Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease.

    Gorazd B. Stokin;Concepción Lillo;Tomás L. Falzone;Richard G. Brusch

  • Somatic coding mutations in human induced pluripotent stem cells

    Athurva Gore;Zhe Li;Ho Lim Fung;Jessica E. Young

  • Bead movement by single kinesin molecules studied with optical tweezers

    Steven M. Block;Lawrence S. B. Goldstein;Bruce J. Schnapp

  • Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice.

    A. M. Clement;M. D. Nguyen;E. A. Roberts;E. A. Roberts;M. L. Garcia;M. L. Garcia

  • Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

    Mason A. Israel;Shauna H. Yuan;Cedric Bardy;Sol M. Reyna

  • A standardized kinesin nomenclature.

    Carolyn J. Lawrence;R. Kelly Dawe;Karen R. Christie;Don W. Cleveland

  • The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation

    Ian Lian;Joungmok Kim;Hideki Okazawa;Jiagang Zhao

  • Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease

    Fangming Lin;Thomas Hiesberger;Kimberly Cordes;Angus M. Sinclair

  • Microtubule-based transport systems in neurons: the roles of kinesins and dyneins.

    Lawrence S. B. Goldstein;Zhaohuai Yang

  • Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I.

    Adeela Kamal;Gorazd B Stokin;Zhaohaui Yang;Chun-Hong Xia

  • Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

    Shermali Gunawardena;Lu-Shiun Her;Richard G. Brusch;Robert A. Laymon

  • Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP.

    Adeela Kamal;Angels Almenar-Queralt;James F. LeBlanc;Elizabeth A. Roberts

  • Characterization and use of the Drosophila metallothionein promoter in cultured Drosophila melanogaster cells.

    Thomas A. Bunch;Yevgenya Grinblat;Lawrence S.B. Goldstein

  • Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

    Ahmad Salehi;Jean Dominique Delcroix;Pavel V. Belichenko;Ke Zhan

  • Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II

    Joseph R. Marszalek;Pilar Ruiz-Lozano;Elizabeth Roberts;Kenneth R. Chien

  • CENP-E Is a Plus End–Directed Kinetochore Motor Required for Metaphase Chromosome Alignment

    Kenneth W Wood;Roman Sakowicz;Lawrence S.B Goldstein;Don W Cleveland

  • Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.

    Shermali Gunawardena;Lawrence S.B. Goldstein

  • A three-domain structure of kinesin heavy chain revealed by DNA sequence and microtubule binding analyses

    Joy T. Yang;Robert A. Laymon;Lawrence S.B. Goldstein

  • Genetic evidence for selective transport of opsin and arrestin by kinesin-II in mammalian photoreceptors.

    Joseph R Marszalek;Xinran Liu;Elizabeth A Roberts;Daniel Chui

Frequent Co-Authors

David S. Williams
David S. Williams University of California, Los Angeles
Don W. Cleveland
Don W. Cleveland University of California, San Diego
Stephen Safe
Stephen Safe Texas A&M University
Ronald D. Vale
Ronald D. Vale University of California, San Francisco
Daniel Branton
Daniel Branton Harvard University
Kelly A. Frazer
Kelly A. Frazer University of California, San Diego
Mark D. Minden
Mark D. Minden Princess Margaret Cancer Centre
Fred H. Gage
Fred H. Gage Salk Institute for Biological Studies
James E. Womack
James E. Womack Texas A&M University
Marco A. Marra
Marco A. Marra University of British Columbia

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Molecular biology is a versatile field that often overlaps with many allied health and research careers. If you’re considering further education beyond molecular biology, a popular choice is entering accredited speech pathology programs. These programs can lead to rewarding roles in healthcare and serve as a complimentary next step for molecular biology graduates.

For those without a bachelor’s in communication sciences, speech language pathology bridge programs online offer a pathway to become a speech-language pathologist. Similarly, careers in nursing are in high demand, and accelerated nursing programs for non nurses allow those with unrelated degrees to fast-track entry into nursing.

Many students also explore mental health professions. The growth in demand for advanced practice nurses is reflected in competitive psychiatric nurse practitioner salary rates. Exploring these connected career pathways can open diverse opportunities for those with a strong background in molecular biology.

Best Scientists Citing Lawrence S.B. Goldstein

Trending Scientists

Recently Published Articles